A5024341193- Protein Interaction Studies and Fluorescence Analysis
- Alzheimer's disease research and treatments
- Lipid Membrane Structure and Behavior
- Protein Structure and Dynamics
- Molecular Sensors and Ion Detection
- Computational Drug Discovery Methods
- DNA and Nucleic Acid Chemistry
- Enzyme Structure and Function
- Metal complexes synthesis and properties
- Lanthanide and Transition Metal Complexes
- Advanced Fluorescence Microscopy Techniques
- Nanoparticle-Based Drug Delivery
- Spectroscopy and Quantum Chemical Studies
- Molecular spectroscopy and chirality
- Advanced biosensing and bioanalysis techniques
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Supramolecular Self-Assembly in Materials
- Electrochemical Analysis and Applications
- Proteins in Food Systems
- Drug Transport and Resistance Mechanisms
- Dye analysis and toxicity
- Click Chemistry and Applications
- Photochemistry and Electron Transfer Studies
- Advanced Glycation End Products research
V. N. Karazin Kharkiv National University
2016-2025
University of North Texas
2010
Texas Christian University
2010
University of North Texas Health Science Center
2010
Pavlov Institute of Physiology of the Russian Academy of Sciences
1976
Fluorescence represents one of the most powerful tools for detection and structural characterization pathogenic protein aggregates, amyloid fibrils. The traditional approaches to identification quantification fibrils are based on monitoring fluorescence changes benzothiazole dye thioflavin T (ThT) absorbance azo Congo red (CR). In routine screening it is usually sufficient perform only ThT CR assays, but both them, when used separately, could give false results. Moreover, fibrillization...
Novel cyanine dyes can be used for amyloid fibril detection.
The applicability of a series novel benzanthrone dyes to monitoring the changes in physicochemical properties lipid bilayer and differentiating between native aggregated protein states has been evaluated. Based on quantitative parameters dye-membrane dye-protein binding derived from fluorimetric titration data, most prospective membrane probes amyloid tracers have selected group examined compounds. Analysis red edge excitation shifts membrane- amyloid-bound provided information sites within...
The energy transfer chain consisting of four fluorochromes is capable differentiating between the amyloid and non-fibrillized states insulin.