A5002034165- Advanced MRI Techniques and Applications
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Protein Interaction Studies and Fluorescence Analysis
- Alzheimer's disease research and treatments
- MRI in cancer diagnosis
- Antimicrobial Peptides and Activities
- Barrier Structure and Function Studies
- Electron Spin Resonance Studies
- Advanced biosensing and bioanalysis techniques
- Lanthanide and Transition Metal Complexes
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Neuroimaging Techniques and Applications
- Vestibular and auditory disorders
- Polydiacetylene-based materials and applications
- Advanced NMR Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Monetary Policy and Economic Impact
- Molecular Sensors and Ion Detection
- Protein Structure and Dynamics
- Market Dynamics and Volatility
- Biochemical and Structural Characterization
- Advanced Polymer Synthesis and Characterization
- Occupational and environmental lung diseases
- Cell Adhesion Molecules Research
Lovely Professional University
2019-2025
Calyx (India)
2024
Spinverse (Finland)
2020-2021
Aalto University
2010-2020
University of Turku
2020
Yes Technologies (United States)
2019
PAREXEL International (United States)
2018
Perceptive Engineering (United Kingdom)
2013
University of Helsinki
2006-2010
University of New Mexico
2005-2009
Increased permeability of the blood-brain barrier (BBB) is important in neurological disorders. Neuroinflammation associated with increased BBB breakdown and brain injury. Tumor necrosis factor (TNF)-α involved injury edema formation through a mechanism involving matrix metalloproteinase (MMP) up-regulation. There emerging evidence indicating that cyclooxygenase (COX) inhibition limits disruption following ischemic stroke bacterial meningitis, but mechanisms are not known. We used...
We evaluated performance characteristics and estimated the minimal clinically important difference (MCID) of data-driven texture analysis (DTA), a high-resolution computed tomography (HRCT)-derived measurement lung fibrosis, in subjects with idiopathic pulmonary fibrosis (IPF). The study population included 141 IPF from two interventional clinical trials who had both baseline nominal 54- or 60-week follow-up HRCT. DTA scores were compared forced vital capacity (FVC), diffusing for carbon...
Proteolytic disruption of the extracellular matrix with opening blood—brain barrier (BBB) because metalloproteinases (MMPs) occurs in reperfusion injury after stroke. Matrix metalloproteinase inhibition blocks early BBB, but long-term consequences short-term MMP are not known. Recently, a method to quantify BBB permeability by graphical methods was described, which provides way study both and effects on recovery same animal. We used broad-spectrum inhibitor, BB1101, determine usefulness...
Matrix metalloproteinase-9 (MMP-9) and NADPH oxidase contribute to blood-brain barrier (BBB) disruption after ischemic stroke. We have previously shown that normobaric hyperoxia (NBO) treatment reduces MMP-9 oxygen free radical generation in brain. In this study, we tested the hypothesis NBO protects BBB through inhibiting oxidase-mediated induction transient focal cerebral ischemia. Male Sprague-Dawley rats (n = 69) were given (95% O2) or normoxia (21% during 90-min filament occlusion of...
Direct drug delivery to the cochlea is associated with risk of irreversible damage ear. In this study, liposome and polymersome nanoparticles (NPs), both formed from amphiphilic molecules (lipids in liposomes block copolymers polymersomes), were tested as potential tools for via application onto round window membrane adult mice (strain C3H). One day after application, types NPs labeled fluorescent markers identified spiral ganglion all cochlear turns without producing any distinct...
Purpose This study investigates the impact of quality, technology and trust on customers’ purchase intentions word-of-mouth in S-commerce. Design/methodology/approach Data were collected from 1,162 respondents India using a quantitative methodology convenience sampling. The conceptual model hypotheses examined partial least squares structural equation modeling (PLS-SEM). Findings findings illustrate that perceived value is influenced by trust. Comprehending essential for influencing buying...
White matter (WM) injury after bilateral common carotid artery occlusion (BCAO) in rat is associated with disruption of the blood—brain barrier (BBB) by matrix metalloproteinases (MMPs). We hypothesized that WM as seen on magnetic resonance imaging (MRI) would correlate regions increased MMP activity. MRI was performed 3 days BCAO surgery rats. Apparent diffusion coefficients (ADC) were calculated and vascular permeability quantified multiple-time graphical analysis (MTGA) method, using...
Abstract Purpose To compare water and a polyethylene glycol (PEG) preparation as potential oral contrast media for magnetic resonance imaging (MRI) of the small bowel. Materials Methods Twenty‐two healthy volunteers underwent separate MRI examinations after drinking up to two liters or PEG preparation. Small bowel images were obtained every 10 minutes at least hours using breath‐hold single shot half‐Fourier imaging, including both thick section projection thin images. Examinations evaluated...
Treatment of inner ear diseases remains a problem because limited passage through the blood-inner barriers and lack control with delivery treatment agents by intravenous or oral administration. As minimally-invasive approach, intratympanic multifunctional nanoparticles (MFNPs) carrying genes drugs to is future therapy for treating diseases, including sensorineural hearing loss (SNHL) Meniere's disease. In an attempt track dynamics distribution in vivo, here we describe manufacturing MRI...
The goal of this study was to evaluate the impact liposome nanocarrier size on efficacy its transport across middle-inner ear barriers.The dynamic distribution nanocarriers encapsulating gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (LPS+Gd-DOTA) sizes 95, 130, and 240 nm were observed with a 4.7 T magnetic resonance machine after transtympanic injection in Wistar rats. Histology performed confocal microscopy using TRITC conjugated LPS+Gd-DOTA. integrity LPS+Gd-DOTA transportation...
Background: The alcohol‐preferring (P) rat, a Wistar strain selectively bred to consume large amounts of alcohol voluntarily, has been used as an animal model human alcoholism for 3 decades. Heretofore, knowledge about brain morphology confined postmortem examination. Quantitative neuroimaging procedures make it feasible examine the potential longitudinal effects exposure in vivo, while controlling modifying factors, such age, nutrition, and exercise. To date, few imaging studies have...
Several techniques are available for making large unilamellar vesicles (LUV) with an average diameter of approximately 100 nm, widely employed as model biomembranes well vehicles drug delivery. Here we describe the use adaptive focused ultrasound (AFU) preparation LUV from multilamellar (MLV) and studied effects intensity number cycles per burst (CPB) on size produced. CPB determines duration intermittent pressure wavetrains emitted by transducer, corresponding relaxation periods....
To validate a novel sustained delivery system of liposome nanocarriers for inner-ear therapy and to investigate the transport pathway their delivery.Liposome containing gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (LPS+Gd-DOTA) were developed MRI tracking in vitro release profile vivo uptake studies.Encapsulating Gd-DOTA did not modify liposomes. The LPS+Gd-DOTA slowly released from miniature osmotic pump. moved along ossicular chain toward oval window after an epitympanic injection,...
Oxidized phospholipids occur naturally in conditions of oxidative stress and have been suggested to play an important role a number pathological due their effects on lipid membrane acyl chain orientation, ordering, permeability. Here we investigate the effect oxidized phospholipid 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PazePC) model 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) using combination (13)C-(1)H dipolar-recoupling nuclear magnetic resonance (NMR) experiments...
Electron paramagnetic resonance imaging (EPRI) is a new modality for visualizing O(2) distribution in tissues, such as the brain after stroke or administration of drugs abuse. We have recently shown that 3-acetoxymethoxycarbonyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl [1] pro-imaging agent can cross blood-brain barrier. After hydrolysis by esterases, anion 3-carboxy-2,2,5,5-tetramethyl-1-tetramethyl-1-pyrrolidinyloxyl [2] trapped tissue. In this study, we investigated feasibility using to map...
Background: Tracking the dynamic course of human alcoholism brain pathology can be accomplished only through naturalistic study and without opportunity for experimental manipulation. Development an animal model alcohol‐induced damage, in which animals consume large amounts alcohol following cycles access deprivation are examined regularly with neuroimaging methods, would enable hypothesis testing focused on degree, nature, factors resulting damage prospects recovery or relapse. Methods: We...