A5089746618- Cellular Mechanics and Interactions
- Elasticity and Material Modeling
- Composite Material Mechanics
- Cellular and Composite Structures
- Metal Forming Simulation Techniques
- Mechanical Behavior of Composites
- 3D Printing in Biomedical Research
- High-Velocity Impact and Material Behavior
- Rheology and Fluid Dynamics Studies
- Fatigue and fracture mechanics
- Planarian Biology and Electrostimulation
- Photoacoustic and Ultrasonic Imaging
- Tendon Structure and Treatment
- Blood properties and coagulation
- Pluripotent Stem Cells Research
- Force Microscopy Techniques and Applications
- Ultrasound Imaging and Elastography
- Neuroscience and Neural Engineering
- Venomous Animal Envenomation and Studies
- Structural Response to Dynamic Loads
- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Polymer Foaming and Composites
- Orthopaedic implants and arthroplasty
- Electrical and Bioimpedance Tomography
University of Pennsylvania
2015-2023
University of Southern California
2019-2020
Lehigh University
1988
Serial assessment of the biomechanical properties tissues can be used to aid early detection and management pathophysiological conditions, track evolution lesions evaluate progress rehabilitation. However, current methods are invasive, only for short-term measurements, or have insufficient penetration depth spatial resolution. Here we describe a stretchable ultrasonic array performing serial non-invasive elastographic measurements up 4 cm beneath skin at resolution 0.5 mm. The conforms human...
Abstract Cell-generated tractions play an important role in various physiological and pathological processes such as stem-cell differentiation, cell migration, wound healing, cancer metastasis. Traction force microscopy (TFM) is a technique for quantifying cellular during cell–matrix interactions. Most applications of this have heretofore assumed that the matrix surrounding cells linear elastic undergoes infinitesimal strains, but recent experiments shown traction-induced strains can be...
Many biological materials contain fibrous protein networks as their main structural components. Understanding the mechanical properties of such is important for creating biomimicking cell and tissue engineering, developing novel tools detecting diagnosing disease. In this work, we develop continuum models isotropic, athermal by combining a single-fibre model that describes axial response individual fibres, with network assemble fibre into overall behaviour. particular, consider four...
Electrical stimulation (ES) within a conductive scaffold is potentially beneficial in encouraging the differentiation of stem cells toward neuronal phenotype. To improve cell-based regenerative therapies, it essential to use electroconductive scaffolds with appropriate stiffnesses regulate amount and location ES delivery. Herein, biodegradable substrates different are fabricated from chitosan-grafted-polyaniline (CS-g-PANI) copolymers. Human mesenchymal (hMSCs) cultured on soft show...
The mechanical properties of tissues play a critical role in their normal and pathophysiological functions such as tissue development, aging, injury, disease. Understanding mechanics is important not only for designing realistic biomimetic materials engineering drug testing but also developing novel diagnostic techniques medical interventions. Tissues are heterogeneous consisting cells confined within extracellular matrices (ECMs), both which derive structural integrity, at least part, from...
Deoxyribonucleic acid (DNA) evolved as a tool for storing and transmitting genetic information within cells, but outside the cell, DNA can also serve "construction material" present in microbial biofilms or various body fluids, such cystic fibrosis, sputum, pus. In work, we investigate mechanics of formed from Pseudomonas aeruginosa Xen 5, Staphylococcus aureus 30, Candida albicans 1408 using oscillatory shear rheometry at different levels compression recreate these systems entangled cells....
Sponges are animals that inhabit many aquatic environments while filtering small particles and ejecting metabolic wastes. They composed of cells in a bulk extracellular matrix, often with an embedded scaffolding stiff, siliceous spicules. We hypothesize the mechanical response this heterogeneous tissue to hydrodynamic flow influences cell proliferation manner generates body sponge. Towards more complete picture emergence sponge morphology, we dissected set species subjected discs living...
Abstract Many biological materials contain fibrous protein networks as their main structural components. Understanding the mechanical properties of such is important for creating biomimicking cell and tissue engineering, developing novel tools detecting diagnosing disease. In this work, we develop continuum models isotropic, athermal by combining a single-fiber model that describes axial response individual fibers, with network assemble fiber into overall behavior. particular, consider four...
In a typical experiment in compression elastography sample is compressed to an overall strain of about 1-5%, and then perturbed with much smaller the range 0.05%-0.1%. The displacement field corresponding this perturbative excitation measured using phase-sensitive OCT. This three-dimensional data carries within it wealth information regarding volumetric distribution linear elastic properties tissue. talk we will describe class iterative algorithms that use input generate maps biological...
Rheology and the study of viscoelastic materials are an integral part engineering biophysical systems. Tissue rheology is even used in cancer other diseases. However, cost a rheometer feasible only for colleges, universities, research laboratories. Even if can be purchased, it bulky delicately calibrated, limiting its usefulness to laboratory itself. The design presented here less than tenth professional rheometer. also portable, making ideal solution introduce viscoelasticity high school...
Variations in the mechanical properties of extracellular environment can alter important aspects cell function such as proliferation, migration, differentiation and survival. However, many techniques available to study these effects lack ability characterise cell-to-cell cell-to-environment interactions on microscopic scale three dimensions (3D). Quantitative micro-elastography (QME) is an extension compression optical coherence elastography that utilizes a compliant layer with known...
Tractions exerted by cells on the extracellular matrix (ECM) are critical in many important physiological and pathological processes such as embryonic morphogenesis, cell migration, wound healing, cancer metastasis. Tract... | Find, read cite all research you need Tech Science Press
Abstract Tractions exerted by cells on the extracellular matrix (ECM) are critical in many important physiological and pathological processes such as embryonic morpho-genesis, wound healing, cancer metastasis. Three-dimensional Traction Microscopy (3DTM) is a tool to quantify cellular tractions first measuring displacement field ECM response these tractions, then using this measurement infer tractions. Most applications of 3DTM have assumed that has spatially-uniform mechanical properties,...