A5101724106- Neurotransmitter Receptor Influence on Behavior
- Prenatal Substance Exposure Effects
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Receptor Mechanisms and Signaling
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
- Neonatal and fetal brain pathology
- Pluripotent Stem Cells Research
- Telomeres, Telomerase, and Senescence
- Axon Guidance and Neuronal Signaling
- Neurological Disorders and Treatments
- Amino Acid Enzymes and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cerebrospinal fluid and hydrocephalus
- Ion channel regulation and function
- Adipose Tissue and Metabolism
- Neuroscience and Neural Engineering
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
Indiana University – Purdue University Indianapolis
2006-2023
Indiana University School of Medicine
2006-2023
Neurosciences Institute
2013-2014
California State University, Stanislaus
2013
Indiana University Bloomington
2013
Heilongjiang Institute of Technology
2011
Pediatrics and Genetics
2011
Harbin Institute of Technology
2011
University of South Carolina
2005
Texas A&M University System
2005
Potential epigenetic mechanisms underlying fetal alcohol syndrome (FAS) include alcohol-induced alterations of methyl metabolism, resulting in aberrant patterns DNA methylation and gene expression during development. Having previously demonstrated an essential role for epigenetics neural stem cell (NSC) development that inhibiting prevents NSC differentiation, here we investigated the effect exposure on genome-wide differentiation.Neural cells culture were treated with or without a 6-hour 88...
During hippocampal development, the Cornus Ammonis (CA) and dentate gyrus (DG) undergo waves of neurogenesis neuronal migration maturation independently. This stage is widely known to be vulnerable environmental stresses, but its underlying mechanism unclear. Alcohol exposure has been shown alter expression genes that regulate fate, survival, differentiation pyramidal granule cells. Undermining this process might compromise development learning memory deficits in Fetal Spectrum Disorders...
We have previously demonstrated that alcohol exposure at early neurulation induces growth retardation, neural tube abnormalities, and alteration of DNA methylation. To explore the global gene expression changes which may underline these developmental defects, microarray analyses were performed in a whole embryo mouse culture model allows control over embryonic variables.Alcohol caused teratogenesis brain, heart, forelimb, optic vesicle; subset embryos also showed cranial defects. In analysis...
The physical repair and restoration of a completely damaged pathway in the brain has not been achieved previously. In previous study, using excitatory amino acid bridging fetal neural transplantation, we demonstrated that bridged mesencephalic transplant substantia nigra generated an artificial nerve reinnervated striatum 6-hydroxydopamine (6-OHDA)-lesioned rats. current report can anatomically, neurochemically, functionally reinstate 6-OHDA-eradicated nigro-striatal pathway. An acid, kainic...
Preservation of neural stem cells (NSCs) in the adult peripheral nervous system (PNS) has recently been confirmed. However, it is not clear whether NSCs possess predestined, bona fide phenotypes or a response to innate developmental cues. In this study, we first demonstrated longevity, multipotency, and high fidelity sensory features postmigrating dorsal root ganglia (aDRG) cells. Derived from aDRG after 4–5 years culture without dissociating, were found capable proliferation, expressing...
Abstract BACKGROUND: Epigenetic changes are believed to be among the earliest key regulators for cell fate and embryonic development. To support this premise, it is important understand whether or not systemic epigenetic coordinate with progression of We have demonstrated that DNA methylation programmed when neural stem cells differentiate (Zhou et al., 2011 ). Here, we analyzed events occur during early tube METHODS AND RESULTS Using immunocytochemistry, marks – 5‐methylcytosine (5‐MeC),...
Background: Dopaminergic (DA) activity in the extended amygdala (EA) has been known to play a pivotal role mediating drug and alcohol addiction. Alterations of DA within EA after chronic exposure or substances abuse are considered major mechanism for development alcoholism To date, it is not clear how different patterns drinking affect receptor levels. Therefore, current studies investigated effects ethanol consumption, with without deprivations, on D1 D2 densities EA. Methods: Inbred...