A5039635084- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactions of Organic Compounds
- Cancer therapeutics and mechanisms
- Quinazolinone synthesis and applications
- Multicomponent Synthesis of Heterocycles
- Bioactive Compounds and Antitumor Agents
- Click Chemistry and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cancer Mechanisms and Therapy
- Synthesis of heterocyclic compounds
- Antibiotics Pharmacokinetics and Efficacy
- Computational Drug Discovery Methods
- Metal complexes synthesis and properties
- Inflammatory mediators and NSAID effects
- Synthesis and Reactivity of Heterocycles
- X-ray Diffraction in Crystallography
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Crystallization and Solubility Studies
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Epigenetics and DNA Methylation
- Fluorine in Organic Chemistry
- Statistical Distribution Estimation and Applications
Al-Azhar University
2013-2025
Al-Azhar University
2006-2025
Helwan University
2024
Madurai Kamaraj University
2024
Abbott (United States)
2023
Cairo University
2005-2017
Madras Medical College
2014
National Research Centre
1988-1997
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear that deregulated in obesity. PPARγ exerts diverse antineoplastic effects. Attempting to determine the clinical relevance of epigenetic mechanisms controlling expression and susceptibility colorectal cancer (CRC) obese subjects, this study investigated role some microRNAs DNA methylation on deregulation PPARγ. Seventy CRC patients (34 36 lean), 22 24 lean healthy controls were included. MicroRNA levels measured serum....
Abstract This study intends to develop a novel bioactive chitosan Schiff base (CTS-SB) derivative via coupling of (CTS) with 4-((5, 5-dimethyl-3-oxocyclohex-1-en-1-yl) amino) benzene-sulfonamide. The alteration in the chemical structure CTS-SB was verified using 1 H NMR and FT-IR analysis, while thermal morphological properties were inspected by TGA SEM characterization tools, respectively. Ion exchange capacity developed recorded maximal value 12.1 meq/g compared 10.1 for pristine CTS. In...
Condensation of 4-benzoyl-1,2-phenylenediamine with sodium pyruvate in acetic acid furnished two products which were identified as 6-benzoyl and 7-benzoyl-3-methyl-2(1H)quinoxalinones (1a,b). Fusion 1a aromatic aldehydes the styryl derivatives 2a-c. Alkylation 1a,b dimethyl sulphate or ethyl chloroacetate produced N-alkyl 3a,b 4a,b. Hydrazinolysis ester derivative 4a hydrazine hydrate afforded hydrazide 5 underwent condensation to give corresponding hydrazone 6a,b. In addition, chlorination...
With the aim of developing novel antitumor scaffolds, a series polysubstituted pyrazole derivatives linked to different nitrogenous heterocyclic ring systems at C-4 position were synthesized through chemical reactions and characterized by means spectral elemental analyses their antiproliferative activity against 60 human tumor cell lines was validated U.S. National Cancer Institute using two stage process. The in vitro anticancer evaluation revealed that compound 9 showed increased potency...
A new series of 4-alkyl/aryl-2-oxo-1-pyrazolyl-1,2-dihydropyridine-3-carbonitriles, pyrazolo[3,4-b]pyridine-5-carbonitriles and pyrido[2,3-d]pyrimidine-6-carbonitriles have been synthesized tested for their anti-inflammatory analgesic activities. Among the compounds, 3e 8b exhibited comparable activity to standard (indomethacin). Compounds 5, 7a, displayed potent activity. Detailed syntheses, spectroscopic biological data are reported.
Self-assembled [Ag( 5NO 2 Qu ) ]BF 4 and Qu3CN )(H O)]BF were analysed with Hirshfeld surfaces tested for antimicrobial properties.
The EGFR/PI3K/Akt/mTOR pathway is important for metastasis, medication resistance, apoptosis prevention, and malignant transformation.
Design and synthesis of novel hybrids Passerini adducts tethered with 1,2,3-triazoles as promising dual anti-inflammatory antioxidant agents.
Design and synthesis of some novel pyrazoline pyranopyrazole derivatives as potential anti‐inflammatory agents are described. Most the compounds were tested for their ( in vitro vivo ) ulcerogenic activities. In all compounds, it was found that pyrazolines, 2a , pyrazolopyrano[2,3‐ d ]pyrimidine 9 potent selective cyclooxygenase‐2 (COX‐2) inhibitor. All mainly safe level. Docking study revealed higher affinity binding with active site COX‐2 enzyme like SC‐558, a
A library of 16 3-benzyl-N1-substituted quinoxalin-2-ones was synthesized as N1-substituted quinoxalines and quinoxaline-triazole hybrids via click reaction. These compounds were tested for their anticancer activity MTT assay on HCT-116 normal colonocyte cell lines to assess cytotoxic potentials safety profiles. Overall, 6, 9, 14, 20 found be promising anticolorectal cancer agents; they exhibited remarkable cytotoxicity (IC50 0.05–0.07 μM) against cells within safe doses (EC100) colon cells....
Facile synthesis of molecular hybrids containing a 2,4-dinitrophenyl moiety was achieved via nucleophilic aromatic substitution the fluoride anion Sanger's reagent (2,4-dinitrofluorobenzene) with various N, S, and O nucleophiles, considered as bioactive moieties. Antimicrobial evaluation new carried out using amoxicillin nystatin antibacterial antifungal reference standards, respectively. MIC test results identified compounds 3, 4, 7 most active against standard strains multidrug-resistant...
Thirteen diarylurea derivatives were designed and synthesized as sorafenib mimetics.
Vascular endothelial growth factor receptor-2 is a vital target for therapeutic mediation in various types of cancer. This study was aimed at exploring the cytotoxic activity seventeen novel quinoxaline-3-propanamides against colon cancer (HCT-116) and breast (MCF-7) using MTT assay. Results revealed that compounds 8, 9, 14 elicited higher cytotoxicity than reference drugs, doxorubicin (DOX) sorafenib. Interestingly, they are more selective HCT-116 (SI 11.98-19.97) MCF-7 12.44-23.87)...
A novel series of pyrrolo[2,3-d] pyrimidines bearing sulfonamide moieties have been synthesized and tested for their antitumor activity. Among them, compounds 4, 8b, 8d, 8g 14 showed promising Moreover, compound 8d exhibited radioprotective The structures the newly were established by elemental analyses spectral data.