A5009855140- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystal structures of chemical compounds
- Synthesis and biological activity
- Crystallography and molecular interactions
- Metal complexes synthesis and properties
- Synthesis of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Organometallic Compounds Synthesis and Characterization
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Reactions of Organic Compounds
- Magnetism in coordination complexes
- Metal-Organic Frameworks: Synthesis and Applications
- Fluorine in Organic Chemistry
- Molecular Sensors and Ion Detection
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Chemical Synthesis and Analysis
- Nonlinear Optical Materials Research
- Lanthanide and Transition Metal Complexes
- Organometallic Complex Synthesis and Catalysis
- Synthesis and Biological Evaluation
- Synthesis and Reactivity of Heterocycles
- Multicomponent Synthesis of Heterocycles
- Quinazolinone synthesis and applications
Universiti Sains Malaysia
2013-2025
King Saud University
2011-2025
Hospital Universiti Sains Malaysia
2007-2016
Nanjing University
2002-2016
Mansoura University
2016
National Center for Health Research
2016
Egyptian Atomic Energy Authority
2016
Alexandria University
2016
University of Benin
2016
Institute of Medicinal Plant Development
2016
In modern drug designing, molecular docking is routinely used for understanding drug-receptor interaction. the present study six imidazole derivatives containing substituted pyrazole moiety (2a,b and 4a–d) were synthesized. Structures of newly synthesized compounds characterized by spectral studies. Compounds screened their antibacterial activity. Compound 4c was found to be potent antimicrobial against Pseudomonas aeruginosa at concentrations 1 0.5 mg/mL compared standard Streptomycin. All...
Our designed chemosensor, rhodamine-HBT-dyad (RHD), selectively detects two biologically important ions (Al<sup>3+</sup> and Zn<sup>2+</sup>) at different wavelengths (red green, respectively) through FRET ESIPT <italic>in vitro</italic> vivo</italic>.
A new fluorescence rhodamine derivative bearing an 8-aminoquinoline moiety has been designed and synthesized for selective sensing of Pd2+ in the presence other competing metal ions aqueous media. induced spirolactam ring opening is confirmed first time by X-ray crystal structure bound Pd2+-complex.
By employing the oxidation property of hypochlorite (OCl(-)), a novel rhodamine-based hydrazide chiral acid ((S)-(-)-2-pyrrolidone-5-carboxylic acid) (RHHP) was designed and synthesized for detection OCl(-) absolutely in aqueous medium at nanomolar level. The structure sensor also proved by X-ray crystallography. bioactivity application probe natural water system have been demonstrated. A plausible mechanism followed hydrolysis is proposed. sensibility receptor toward studied absolute media,...
A nickel-catalyzed direct sulfenylation of unactivated arenes using removable 2-(pyridine-2-yl)-isopropylamine as a directing group has been developed.
Polysulfone nanofiltration membranes containing sulfated nano-titania (S-TiO<sub>2</sub>) were fabricated, with the aim to enhance membrane properties along possible rejection of Methylene Blue (MB) dye by membranes.
A novel 8-fold interpenetration diamondoid-like chiral condensed neutral coordination polymer, bis{4-[2-(4-pyridyl)ethenyl]benzoato}zinc [Zn(PEBA)2] 1, synthesized by the hydrothermal reaction between Zn(ClO4)2·6H2O and 4-[2-(4-pyridylethenyl)]benzenecarbonitrile (PEBC), displays very strong blue fluorescent emission SHG response (ca. 1.5 × that of urea) as well high thermal stability (up to ca. 430 °C).
A solvated complex of alpha-H(4)SiW(12)O(40).4HMPA.2H(2)O composed the heteropolytungstate alpha-H(4)SiW(12)O(40) and organic substrate hexamethylphosphoramide (HMPA) has been synthesised, purified, characterized. The electronic spectra (lambda = 220-500 nm) as well (1)H NMR for title compound dissolved in CD(3)CN establish that this dissociates into free SiW(12)O(40)(4)(-) HMPA moieties solution unless is present very high concentrations. solid reflectance IR indicate there interaction...
The first terephthalato (TPT) bis-tridentate bridging cadmium coordination polymer, [(TPT)(py)Cd] 1, with blue fluorescent emission, was synthesized by a hydrothermal reaction between Cd(ClO4)2· 6H2O, 1,4-dicyanobenzene and pyridine (py).
Synthesis and characterization of new heterocyclic pyrazole chalcones (4a–e) diamide (6a–e) derivatives are described. Pyrazole were synthesized by the reaction aldehydes suitable aromatic ketones. Diamides phthalic acid amines. Newly compounds characterized spectral studies their biological activity was assessed in vitro using MCF-7 (human breast adenocarcinoma) HeLa cervical tumor cells) cell lines. Few molecules inhibited growth human cancer lines at low micromolar to nanomolar concentrations.
A new fluorescent probe was synthesized from rhodamine-6G and 6-(hydroxymethyl) picolinohydrazide for the sensing of Fe3+ in an aqueous environment. The structure sensor confirmed through its single crystal X-ray study. It exhibits a high specificity sensitivity towards over other interfering heavy transition metal ions (HTM). turn-on greenish-yellow fluorescence colorimetric change colourless to pink were observed upon addition which evokes almost 116- 23-fold enhancement absorbance...
On the basis of Förster resonance energy transfer mechanism between rhodamine and quinoline–benzothiazole conjugated dyad, a new colorimetric as well fluorescence ratiometric probe was synthesized for selective detection Cd2+. The complex formation with Cd2+ confirmed through Cd2+-bound single-crystal structure. Capability imaging agent to detect cellular uptake demonstrated here using living RAW cells.
In the present study a series of new Schiff bases were synthesized. All synthesized compounds characterized by IR, 1H NMR, mass spectral and elemental analyses. Newly screened for their antibacterial (Staphylococcus aureus, Bacillus subtilis, Escherichia coli Pseudomonas aeruginosa) activity. The results revealed that, 3f 3c have exhibited significant biological activity against tested microorganisms.
We have designed a chemodosimeter DPNO (weak fluorescence) which can be oxidized to HPNO (strong blue by OCl− with high selectivity and sensitivity in ratiometric approach noticeably lower detection limit. The sensor could useful for the of hypochlorites tap water.
A series of six novel heterocyclic chalcone analogues 4(a-f) has been synthesized by condensing 2-acetyl-5-chlorothiophene with benzaldehyde derivatives in methanol at room temperature using a catalytic amount sodium hydroxide. The newly compounds are characterized IR, mass spectra, elemental analysis and melting point. Subsequently; the structures these were determined single crystal X-ray diffraction. All screened for their antioxidant potential employing various vitro models such as DPPH...
Cobalt-catalyzed decarboxylative cross-coupling of oxazoles and thiazoles with α-oxocarboxylic acids was developed through an sp(2) C-H bond functionalization process. This work represents the first example cobalt-catalyzed provides efficient means building some important bioactive heteroaryl ketone derivatives.
We have synthesised a probe for the fluorescence ratiometric detection of Al<sup>3+</sup>. This can be used to image Al<sup>3+</sup> in living cells.