Background: Cyclophosphamide (CP) (Cytoxan or Endoxan) is an efficient anti-tumor agent, widely used for the treatment of various neoplastic diseases. The study aimed to investigate protective role vitamin E (vit E) in improving cardiotoxicity rats induced by CP. Materials and methods: Forty male Wistar were divided randomly into four experimental groups (each consisting ten rats); control group was treated with saline. other three vit E, CP, combination Serum lipid profiles, enzyme cardiac...

A study on the corrosion and scaling inhibition efficiencies of some amine derivatives for carbon steel.

Ultraviolet C (UVC) devices are an effective means of disinfecting surfaces and protecting medical tools against various microbes, including coronavirus. Overexposure to UVC can induce oxidative stress, damage the genetic material, harm biological systems. This study investigated prophylactic efficacy vitamin B12 hepatotoxicity in UVC-intoxicated rats. Rats were irradiated with (725.76, 967.68, 1048.36 J/cm2) for 2 weeks. The rats pretreated aforementioned antioxidants two months before...

Rubinstein-Taybi syndrome (RTS) is a well-defined characterized by facial abnormalities, broad thumbs, big toes, and growth mental retardation as the main clinical features. RTS was shown to be associated with disruption of CREB–binding protein gene CBP (CREBBP), either gross chromosomal rearrangements or point mutations. Translocations inversions involving chromosome band 16p13.3 form minority mutations, whereas microdeletions occur more frequently (about 10%). Most deletion studies in are...

Abstract Purpose Non-alcoholic fatty liver disease is the most prevalent metabolic disorder that can lead to development of non-alcoholic steatohepatitis (NASH) and, eventually, result in hepatocellular carcinoma. This study evaluated therapeutic potential berberine-loaded bovine serum albumin nanoparticles (BBR-BSA NPs) toward induced NASH physical, biochemical, and ultrastructural changes. Methods was male rats by an high-fat high-sucrose diet (HFHSD) repeated carbon tetrachloride (CCl 4 )...

Abstract Developmental toxicities, including birth defects, are significant public health problems. This study was planned to assess the cholinergic and developmental potentials of diazinon that is widely used as an organophosphate insecticide. Pregnant female Sprague‐Dawley rats were given orally at doses 0, 1.9, 3.8, 7.6 mg/kg body weight (b.w.)/day on gestation days 6 15. Maternal brain acetylcholinesterase activities, measured day20, significantly decreased 3.8 b.w./day, but fetal...

Background: Nanotechnology application has widespread use in many products. Copper nanoparticles (CuNPs) are widely used industrial applications. The present study was conducted to investigate the effect of ethanolic saffron extract (ESE) as a natural antioxidant on hepatotoxicity induced by CuNPs male mice. Methods: characterization determined using ultraviolet–visible absorption spectroscopy, particle size analysis, zeta potential, Fourier-transform infrared and electron microscope. mice...

Corrosion inhibitive performance of some thiophene derivatives during the acidic corrosion carbon steel surface in 1 M HCl was investigated by chemical technique (weight loss) and electrochemical techniques (potentiodynamic polarization, frequency modulation, impedance spectroscopy). The effect temperature on rate weight loss method, thermodynamic parameters for adsorption processes were determined discussed. results show that inhibition efficiency increased with increase inhibitor...

To evaluate the protective effect of beta-carotene on induction diabetes by streptozotocin (STZ), 45 albino rats, weighed about 110-130 g were used. They divided randomly into six groups. GI rats used as control; GII injected i.p. with a single dose 40 mg (STZ) to become diabetic; GIII and GIV, diabetic 0.3 0.1 beta-carotene, respectively; GV GVI only respectively. At end experiment, final body weights, blood glucose insulin levels determined values statistically analyzed. Histological,...

The present study was designed to evaluate the toxic effects induced by different time intervals of methomyl exposure on liver antioxidant defense system, oxidative stress, function biomarkers and histopathology in CD-1 mice. Ten male mice per group were assigned one four treatment groups. Group served as control while 2, 3 4 orally treated with mg methomyl/kg BW for 10, 20 30 days, respectively. Results obtained showed that significantly TBARS decreased activity enzymes, glutathione...

Hepatocellular carcinoma (HCC) is one of the most fatal solid malignancies. Recently, emergence immune checkpoint inhibitor (ICI) has revolutionized HCC therapeutic regimens. Galectins (Gal-) 1,3,9 have been casted as recent checkpoints. Yet, tumors highly packed with immunosuppressive mediators such Interleukins (IL-),6,10 that act formidable barrier for any cell to attack tumor. Long non-coding RNAs (LncRNAs) a new class ncRNAs possess capability influence various facets tumor...

Abstract Ginkgo extract, EGb 761 is known as a vasoregulatory variable for the conventional reproduction therapy. was orally administered in 0 (control), 3.7, 7.4, and 14.8 mg/kg bw/day 28 days (thereafter mated with normal fertile male), from day 1 to 7 of pregnancy or 10th 18th pregnancy, respectively. Vaginal smears were performed daily. On 20th females killed by cervical dislocation their kidneys, liver, brain, placenta, spleen ovaries removed weighed. The prepared histological...

Abstract Environmental and health issues are critical challenges for sustainable development in the 21st century; therefore, this paper investigates a simple cost-effective process recovery of organic matter (OM) from phosphoric acid to provide environmentally acceptable P-fertilizer. This study analyzed structural transformations adsorption properties Na-bentonite clay before after chemical activation by sulfuric hydrochloric acids. The untreated treated samples have been used high strength...