A5065180565- Connective tissue disorders research
- Total Knee Arthroplasty Outcomes
- Bone health and osteoporosis research
- Orthopaedic implants and arthroplasty
- Wnt/β-catenin signaling in development and cancer
- Orthopedic Infections and Treatments
- Hip and Femur Fractures
- Bone Metabolism and Diseases
- TGF-β signaling in diseases
- Bone and Joint Diseases
- MicroRNA in disease regulation
- Bone health and treatments
- Knee injuries and reconstruction techniques
- Orthopedic Surgery and Rehabilitation
- Epigenetics and DNA Methylation
- Bone fractures and treatments
- Shoulder Injury and Treatment
- Fibroblast Growth Factor Research
- Lung Cancer Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Electrical and Bioimpedance Tomography
- Sports injuries and prevention
- Hematological disorders and diagnostics
- Hernia repair and management
Universität Hamburg
2020-2024
University Medical Center Hamburg-Eppendorf
2020-2024
Suizhou Central Hospital
2019-2023
Renji Hospital
2020
Shanghai Jiao Tong University
2013-2020
Chongqing Medical University
2019
Sichuan University
2014-2016
West China Hospital of Sichuan University
2014-2016
Ruijin Hospital
2013
Serial assessment of the biomechanical properties tissues can be used to aid early detection and management pathophysiological conditions, track evolution lesions evaluate progress rehabilitation. However, current methods are invasive, only for short-term measurements, or have insufficient penetration depth spatial resolution. Here we describe a stretchable ultrasonic array performing serial non-invasive elastographic measurements up 4 cm beneath skin at resolution 0.5 mm. The conforms human...
The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV (OI-XV) has suggested that is a key ligand promoting the differentiation and function bone-forming osteoblasts. Although such an influence was supported by subsequent studies, mouse model OI-XV remained to be established. Therefore, we introduced previously identified disease-causing mutation (G177C) into murine Wnt1 gene. Homozygous Wnt1G177C/G177C mice were viable did not display...
To observe the clinical results of proximal femoral nail anti-rotation (PFNA) combined with zoledronic acid injection in treatment osteoporotic intertrochanteric fractures elderly.60 elderly patients were diagnosed using a dual energy X-ray bone density instrument. Patients randomly divided into or control groups (30 cases each group). both treated by closed/open reduction and internal fixation PFNA. In group, received one phosphonic 5 mg/100 ml via intravenous drip, addition to 600 mg...
Abstract Skeletal growth, modeling, and remodeling are regulated by various molecules, one of them being the recently identified osteoanabolic factor WNT1. We have previously reported that WNT1 transcriptionally activates expression Omd, encoding Osteomodulin (OMD), in a murine mesenchymal cell line, which potentially explained skeletal fragility mice with mutational inactivation, since OMD has been shown to regulate type I collagen fibril formation vitro. In this study we confirmed strong...
ABSTRACT Since a key function of Wnt1 in brain development was established early on through the generation non-viable Wnt1-deficient mice, it initially surprising that WNT1 mutations were found to cause either early-onset osteoporosis (EOOP) or osteogenesis imperfecta type XV (OIXV). The deduced as an osteoanabolic factor has been confirmed various mousemodels with bone-specific inactivation overexpression, but mice carrying disease-causing have not yet described. Triggered by clinical...
Objective To compare the clinical efficacy of direct anterior approach in lateral decubitus position (L‐DAA) and supine (S‐DAA) for unilateral total hip arthroplasty. Methods A retrospective study was conducted on 89 patients who underwent primary arthroplasty our department between August 2016 December 2017. There were 46 L‐DAA 43 S‐DAA. The body mass index (BMI), operation time, blood loss, preoperative Hb, first day third postoperative incision length, hospital stay, Harris score, visual...
The bone matrix is constantly remodeled by the coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts. Whereas type I collagen most abundant protein, there are several other proteins present, some them specifically produced osteoblasts. In a genome-wide expression screening for osteoblast differentiation markers we have previously identified two collagen-encoding genes with unknown function in remodeling. Here show that one them, Col22a1, predominantly expressed...
Objective To compare the clinical efficacy of direct anterior approach in lateral decubitus position (L-DAA) and posterolateral (PLA) for unilateral total hip arthroplasty. Methods A retrospective study was conducted on 93 patients who underwent primary arthroplasty Department Joint Surgery, Suining Central Hospital between August 2016 December 2017. The replacement were included bilateral or intolerance surgery excluded. There 45 cases L-DAA 48 PLA. body mass index(BMI), operation...
Objective To evaluate the effects of total extraperitonal herniorrhaphy on pain and effusion in patients with surgical area. Methods The clinical data 58 cases inguinal hernia admitted to First Hospital Shanxi Medical University from January 2017 2018 were retrospectively analyzed.Complete extraperitoneal oblique repair was performed under laparoscopy general anesthesia.The divided into two groups by single or double admission date number.The observation group(A group, 32 cases)...