A5012172467- Berberine and alkaloids research
- Synthesis and biological activity
- Hepatitis C virus research
- Parasites and Host Interactions
- Alkaloids: synthesis and pharmacology
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Hepatitis B Virus Studies
- Drug-Induced Hepatotoxicity and Protection
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- Essential Oils and Antimicrobial Activity
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory mediators and NSAID effects
- Immune Cell Function and Interaction
- Parasite Biology and Host Interactions
- Research on Leishmaniasis Studies
- Streptococcal Infections and Treatments
- Plant tissue culture and regeneration
- Drug Solubulity and Delivery Systems
- Alzheimer's disease research and treatments
- vaccines and immunoinformatics approaches
- Tryptophan and brain disorders
- Quinazolinone synthesis and applications
- Cancer Mechanisms and Therapy
City of Scientific Research and Technological Applications
2014-2024
Alexandria University
1999-2024
Helwan University
2024
Technology Applications (United States)
2014-2022
Biotechnology Research Institute
2022
University of Sadat City
2018
King Abdulaziz University
2004
Ain Shams University
1999
University of California, Berkeley
1999
University of Tennessee at Knoxville
1997-1999
Abstract Background Berberis vulgaris is a well known plant with traditional herbal medical history. The aims of this study was to bioscreen and compare the in vitro biological activity (antioxidant, cholinergic, antidaibetic anticancer) barberry crude extract berberine active compound. Methods effect B. chloride on cellular thiobarbituric acid reactive species (TBARS) formation, diphenyle–α-picrylhydrazyl (DPPH) oxidation, nitric oxide (NO) radical scavenging capability, superoxide...
Abstract Berberine (BBR) is an isoquinoline alkaloid with several clinical therapeutic applications. Its low water solubility, absorption, and cellular bioavailability diminish BBR's efficacy. In this study, BBR was encapsulated into bovine serum albumin nanoparticles (BSA NPs) core to reduce limitations enhance its properties. Several physicochemical characterization tools, such as Dynamic Light Scattering Ultraviolet–Visible spectroscopic measurements, field emission transmission electron...
Background —Discrepancies in reported HLA class II associations with rheumatic heart disease (RHD) may have been due to inaccuracies of serological typing reagents and/or lack defined clinical classification patients analyzed. The molecular association between and RHD was investigated outcome. Methods Results —Class allele/haplotype distribution determined 2 groups (n=88) a control group (n=59). Patients were divided into the mitral valve (MVD) category (ie, those regurgitation or without...
In the context of searching for potent, safe, natural antimicrobial agents to combate global resistance (AMR) phenomenon, current study evaluates first time ever, broad-spectrum activity essential oil (EO) and extracts from rare wild plant Centaurea pumilio L.. It has tremendous ethnomedicinal values; its dried root is used as a fattening agent, treatment bad breath diabetes, screened schistosomicidal activity.C. EO was extracted by hydrodistillation using Clevenger apparatus. Chemical...
Abstract Two new acetylpyridinehydrazones derived from cyanoacetic acid hydrazide have been synthesized namely: (1‐pyridin‐3 or 4‐yl‐ethylidene) hydrazides ( 1a,b ). and some ring systems: 2‐imino 2‐oxo‐2 H ‐chromenes 2a,b 3a,b ), substituted 2‐thioxo‐2,3‐dihydrothiazoles 4a–d 2‐thioxo‐2,3‐dihydro‐6 ‐thiazolo[4,5‐ d ]pyrimidin‐7‐ones 5a–d dihydrothiazoles 7a,b 2‐oxo‐1,2‐dihydropyridines 8a–d 9a,b Fifteen compounds were evaluated for their anticancer activity using the USA‐NCI in‐vitro...
Biotransformations are having great potential to generate novel or known products more efficiently. Berberine (BB) represents one of the most studied among naturally occurring protoberberine alkaloids due its wide range pharmacological activities. Firstly, isolate BB from Berberis vulgaris roots, semisynthesis berberrubine (M1). Secondly, investigate liability and M1 for biotransformation by cell cultures Ocimum basilicum Dodonaea viscosa focusing on production potent hepatoprotective...
To establish a cell culture system with long-term replication of hepatitis C virus (HCV) genome and expression viral antigens in vitro.HepG2 line was tested for its susceptibility to HCV by incubation serum from patient chronic C. Cells supernatant were harvested at various time points during the culture. Culture ability infect naive cells. The presence minus (antisense) RNA strand, detection core E1 cells examined RT-PCR immunological techniques (flow cytometry Western blot)...
Alcea rosea L. is widely cultivated in gardens of Egypt as an ornamental plant and it has a great history folkloric medicinal uses. In the present work, phytochemical investigation alcoholic extract flowers A. led to isolation six flavonoids (1-6). Dihydrokaempferol-4'-O-β-d-glucopyranoside (1), dihydrokaempferol (2), kaempferol-3-O-[6″-(E-coumaroyl)]-β-d-glucopyranoside (3), kaempferol-3-O-β-d-glucopyranoside (4), Apigenin (5) kaempferol-3-O-α-l-rhamnopyranosyl-(1'″→6″)-β-d-glucopyranoside...
Berberine is a plant alkaloid that has several pharmacological effects such as antioxidant, antilipidemic, and anti-inflammatory effects. Nonalcoholic steatohepatitis (NASH) triggers different aspects of disorders impaired endogenous lipid metabolism, hypercholesterolemia, oxidative stress, neurotoxicity. In this study, we examined the mechanism by which NASH induces neurotoxicity protective effect berberine against both its associated induced rats showed significant impairments in...
The medicinal potential of marine invertebrates' bioactive components that may act as anti-COVID-19 demonstrated promising results. Ophiocoma dentata, which is common in the Red Sea, one such source. Therefore, this study aimed to isolate a new compound from brittle star, and evaluate its efficacy in-silico in-vitro. Standard procedures were followed order assess isolated compound's preliminary toxicity anti-inflammatory properties. Computer virtual screening technology through molecular...
Aims: In the past, herbs were only source of most drugs; ethnopharmacological research may represent a crucial step in development drugs from natural sources. Trial and error have led to correlation particular herb with amelioration and/or complete curing certain diseases. Ginger (Zingiber officinale, Zingiberaceae) has been widely used as dietary spice, traditional oriental drug. The rhizome ginger contains pungent vanillyl ketones, including [6]-gingerol [6]-paradol, which credited...
Abstract Purpose Non-alcoholic fatty liver disease is the most prevalent metabolic disorder that can lead to development of non-alcoholic steatohepatitis (NASH) and, eventually, result in hepatocellular carcinoma. This study evaluated therapeutic potential berberine-loaded bovine serum albumin nanoparticles (BBR-BSA NPs) toward induced NASH physical, biochemical, and ultrastructural changes. Methods was male rats by an high-fat high-sucrose diet (HFHSD) repeated carbon tetrachloride (CCl 4 )...