Abstract: A novel particulate delivery matrix based on ionically crosslinked casein (CAS) nanoparticles was developed for controlled release of the poorly soluble anticancer drug flutamide (FLT). Nanoparticles were fabricated via oil-in-water emulsification then stabilized by ionic crosslinking positively charged CAS molecules below their isoelectric point, with polyanionic crosslinker sodium tripolyphosphate. With optimal preparation conditions, loading and incorporation efficiency achieved...

Abstract Background Complex coronary artery disease still a major health problem, whether high-risk PCI on V-A ECMO or not is better choice. Aim and objectives The study designed to assess the outcomes of using procedures. Patients methods A prospective interventional performed patients with viable ischemic myocardium who refused CABG, syntax score>22, excluding scarred myocardium. (Fem-Fem configuration) will be initiated during elective procedure, compared underwent refusing ECMO, also...

Abstract Background COVID-19 is a disease that affects multiple organs and believed to have an impact on the function of heart muscle. Initial findings from hospitalized patients indicate presence myocardial injury characterized by increased levels high-sensitive troponin. The causes damage are diverse not completely comprehended. Methods A three-dimensional echocardiogram (3DE) accurately measures volume left ventricle (LV) its function, both globally regionally. It eliminates subjective...

To date, various drugs as host modulating agents had been suggested adjunctive treatment modality in the therapy of chronic periodontal disease. In this study, anti-inflammatory effect subgingivally delivered nanostructured doxycycline gel (nDOX) was evaluated and compared to conventional (DOX) used adjunct scaling root planning (SRP) moderate periodontitis reduce probing pocket depth.Nanostructured prepared using spray-drying technique with chitosan (CH) a matrix polymer, followed by...

Aims. To evaluate the effect of Punica granatum (Pg) rind extract and its spray dried biopolymeric dispersions with casein (F1) or chitosan (F2) against Diabetes mellitus (DM) diabetic neuropathy (DN). Methods. We measured acute (6 h) subacute (8 days) various doses Pg, F1, F2 active compounds on alloxan-induced DM mouse model. evaluated DN utilizing latency tests for longer period time weeks). In addition, in vivo antioxidant activity was assessed serum catalase level. Results. The results...

Novel α-bisabolol (BIS)-loaded citric acid cross-linked zein nanofibrous scaffolds (C-ZNFs) were proposed to serve as safe platforms for promoting wound repair in rats.ZNFs synthesized using electrospinning technique, then NFs, with adequate water resistance, produced a cross-linker.Compared the uncross-linked ZNFs, cross-linking 7% w/w decreased swelling index by 3 folds, while tensile strength and contact angle enhanced 2.5 3.8 respectively. SEM images showed beads-free homogeneous NFs...

Oral lichen planus (OLP) is a chronic disease with immune-mediated pathogenesis. Selenium (Se), an antioxidant, plays role in modulating immunity. The aim of this clinical trial was to evaluate two Se forms (novel topical hydrogel and oral capsules), solely, treating erosive OLP based on evaluation salivary oxidative stress markers. Patients were allocated into one three groups: group I, corticosteroids; II, Se; III, systemic Se. Treatment lasted for 6 weeks; patients clinically evaluated at...

Background: Sulpiride (SUL), is a selective antidopaminergic drug that had extensive biological activities. However, its sparingly aqueous solubility and limited gastrointestinal permeability lead to scanty oral bioavailability which hinders clinical efficacy. Objective: SUL-loaded lipospheres (SUL-LPS) were designed serve as an biocompatible nanovector for improving SUL well conquering low absorption then in turn enhancing antidepressant action. Methods: SUL-LPS fabricated via two...

Study the possible benefit of combining biodegradable polymers with sildenafil citrate (SC) in wound healing.Biodegradable micronized powdered formulations SC were prepared by spray drying using chitosan (P₁) or chitosan/gum Arabic (P₂). Powders characterized differential scanning calorimetry, Scanning electron microscope, particle size analysis, flow and swelling behavior. The powders also incorporated into microstructured gels vitro release from was tested. In vivo healing acceleration...

Purpose: Desvenlafaxine succinate (DSV) is a water soluble anti-depressant drug, which rapidly absorbed after oral administration exaggerating its side effects. The current work aimed to prepare controllable release DSV matrix reduce effects related initial burst. Methods: Fifteen formulations were prepared using different polymers, polymer/drug ratios and excipients characterized Differential Scanning Calorimetry (DSC), infrared (IR) spectroscopy, uptake in vitro release. kinetics...

The use of different drug classes as host modulating agents has been postulated to have significance an adjunctive remedy curing chronic periodontitis. In this study nano-structured films containing doxycyclin (DOX) were evaluated for such purpose. Nano DOX/chitosan particulate system was prepared using spray drying technique and then incorporated in PVA-based films. particles particle size, zeta potential possible drug/polymer interaction. also tested in-vitro release clinical efficacy...

Flutamide (FLT) is the only presently recommended drug for monotherapy of benign prostatic hypertrophy. It known its poor solubility and slow dissolution. In this study nine different formulae liquisolid systems (LS) were prepared using Polyethyleneglycol 400 as a liquid vehicle, Avicel® PH 102 Aerosil 200 carrier coating material, respectively. Hydrophilic polymers (PVP, HPMC PEG 2000) added at 10% w/w concentration to improve LS properties. Thermal analysis showed complete absence...