A5023140554- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Advanced Drug Delivery Systems
- Pluripotent Stem Cells Research
- Chromatin Remodeling and Cancer
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Planarian Biology and Electrostimulation
- Genomics and Chromatin Dynamics
- Nuclear Structure and Function
- Wound Healing and Treatments
- Blood properties and coagulation
- Innovative Microfluidic and Catalytic Techniques Innovation
- Periodontal Regeneration and Treatments
- Cellular Mechanics and Interactions
- Polydiacetylene-based materials and applications
- Graphene and Nanomaterials Applications
- Silk-based biomaterials and applications
- Neonatal Respiratory Health Research
- Nanoparticle-Based Drug Delivery
- Oral microbiology and periodontitis research
- Ear Surgery and Otitis Media
- Antimicrobial Peptides and Activities
- Antimicrobial agents and applications
- Mesenchymal stem cell research
University of Pennsylvania
2020-2024
Amirkabir University of Technology
2017-2024
Abstract Incomplete regeneration and restoration of function in damaged nerves is a major clinical challenge. In this regard, stem cells hold much promise nerve tissue engineering, with advantages such as prevention scar‐tissue ingrowth guidance axonal regrowth. Engineering 3D patterned microenvironments using biomaterials chemical mechanical characteristics close to those normal nervous has enabled new approaches for guided differentiation various toward neural possible treatment...
Abstract Decellularized scaffolds have been found to be excellent platforms for tissue engineering applications. The attempts are still being made optimize a decellularization protocol with successful removal of the cells minimal damages extracellular matrix components. We examined twelve procedures using different concentrations Sodium dodecyl sulfate and Triton X-100 (alone or in combination), incubation time points 15 30 min. Then, potential decellularized scaffold as three-dimensional...
A conductive chitosan/polyaniline hydrogel with cell-imprinted topography was used for neural priming of adipose derived stem cells.
Effective communication between immune and bone-forming cells is crucial for the successful healing of bone defects. This study aimed to assess potential a decellularized placental sponge (DPS) as coculture system inducing M1/M2 polarization in macrophages promoting osteogenic differentiation adipose-derived mesenchymal stem (AD-MSCs), both vitro vivo. We prepared DPS conducted comprehensive characterization its biomechanical properties, antibacterial activity, biocompatibility. In vitro, we...
Electrical stimulation (ES) within a conductive scaffold is potentially beneficial in encouraging the differentiation of stem cells toward neuronal phenotype. To improve cell-based regenerative therapies, it essential to use electroconductive scaffolds with appropriate stiffnesses regulate amount and location ES delivery. Herein, biodegradable substrates different are fabricated from chitosan-grafted-polyaniline (CS-g-PANI) copolymers. Human mesenchymal (hMSCs) cultured on soft show...
The structure and dynamics of the cell nucleus regulate nearly every facet cell. Changes in nuclear shape limit motility gene expression. Although is generally seen as stiffest organelle cell, cells can nevertheless deform to large strains by small mechanical stresses. Here, we show that response exhibits active fluidization driven BRG 1 motor SWI/SNF/BAF chromatin-remodeling complex. Atomic force microscopy measurements alters stiffness substrate stiffness, which retained after isolated...
Intravenous drug delivery is an advantageous choice for rapid administration, immediate effect, and avoidance of first-pass metabolism in oral delivery. In this study, the synthesis, formulation, characterization atorvastatin-loaded polyurethane (PU) nanoparticles were investigated intravenous route administration.First, PU was synthesized characterized. Second, prepared four different ratios to polymer through two techniques, including emulsion-diffusion single-emulsion. Finally, particle...
Abstract Smart nano-environments that mimic the stem cell niche can guide behavior to support functional repair and regeneration of tissues. The specific microenvironment nervous tissue is composed several physical signaling factors, including proper topography, flexibility, electric conductance. In this study, a cell-imprinting technique was used obtain hierarchical topographical conductive scaffold based on chitosan-polyaniline (PANI) hydrogels for directing neural differentiation rat...
Abstract Electrical stimulation (ES) within conductive polymer substrates has been suggested to promote the differentiation of stem cells toward a neuronal phenotype. The use scaffolds in tissue regeneration provides unique and attractive new option control amount location ES delivery. Scaffold stiffness also shown be an important regulator cells’ behavior fate. Therefore, improve cell-based regenerative therapies, it is essential characterize simultaneous effects electroconductive substrate...