A5020280426- Liver Disease Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Liver Disease and Transplantation
- Hepatitis C virus research
- Colorectal Cancer Surgical Treatments
- Axon Guidance and Neuronal Signaling
- Alzheimer's disease research and treatments
- Connective tissue disorders research
- Neuroinflammation and Neurodegeneration Mechanisms
- Central Venous Catheters and Hemodialysis
- Viral Infections and Vectors
- Hepatocellular Carcinoma Treatment and Prognosis
- Nerve injury and regeneration
- Gastric Cancer Management and Outcomes
- Psoriasis: Treatment and Pathogenesis
- Hepatitis Viruses Studies and Epidemiology
- Endoplasmic Reticulum Stress and Disease
- Horticultural and Viticultural Research
- Wnt/β-catenin signaling in development and cancer
- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Nuclear Receptors and Signaling
- Agricultural Science and Fertilization
- Organ Transplantation Techniques and Outcomes
- Machine Learning in Healthcare
Zagazig University
1985-2024
Baptist Hospital
2024
Saint Thomas Midtown Hospital
2024
Mansoura University
2024
Tanta University
2023
Morriston Hospital
2023
Universität Hamburg
2017-2022
University Medical Center Hamburg-Eppendorf
2017-2022
Hamad General Hospital
2012-2021
Hospital for Tropical Diseases
2021
The migration of mesencephalic dopaminergic (mDA) neurons from the subventricular zone to their final positions in substantia nigra compacta (SNc), ventral tegmental area (VTA), and retrorubral field (RRF) is controlled by signalling neurotrophic factors, cell adhesion molecules (CAMs) extracellular matrix (ECM). Reelin cytoplasmic adaptor protein Disabled-1 (Dab1) have been shown play important roles positioning mDA neurons. Mice lacking Dab1 both display phenotypes characterised failure...
The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV (OI-XV) has suggested that is a key ligand promoting the differentiation and function bone-forming osteoblasts. Although such an influence was supported by subsequent studies, mouse model OI-XV remained to be established. Therefore, we introduced previously identified disease-causing mutation (G177C) into murine Wnt1 gene. Homozygous Wnt1G177C/G177C mice were viable did not display...
Foot ulceration (FU) remains a serious concern for patients worldwide. We analyzed the incidence, risk factors, and outcome of FU in hemodialysis (HD) patients. A retrospective cohort study was conducted 252 HD who were followed up 5 years. Patients categorized according to whether they developed or not. The group (17%) older had significantly higher incidence nephropathy, retinopathy, peripheral (PAD), coronary artery disease (CAD), diabetes mellitus (DM) as compared no-FU group. frequency...
The cell adhesion molecule L1 and the extracellular matrix protein Reelin play crucial roles in developing nervous system. is known to activate signalling cascades regulating neuronal migration by binding lipoprotein receptors. However, interaction of with molecules, such as L1, has remained poorly explored. Here, we report that full-length its N-terminal fragments N-R2 N-R6 bind fragment proteolytically cleave generate an a molecular mass 80 kDa (L1-80). Expression generation L1-80 coincide...
We investigated the distribution patterns of extracellular matrix protein Reelin and crucial signaling components in murine midbrain striatum. The cellular receptors VLDLr ApoER2, intracellular downstream mediator Dab1, alternative receptor APP were analyzed at embryonic day 16, postnatal stage 15 (P15), 3-month-old mice. was expressed intracellularly extracellularly mesencephalic dopaminergic (mDA) neurons newborns. In striatum, Calbindin D-28k+ exhibited E16 P15 3 months. ApoER2 mDA...
The endocannabinoid system (ECS) consists particularly of cannabinoid receptors 1 and 2 (CB1 CB2), their endogenous ligands, enzymes that synthesize degrade ligands. It acts in a variety organs disease states ranging from cancer progression over neuropathic pain to neurodegeneration. Protein components engaged the signaling, trafficking, homeostasis machinery G-protein coupled CB2, are however largely unknown. is therefore important identify further interaction partners better understand CB2...
Vitiligo is a common skin disorder resulting from the destruction of melanocytes. Hepatitis C virus (HCV) infection has been linked to variety extrahepatic manifestations, including diseases.To measure prevalence HCV-seroreactivity among vitiligo patients.This cross-sectional study included 108 patients. Serum anti-HCV antibodies were detected by chemiluminescence immunoassay.Eighteen patients (16.7%) out HCV-reactive; all them had adult-onset vitiligo. They represented approximately 34.6%...
Background and study aim: Current guidelines recommend antibiotic prophylaxis for all cirrhotic patients with variceal bleeding. However, the low infection rate in Child-A raises concerns about overuse. This investigates impact of this population. Patients Methods: We conducted a prospective 312 cirrhosis experiencing their first hemorrhage. received either standard treatment (n=152) or plus seven days intravenous ceftriaxone (n=160). All underwent upper endoscopy band ligation. Results:...
We evaluated the prevalence, predictors, and outcome of peripheral arterial disease (PAD) among hemodialysis (HD) patients (n = 252) in a prospective study (3-year follow-up) conducted Qatar. Those with PAD 97; 38.5%) were older more likely to be males have diabetes mellitus, prior coronary artery (CAD), or cerebrovascular disease. Diabetic retinopathy was an independent predictor (adjusted odds ratio: 2.7; P .004). Women had higher mortality. Three-year all-cause mortality high group hazard...
Background The COVID-19 pandemic has sparked a surge in the use of virtual communication tools for delivering clinical services many non-urgent medical needs allowing telehealth or telemedicine, to become an almost inevitable part patient care. However, most patients with vascular disease may require face-to-face interaction and are at risk worse outcomes if not managed timely manner. Objective We aimed describe utilization telemedicine outpatient surgery clinics tertiary hospital. Methods A...
Abstract The study sought to investigate the impact of a holistic high-power microwave technology during all stages extraction on quality, time extraction, and degree deacetylation (DD) shrimp chitosan (SC) crab (KC). demineralization deproteinization took 7 8 min, at 750 875 W, respectively. process was conducted two powers, W 1250 for 10, 15, 20 min. It only 25 min successfully prepare with high DD 30 reach maximum DD. highest DDs by potentiometric titration method, FTIR, 1 H NMR SC were...
ABSTRACT Since a key function of Wnt1 in brain development was established early on through the generation non-viable Wnt1-deficient mice, it initially surprising that WNT1 mutations were found to cause either early-onset osteoporosis (EOOP) or osteogenesis imperfecta type XV (OIXV). The deduced as an osteoanabolic factor has been confirmed various mousemodels with bone-specific inactivation overexpression, but mice carrying disease-causing have not yet described. Triggered by clinical...
Data evaluating the presence and impact of diabetic retinopathy (DR) in patients on regular hemodialysis (HD) are scarce.To assess prevalence outcomes DR HD patients.Data were collected from 252 consecutive HD-dependent who underwent eye examination for detection 2007. Patients divided into two groups (DR vs. no-DR) followed up 3 years. Demographic clinical profiles analyzed compared. Multivariate logistic regression was used to find out predictors DR, morbidity mortality.DR diagnosed 113...
We aimed to study the vascular outcomes in hemodialysis (HD) patients based on their diabetic status. A cohort observational was conducted among undergoing regular HD with a 5-year follow-up. Of 252 consecutive patients, 60% were diabetic. Compared nondiabetics, diabetics 11 years older, 4 lesser HD, and more likely have prior cerebrovascular coronary artery disease (CAD). Overall follow-up showed that had higher rates of accesses (57% vs 41%, P = .01), CAD (64% 33%, .001), major amputations...
Abstract Background Many studies and organizations described bases of pregnancy timing after bariatric surgeries, but there is still a need for uniform scientific evidence accurate timing. We aimed to assess outcomes neonatal findings by surgery compare adverse perinatal among women who underwent prior with those had not. Patients methods included 200 pregnant females previously performed different surgeries. All were divided into three groups: early group patients conceived ≤ 12 months from...
Serotonin (5-HT) acts as both a morphogenetic factor during early embryonic development and neuromodulator of circuit plasticity in the mature brain. Dysregulation serotonin signaling critical periods is involved developmental neurological disorders, such schizophrenia autism. In this study we focused on consequences defect reelin for brainstem serotonergic raphe system. We observed that components are expressed by neurons period their lateral migration. Further, found important normal...
Rare coding variants in the triggering receptor expressed on myeloid cells-2 (TREM2) gene have been associated with Alzheimer disease (AD) and homozygous TREM2 loss-of-function reported families monogenic frontotemporal-like dementia with/without bone abnormalities. In a whole-exome sequencing study of family probable AD-type without pathogenic known autosomal dominant genes negative for apolipoprotein E (APOE) ε4 allele, we identified an extremely rare variant, that is,...
Background Despite the fact that endoscopy is gold standard for screening of high-risk varices (HRVs) in patients with compensated cirrhosis, it invasive, costly and not necessary all patients. So, noninvasive tests can replace endoscopy. We aimed at evaluating albumin-bilirubin-platelet (ALBL-PLT) score as a test predicting HRVs cirrhotic versus Baveno VI extended criteria. Methods cirrhosis ( n = 204) were included. Laboratory parameters, esophagogastroduodenoscopy (EGD) liver stiffness...