A5052333079- Angiogenesis and VEGF in Cancer
- Photoreceptor and optogenetics research
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Hearing Loss and Rehabilitation
- Craniofacial Disorders and Treatments
- Retinal Development and Disorders
- Meningioma and schwannoma management
- Neuroscience and Neuropharmacology Research
- Corneal Surgery and Treatments
- Wound Healing and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Cerebral Venous Sinus Thrombosis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Proteoglycans and glycosaminoglycans research
- Periodontal Regeneration and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Noise Effects and Management
- Cell Adhesion Molecules Research
- Sinusitis and nasal conditions
- Surgical Sutures and Adhesives
- Aquatic Invertebrate Ecology and Behavior
- Oral and Maxillofacial Pathology
- Physiological and biochemical adaptations
Rush University Medical Center
2023-2025
Rush University
2025
Harvard University
2024
Temple University
2024
American Academy of Otolaryngology — Head and Neck Surgery
2024
Twin Cities Orthopedics
1994-1997
University of Minnesota
1970-1997
Macalester College
1972-1995
University of Minnesota Medical Center
1969
Abstract The object of this study was to examine the initiation and pattern capillary growth associated with wound healing. Collagen sponges were implanted subcutaneously in hind limbs adult male rats stimulate formation granulation tissue. Blood vessels euthanized perfused Mercox (an acrylic monomer) via abdominal aorta at selected periods time following sponge implantation. When perfusate completely cured, parajacent tissues excised subsequently macerated by alternating immersion 40% KOH...
Abstract Objective Medical literature identifies stark racial disparities in head and neck cancer (HNC) the United States, primarily between non‐Hispanic white (NHW) black (NHB) populations. The etiology of this disparity is often attributed to inequitable access health care socioeconomic status (SES). However, other contributors have been reported. We performed a systematic review better understand multifactorial landscape driving HNC. Data Sources A was conducted Covidence following...
Background: Pulsatile tinnitus (PT) is a form of described as rhythmic beating or whooshingin the ear ears. Causes PT can be quite variable and difficult to assess.<br /> Purpose: Ambient pressure tympanography (APT) aid in diagnosing pathology temporalbone that may cause PT. APT measures compliance tympanic membrane (TM) over span of15–60 s with ambient canal. The reflex decay test protocol includes measurechanges admittance tonal stimulus. Using contralateral setup withoutthe use...
Unilateral sphenoid sinus opacification on computed tomography is caused by a variety of pathologies including inflammatory and infectious sinusitis, benign malignant tumors, encephaloceles. The purpose this study was to report craniofacial pain locations outcomes in unilateral sinusitis (USS) patients who underwent endoscopic surgery (ESS).
Background: Surgical treatment of skull base pathologies is frequently discussed in the context endoscopic endonasal or transcranial approaches. Combined and open approaches have been utilized staged sequential fashion, with goal reducing risk postoperative cerebrospinal fluid leak, morbidity, wound infection/complication, failure to achieve adequate reconstruction. However, few studies described concurrent use safely address complex pathologies. Methods: We treated 13 patients primary...
Abstract Objective This study investigated whether patients’ perception of their hearing loss accurately reflects measured thresholds on audiogram, specifically relating to a mild moderate loss, which is the determining candidacy for over‐the‐counter (OTC) aids. Study Design Retrospective review. Setting Audiology clinic at tertiary care center. Methods retrospective chart review included 232 ears from 116 patients older than 18 years seen audiograms our audiology between 2022 and 2023. Data...
Abstract Introduction Hypoglossal nerve stimulation (HGNS) is an effective treatment for obstructive sleep apnea (OSA) in patients intolerant to continuous positive airway pressure (CPAP). Limited data exists on HGNS outcomes with REM-exacerbated OSA (REM-OSA), defined by a REM-to-NREM apnea-hypopnea index (AHI) &gt;2. This study investigates postoperative REM-OSA treated HGNS. Methods single-institution retrospective evaluated who underwent placement from 2016-2023. Inclusion criteria...
Background Chronic rhinosinusitis (CRS) can be difficult to treat medically secondary crusting and biofilms resistant oral antibiotics. Treatment with topical antibiotics has grown in popularity due their ability administer a high local drug concentration while mitigating systemic effects. Published literature on antibiotic efficacy for CRS is mixed sparse. Objective To describe the of postoperative mupirocin rinses reducing objective subjective markers disease severity. Methods Patients...
Abstract Introduction Drug-Induced Sleep Endoscopy with Positive Airway Pressure (DISE-PAP) provides a quantitative evaluation of upper airway collapsibility, known as the pharyngeal opening pressure (PhOP). Limited research has examined relationship between PhOP and required level CPAP. This study aimed to investigate CPAP PhOP. Methods single-institution retrospective evaluated patients who underwent DISE-PAP in supine position from 2022-2024. Adults ≥18 years age OSA (AHI ≥ 5), &gt;2...
Angiogenesis induced by transforming growth factor beta (TGFB) implanted in the rabbit cornea is accompanied an influx of inflammatory cells. To determine if cells are mediators neovascularization, they were depleted local administration methylprednisolone acetate (MPA). Subconjunctival injections 16 mg MPA immediately following implantation 50 ng TGFB prevented inflammation and subsequent formation capillaries. If delayed 48 hr allowed to enter cornea, angiogenesis occurred, demonstrating...
The ultrastructure of the lateral plexus in compound eye Limulus is investigated by serial section technique. "Cores" tissue containing axons, plexus, and neuropile associated with one sensory ommatidium show following features: (a) collateral branches from retinular cells do not contribute to proper, but form contacting collaterals a self-contained cluster axons; (b) eccentric cell axons always branch repeatedly upon leaving parent axon, compose bulk plexus; (c) most distal an axon appear...
The archetypical gill structure of lamellibranch bivalves has been the focus research concerning feeding mechanisms these clams. In recent years there debate over whether acts as a sieve or ciliature produces hydromechanical shear forces for capture particles during feeding. corbiculacean bivalves, shows considerable interspecific variability in integrity ciliary tracts. A novel structure, frontal cirrus that varies organization, distribution, and abundance three species studied, found....
The increasing incidence of head and neck squamous cell carcinoma (HNSCC) is associated with the rising prevalence human papillomavirus (HPV)-associated disease.1 HPV-associated HNSCC represents a distinct clinical entity favorable prognosis compared to non-HPV-associated HNSCC.1 Current guidelines recommend imaging within 6 months after treatment office-based physical exams from that point at specified intervals. However, surveillance in this population can be demanding as providers balance...
The cytokine macrophage colony‐stimulating factor was implanted in the rabbit cornea over a wide dose range (1 ng to 100 µg) assay its angiogenic activity vivo. Neovascularization occurred dose‐dependent manner, and maximum angiogenesis only with µg. Histologic analysis revealed that corneas were free of inflammation at lower doses, but had slight 50 Nonspecific esterase staining frozen sections transmission electron microscopy inflammatory cells predominantly macrophages, very few...
Background: Surgical treatment of complex skull base pathologies often involves endoscopic endonasal or transcranial approaches, with combined approaches used in a staged sequential manner. Few studies have explored the concurrent use these methods.
Abstract Introduction Drug-induced sleep endoscopy (DISE) is the most commonly utilized diagnostic tool for determining sites of upper airway collapse in patients with obstructive apnea (OSA) seeking alternative treatments to continuous positive pressure (CPAP). (DISE-PAP) a new technique that allows both qualitative visualization as well quantitative measure collapsibility. In this study, we sought determine if anatomic features neck circumference and body mass index (BMI) impact degree...
Abstract The structure of the “Corneagen,” i.e., epidermis lying beneath cornea‐lens lateral eyes adult intermolt Limulus polyphemus was studied with light and electron microscopy. This layer is composed heavily columnar cells containing a striking number cytoplasmic microtubules. Many microtubules are grouped into compact bundles or fascicles, generally each cell having at least one microtubule bundle. cornealens end has numerous microvilli, core delicate filaments. crypts between...
The objective of this study was to determine the angiogenic potential transforming growth factor-alpha (TGF-a). Recombinant human TGF-a (0.25 5.0 ug) implanted in rabbit cornea. eyes were monitored daily for corneal opacification, dilation limbal blood vessels, and new capillaries toward TGF-a. Two, 3 7 days post-implantation, harvested histology, transmission electron microscopy, or examination vascular corrosion casts with scanning microscopy. (2.5-5.0 consistently elicited an influx...