A5040307540- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Prenatal Substance Exposure Effects
- Nicotinic Acetylcholine Receptors Study
- Birth, Development, and Health
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Cannabis and Cannabinoid Research
- Fatty Acid Research and Health
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Genetic Neurodegenerative Diseases
- Biochemical Analysis and Sensing Techniques
- Neurological disorders and treatments
- Pharmacological Receptor Mechanisms and Effects
- Neurogenesis and neuroplasticity mechanisms
- Metabolism and Genetic Disorders
- Peroxisome Proliferator-Activated Receptors
- Stress Responses and Cortisol
- Amino Acid Enzymes and Metabolism
- Pain Mechanisms and Treatments
- Alzheimer's disease research and treatments
King Saud University
2018-2024
University of Toledo
2015-2024
Io Therapeutics (United States)
2024
Indiana University School of Medicine
2000-2022
Indiana University – Purdue University Indianapolis
2000-2022
Temple University
2022
Indiana University Bloomington
2008-2011
Indiana University
2004-2008
Sorbonne Université
1997-2004
Centre National de la Recherche Scientifique
1997-2004
Relapse to cocaine-seeking behavior depends on increased glutamate transmission in key regions of the mesocorticolimbic motive circuit, including prefrontal cortex (PFC) and nucleus accumbens (NAcc). Because GLT1 is responsible for uptake ≥90% extracellular glutamate, we tested hypothesis that expression attenuates cocaine relapse. Rats were trained self-administer (0.125 mg per intravenous infusion) a lever-pressing task daily 2 h session 10–14 d followed by 5 extinction training....
The purpose of this work was to develop a multiparticulate system exploiting the pH-sensitive property and biodegradability calcium alginate beads for intestinal delivery ceftriaxone sodium (CS). CS entrapped in made carboxymethylcellulose (CMC), acacia, HPMC K4M K15M as drug release modifiers. Beads were prepared using chloride cross-linking agent, followed by enteric coating with cellulose acetate phthalate (CAP). then evaluated entrapment efficiency HPLC, vitro examined simulated gastric...
Changes in glutamatergic transmission affect many aspects of neuroplasticity associated with ethanol and drug addiction. For instance, ethanol- drug-seeking behavior is promoted by increased glutamate key regions the motive circuit. We hypothesized that because transporter 1 (GLT1) responsible for removal most extracellular glutamate, up-regulation or activation GLT1 would attenuate consumption.Alcohol-preferring (P) rats were given 24 h/day concurrent access to 15 30% ethanol, water food 7...
Relapse-like ethanol-drinking behavior depends on increased glutamate transmission in the mesocorticolimbic motive circuit. Extracellular is regulated by a number of transporters. Of these transporters, transporter 1 (GLT1) responsible for majority extracellular uptake. We have recently reported that ceftriaxone (CEF) treatment (i.p.), β-lactam antibiotic known to elevate GTL1 expression, reduced ethanol intake male alcohol-preferring (P) rats. investigated here whether CEF attenuates...
Hepatotoxicity caused by chemotherapeutic drugs (e.g., doxorubicin) is of critical concern in cancer therapy. This study focused on investigating the modulatory effects diosmin against doxorubicin-induced hepatotoxicity Male Wistar rats. rats were randomly divided into four groups: Group I was served as control, II treated with doxorubicin (20 mg/kg, intraperitoneal, i.p.), III a combination and low-dose (100 mg/kg orally), IV high-dose (200 orally) supplementation. A single dose (i.p.)...
Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by cortico-striatal dysfunction and loss of glutamate uptake. At 7 weeks age, R6/2 mice, which model aggressive form juvenile HD, show a glutamate-uptake deficit in striatum that can be reversed treatment with ceftriaxone, beta-lactam antibiotic increases GLT1 expression. Only at advanced ages (> 11 weeks), however, do mice actual striatal GLT1. Here, we tested whether ceftriaxone reverse the decline...
We have recently shown that upregulation of glutamate transporter 1 (GLT1) in the brain is associated part with reduction ethanol intake alcohol-preferring (P) male rats. In this study, we investigated effects a synthetic compound, (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153), known to activate GLT1 on consumption as well expression and certain signaling pathways P rats were given 24-h concurrent access 15 30% ethanol, water food for 5 weeks. On week 6, received MS-153 at dose 50...