A5079060508- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Heterocycles
- Synthesis of Organic Compounds
- Synthesis and biological activity
- Click Chemistry and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Quinazolinone synthesis and applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Conducting polymers and applications
- Organic Chemistry Cycloaddition Reactions
- Chemical Synthesis and Analysis
- Organic Chemistry Synthesis Methods
- Fluorine in Organic Chemistry
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Inorganic and Organometallic Chemistry
- Organic Electronics and Photovoltaics
- Chemical Synthesis and Reactions
- Synthesis and pharmacology of benzodiazepine derivatives
- Oxidative Organic Chemistry Reactions
- Organophosphorus compounds synthesis
- Electrochemical Analysis and Applications
- Structural and Chemical Analysis of Organic and Inorganic Compounds
Taibah University
2015-2024
Alexandria University
2009-2024
Northern Arizona University
2005-2006
State Key Laboratory of Synthetic Chemistry
1993-2004
Beirut Arab University
2004
United Arab Emirates University
1988-1999
University of Cincinnati
1985-1998
Institute of Health Visiting
1991
Mississippi State University
1986-1990
Al-Azhar University
1989
Efficient regioselective synthesis of nucleoside conjugates was achieved by cycloaddition reaction azides and alkynes using sodium ascorbate/CuSO 4 system as a catalyst. These 16 novel thymidine analogues were obtained in excellent yields (75–100%), employing mild conditions with broad scope structural modification. For the compounds tested, no specific antiviral effects could be witnessed against range viruses.
A library of 16 3-benzyl-N1-substituted quinoxalin-2-ones was synthesized as N1-substituted quinoxalines and quinoxaline-triazole hybrids via click reaction. These compounds were tested for their anticancer activity MTT assay on HCT-116 normal colonocyte cell lines to assess cytotoxic potentials safety profiles. Overall, 6, 9, 14, 20 found be promising anticolorectal cancer agents; they exhibited remarkable cytotoxicity (IC50 0.05–0.07 μM) against cells within safe doses (EC100) colon cells....
In this study, 18 new 3‐benzylquinoxalinyl hydrazones bearing carbohydrate moiety and their corresponding triazoloquinoxalines were synthesized in order to investigate possible antibacterial antifungal activities. Some of these compounds such as 4b , 4c 7b 7c 7d showed promising activities found have more potent activity compared with that standard drugs. From structure–activity relationship point view, increasing the size substitutions at position 6 or 7 on quinoxaline nucleus decreased...
Abstract Some hindered bithienyl derivatives have been synthesized by cross-coupling reaction of Grignard reagents using NiCl2(dppp)(dppp = Ph2PCH2CH2CH2PPh2) or reductive dimerization in the presence Zn/NiCl2(PPh3)2. Their UV spectra and oxidation potentials are discussed terms their coplanarity inductive effect substituent.
Abstract A series of 1‐aryl‐ s ‐triazolo[4,3‐ a ]quinoxalin‐4‐ones, 3 , were synthesized via the pyrolysis corresponding hydrazones, 6 . Thus, cyclodehydrogenation occurred by refluxing them in an inert solvent (e.g. ethylene glycol) to give triazoloquinoxalin‐4‐ones satisfactory yield. Using DMSO as for above transformation afforded minor by‐product S ‐ylid. In contrast earlier findings, annelation six‐membered ring was successful and achieved through pyruvate hydrazones derived...
Abstract magnified image Phthalaldehydic acid 1 is often represented as having two tautomeric forms 1a and 1b. The reaction of phthalaldehydic with different aryl amine heterocyclic hydrazine derivatives afforded products depending on the conditions such solvent temperature.
The chemical polymerization of (2,5‐dibromo‐3‐substituted) thiophenes utilizing as a copromoter yields an amorphous insoluble polymer fraction which exhibits very high electronic conductivity varying between 10−1 to 102S‐cm. These materials have been used electrode materials. redox chemistry the Cu(II) containing in contact with supporting electrolyte only shows distinct internal (Cu(II)/Cu(I) cyclic voltammetric wave. No behavior for thiophene ring system is observed. This material stable...
The reactton of 14ydrazinophthakzine (11 with palycarbonyl compounds depends on the acid and acidity reaction as well structure carbonyl components.The I-hydrazinophthalazine (1) compounds, especially concerning its role in human metabolism mvolving reactions Krebs cycle carbanyl is an intensely researched field.'-l7In continurng cur interest m this particular area view a number discrepancies literature arrlgnmentr products I certain we reinvestigated mare detail 1,3-dicarbonyl...
Abstract Annelation reactions of six‐membered rings to 1‐hydrazinophthalazine, 1, were investigated. With aroyl‐(acyl)pyruvates, 2, the desired system was obtained. It found that course reaction depends on condition as well substituted pyruvates. Thus, 3‐(2‐oxo‐2‐substituted ethyl)‐4 H ‐as‐triazino‐[3,4‐ a ]phthalazin‐4‐one, 4, product when 1 reacted with 2 in alcoholic medium. The side chain tauto‐merism 4 studied by using ir, H‐nmr, and ms spectral methods. When hydrochloride instead...
A series of new pyridazinylacetic acid derivatives were synthesized and have been investigated for their ability to inhibit the activity B isoforms monoamine oxidase (MAO). All compounds found be more selective MAO-A isoform with compound 5d having highest SI values. Computational study performed a docking technique indicated potential these in pyridazine-based inhibitor drug development.
Abstract The condensation reaction between α‐keto‐β‐aroyl (or acyl) ‐γ‐butyrolactones, 4a‐4e and o ‐phenylenediamine or 2, 3‐diaminonaphthalene leads under retrograde aldol involving loss of formaldehyde to formation 3‐substituted‐3, 4‐dihydro‐2 (1 H ) quinoxalinones benzo [ g ] quinoxalinones, 7a‐7g , respectively as a new convenient synthesis this type heterocyclic systems. 4 compound with 4, 5‐diaminopyromidine, 8 was found proceed differently....