A5041195462- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Lipid metabolism and biosynthesis
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Tracheal and airway disorders
- Cardiovascular Function and Risk Factors
- Atomic and Subatomic Physics Research
- Pharmacology and Obesity Treatment
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Tumors and Oncological Cases
- Cholesterol and Lipid Metabolism
- Soft tissue tumor case studies
- Sleep and Wakefulness Research
- Mindfulness and Compassion Interventions
- Genetic Syndromes and Imprinting
- Endoplasmic Reticulum Stress and Disease
- Photochromic and Fluorescence Chemistry
- Congenital Diaphragmatic Hernia Studies
- Digestive system and related health
- Connective tissue disorders research
- Advanced Optical Sensing Technologies
The Ohio State University
2019-2025
Lung Institute
2025
Southwestern Medical Center
2023-2024
The University of Texas Southwestern Medical Center
2020-2024
Monash Children’s Hospital
2021-2024
Murdoch Children's Research Institute
2024
The Ohio State University Wexner Medical Center
2023-2024
National University Health System
2016-2017
University of Wolverhampton
2015
National University Hospital
2014
The role of probiotics in regulating intestinal flora to enhance host immunity has recently received widespread attention. Altering the human gut microbiota may increase predisposition several disease phenotypes such as inflammation and metabolic disorders. converts dietary nutrients into metabolites that serve biologically active molecules modulating regulatory functions host. Probiotics, which are microorganisms, play a versatile restoring composition microbiota, helping improve prevent...
Abstract Purpose of Review Although the molecular mechanism insulin resistance involves multiple factors and several intrinsic extrinsic mechanisms have been identified, this comprehensive review provides key information on some core complex interactions molecules involved in signaling pathways resistance. Recent Findings Diabetes Mellitus, most common metabolic disorder, is one greatest global medical challenges at present. There has a significant increase complications associated with...
The lipocalin proteins are a large family of small extracellular that demonstrate significant heterogeneity in sequence similarity and have highly conserved crystal structures. They variety functions, including acting as carrier proteins, transporting retinol, participating olfaction, synthesizing prostaglandins. Importantly, they also play critical role human diseases, cancer. Additionally, involved regulating cellular homeostasis immune response dispensing various compounds. This...
Abstract Obesity, a rapidly expanding epidemic worldwide, is known to exacerbate many medical conditions, making it significant factor in multiple diseases and their associated complications. This threatening linked various harmful conditions such as type 2 diabetes mellitus, hypertension, metabolic dysfunction‐associated steatotic liver disease, polycystic ovary syndrome, cardiovascular (CVDs), dyslipidemia, cancer. The rise urbanization sedentary lifestyles creates an environment that...
Tumour metastasis to the brain is a common and deadly development in certain cancers; 18–30 % of breast tumours metastasise brain. The contribution that gene silencing through epigenetic mechanisms plays these metastatic not well understood. We have carried out bioinformatic screen genome-wide tumour methylation data available at Cancer Genome Atlas (TCGA) broad literature review identify candidate genes may contribute (BBM). This analysis identified 82 candidates. investigated status using...
Genetic variants that increase the risk of fatty liver disease and cirrhosis have recently been identified in proximity membrane-bound O-acyltransferase domain-containing 7 (MBOAT7). To elucidate link between these disease, we characterized Mboat7 liver-specific KO mice (Mboat7 LSKO). Chow-fed LSKO developed livers associated injury. Lipidomic analysis using MS revealed a pronounced reduction 20-carbon PUFA content phosphatidylinositols (PIs) but not other phospholipids. The change acid...
Abstract Lipid droplets are organelles with unique spherical structures. They consist of a hydrophobic neutral lipid core that varies depending on the cell type and tissue. These surrounded by phospholipid monolayers, along heterogeneous proteins responsible for synthesis metabolism. Additionally, there specialized droplet‐associated surface proteins. Recent evidence suggests from perilipin family (PLIN) associated involved in their formation. have specific roles hepatic droplet metabolism,...
Abstract Increasing evidence suggests cardiac function improves in healthy and failing hearts alongside circulating ketones (1–4 mM). This study characterized blood flow responses to a ketogenic beverage compared volume/calorie matched placebo with repeated imaging over 120 min. was two‐group, placebo‐controlled, acute study. Adults without abnormalities underwent baseline MRI including quantitative myocardial perfusion measure (MBF). Subjects consumed 50 g of ketogenic‐promoting...
Colorectal cancer (CRC) is a highly prevalent and lethal worldwide. Approximately 45% of CRC patients harbor gain-in-function mutation in KRAS. KRAS the most frequently mutated oncogene accounting for approximately 25% all human cancers. Gene mutations cause constitutive activation protein MAPK/AKT signaling, resulting unregulated proliferation survival cells other aspects malignant transformation, progression, metastasis. While has long been considered undruggable, FDA recently approved two...
Irritable bowel syndrome (IBS) is a common functional disorder of the gut-brain axis, characterized by abdominal pain and altered habits. A 38-year-old male patient with sedentary lifestyle, diagnosed IBS based on Rome 4 criteria, was underwent Yoga Naturopathy (Y&N) interventions for one month in our outpatient department. The result showed reduced Bowel Syndrome Severity Score (IBS-SSS) (315 to 109) perceived stress (PSS) score (29 12) level. Heart rate variability (HRV) analysis increased...
Abstract Purpose To present and assess an outlier mitigation method that makes free‐running volumetric cardiovascular MRI (CMR) more robust to motion. Methods The proposed method, called compressive recovery with rejection (CORe), models outliers in the measured data as additive auxiliary variable. We enforce MR physics‐guided group sparsity on variable, jointly estimate it along image using iterative algorithm. For evaluation, CORe is first compared traditional compressed sensing (CS),...
Non-alcoholic fatty liver disease (NAFLD) is a common and prevalent disorder affecting 25 percent of the adults in United States 32 globally. It one causes chronic characterized by steatosis, which can lead to inflammation, fibrosis, cirrhosis. NAFLD strongly associated with obesity insulin resistance. Multiple genetic variants have been consistently found be NAFLD; them TMC4-MBOAT7 loci. One variant (rs641738 C>T) within MBOAT7 encoding lysophosphatidyl inositol acyltransferase increases...
Background: Accelerated real-time cine (RT-Cine) imaging enables cardiac function assessment without the need for breath-holding. However, when performed during in-magnet exercise, RT-Cine images may exhibit significant motion artifacts. Methods: By projecting time-averaged to subspace spanned by coil sensitivity maps, we propose a reweighting (CR) method automatically suppress subset of receive coils that introduces high level artifacts in reconstructed image. data collected at rest and...
Free-breathing self-gated CMR 4D flow imaging using traditional Compressed Sensing (CS) methods invariably contains motion artifacts due to the inaccuracy of self-gating signal. Self-gating signal degrades even further in case exercise stress excessive movement subject. We propose Compressive recovery with Outlier Rejection (CORe) reduce artifacts. Using data from a 2D digital phantom and under rest conditions, we demonstrate that CORe is effective suppressing while maintaining agreement...
A comprehensive exercise stress cardiovascular MRI (Ex-CMR) was performed in twelve healthy subjects. Biventricular quantification from real-time cine, while hemodynamic parameters the ascending aorta and main pulmonary artery were estimated using flow. The acquisition process repeated two to three times at increasing intensities. highly accelerated (R = 7-8 for cine R 16 flow) data reconstructed inline Gadgetron-based compressed sensing reconstruction. In agreement with literature, ejection...