A5101850400- Nutrition and Health in Aging
- Mycobacterium research and diagnosis
- Cardiovascular Function and Risk Factors
- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Toxin Mechanisms and Immunotoxins
- Hip and Femur Fractures
- Diabetic Foot Ulcer Assessment and Management
- Spinal Cord Injury Research
- Endoplasmic Reticulum Stress and Disease
- Intraperitoneal and Appendiceal Malignancies
- Cerebrovascular and Carotid Artery Diseases
- Atherosclerosis and Cardiovascular Diseases
- Genetic Associations and Epidemiology
- Wound Healing and Treatments
- Digestive system and related health
- Cardiovascular Disease and Adiposity
- Inflammatory Biomarkers in Disease Prognosis
- Intensive Care Unit Cognitive Disorders
- Potassium and Related Disorders
- Tuberculosis Research and Epidemiology
Huazhong University of Science and Technology
2021-2025
Tongji Hospital
2022-2025
First Affiliated Hospital of Hebei Medical University
2022
Hebei North University
2022
Central Hospital of Wuhan
2022
Medtronic (United States)
2021
Union Hospital
2021
Mansfield University
2021
Daiichi Sankyo (United States)
2021
Anhui Provincial Hospital
2020
Identifying sarcopenia's causally associated plasma proteins would provide potential therapeutic targets.We screened out sarcopenia-related with genome-wide association studies (GWAS) summary data and cis-protein loci genetic instruments. Summary of sarcopenia were obtained from a GWAS 256,523 Europeans aged 60 years over. The causal effects the investigated by cis-Mendelian Randomisation (MR) multiverse sensitivity analysis. We also explored robust proteins' associations appendicular lean...
This study aimed to investigate the relationship between visceral obesity and various disease traits, as well identify potential safe targets for prevention treatment of obesity. Univariable multivariable Mendelian randomization (MR) analyses were performed examine associations 1883 traits. Furthermore, we assessed effect 1684 protein expressions on using available quantitative trait locus data plasma proteins. To evaluate safety profiles associated with biomarker intervention, conducted...
Emergency laparotomy (EL) has a high mortality rate. Clinically, frail patients have poor tolerance for EL. In recent years, sarcopenia been used as an important indicator of frailty and received much attention. There five different calculation methods psoas computed tomography (CT) to measure sarcopenia, but lack assessment these in Eastern Asian EL patients.We conducted 2-year retrospective cohort study over 18 years age who underwent our institution. Five CT measurement values (PMI:...
Opioid-induced respiratory depression is common on the general care floor. However, clinical and economic burden of not well-described. The PRediction Depression In patients monitored by capnoGraphY (PRODIGY) trial created a prediction tool to identify at risk depression. purpose this retrospective sub-analysis was examine healthcare utilization hospital cost associated with depression.One thousand three hundred thirty-five (N = 769 United States patients) enrolled in PRODIGY received...
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a serious contagious disease. MTB-encoded small regulatory RNA (sRNA) MTS2823 was reported to be upregulated in the plasma of TB patients. Nevertheless, whether implicated MTB drug resistance unclear. Human macrophage cell line THP-1 infected with drug-susceptible strain H37Rv or multidrug-resistant (MDR) 8462. Colony-forming unit assay implemented for evaluating intracellular growth strains. Enzyme-linked...
Abstract Background Coronary distensibility index (CDI), as an early predictor of cardiovascular diseases, has the potential to complement coronary computed tomography angiography (cCTA)-derived fractional flow reserve (CT-FFR) for predicting major adverse cardiac events (MACEs). Thus, prognostic value CT-FFR combined with CDI MACEs is worth exploring. Methods Patients a moderate or severe single left anterior descending artery stenosis were included and underwent FFR analysis based on cCTA,...
Abstract Funding Acknowledgements Type of funding sources: Private company. Main source(s): Daiichi Sankyo Background and Purpose The large global Edoxaban Treatment in routiNe clinical prActice (ETNA)-AF program was designed to assess the safety effectiveness edoxaban, complementing randomized trials. Methods ETNA collects data on patient characteristics events unselected AF patients treated with edoxaban for stroke prevention, integrating from prospective, noninterventional studies...
Objective To determine the prevalence of microembolic signals(MES) by using transcranial Doppler(TCD) and to assess their association with neuropsychiatric systemic lupus erythematosus(NPSLE) clinical presentations in patients erythematosus(SLE). Methods Forty-four SLE underwent TCD for 30 min were included MES detection information recorded. In addition frequency MES, followed-up six-month. Mann-Whitney U test Fisher exact applied investigate characteristics. Results There 4...
Abstract Background With better patient selection and the increasing experience in patients undergoing hyperthermic intraperitoneal chemotherapy (HIPEC) combined surgery, rate of severe postoperative complications mortality decreased significantly. However, leukopenia neutropenia were still a particular concern, their relation to sarcopenia was not clarified. Methods Data consecutive who underwent HIPEC for gastrointestinal cancer collected analyzed retrospectively between September 2020...
Purpose:Helicobacter species associated with human infection include Helicobacter pylori, heilmannii and others. The prevalence of is found between 1-6% which much less common than pylori. Scant amount information was available about its treatment strategy. We reported one patient dyspepsia secondary to who successfully treated standard triple therapy. Methods: This a retrospective chart review. patient's clinical visit, endoscopy pathology report were reviewed. Clinical Case: A 43-year-old...
Objective To investigate the efficacy and nursing experience of vacuum sealing drainage (VSD) combined with topical oxygen therapy on healing pressure ulcers in intensive care unit. Methods Totally 44 cases patients unit stage Ⅲ Ⅳ bedsore, from May 2015 to October 2017, were divided into 2 groups according random number table.22 cases, as control group, treated routine methods VSD.22 test basis treatment 10 days for a cycle. The effects two compared wound rate, bacterial quantitative,...
Abstract Funding Acknowledgements Type of funding sources: Private company. Main source(s): Daiichi Sankyo Background Age is a risk factor for ischemic stroke and bleeding in patients with atrial fibrillation (AF). The large dataset from the global prospective, noninterventional ETNA-AF program allows analysis impact age on clinical events AF treated edoxaban. Purpose Evaluate safety effectiveness edoxaban by subgroups events. Methods Baseline patient characteristics, thromboembolic events,...
Abstract Aims Little is known about the relative importance of body volume and haemodynamic parameters in development worsening renal function acutely decompensated heart failure (ADHF). To study relationship between parameters, water content patients with reduced ejection fraction (HFrEF) hospitalised for ADHF. Methods results This prospective observational involved 51 consecutive HFrEF (age: 73±14 years, male: 60%, left ventricular fraction: 33.3%±9.9%) Echocardiographic-determined...