A5061990101- Chemotherapy-induced cardiotoxicity and mitigation
- Colorectal Cancer Treatments and Studies
- Neutropenia and Cancer Infections
- Cancer Treatment and Pharmacology
- Cell death mechanisms and regulation
- Alzheimer's disease research and treatments
- Nanoparticles: synthesis and applications
- Gut microbiota and health
- Hematopoietic Stem Cell Transplantation
- Heat shock proteins research
- Retinoids in leukemia and cellular processes
- Zebrafish Biomedical Research Applications
- Computational Drug Discovery Methods
- Blood disorders and treatments
- RNA regulation and disease
- Inflammatory Bowel Disease
- Chronic Myeloid Leukemia Treatments
- Angiogenesis and VEGF in Cancer
- Endoplasmic Reticulum Stress and Disease
King Saud University
2021-2022
Batterjee Medical College
2021
Hepatotoxicity caused by chemotherapeutic drugs (e.g., doxorubicin) is of critical concern in cancer therapy. This study focused on investigating the modulatory effects diosmin against doxorubicin-induced hepatotoxicity Male Wistar rats. rats were randomly divided into four groups: Group I was served as control, II treated with doxorubicin (20 mg/kg, intraperitoneal, i.p.), III a combination and low-dose (100 mg/kg orally), IV high-dose (200 orally) supplementation. A single dose (i.p.)...
The rapidly and constantly evolving coronavirus, SARS-CoV-2, imposes a great threat to human health causing severe lung disease significant mortality. Cytoplasmic stress granules (SGs) exert anti-viral activities due their involvement in translation inhibition innate immune signaling. SARS-CoV-2 sequesters important SG nucleator proteins impairs formation, thus evading the host response for efficient viral replication. However, significance of SGs COVID-19 infection remains elusive. In this...
Protein aggregation and amyloidogenesis have been associated with several neurodegenerative disorders like Alzheimer's, Parkinson's etc. Unfortunately, there are still no proper drugs effective treatment available. Due to the unique properties of noble metallic nanoparticles, they used in diverse fields biomedicine drug designing, delivery, tumour targeting, bio-sensing, tissue engineering Small-sized silver nanoparticles reported anti-biotic, anti-cancer anti-viral activities apart from...
Cardiovascular damage induced by anticancer therapy has become the main health problem after tumor elimination. Venetoclax (VTX) is a promising novel agent that been proven to have high efficacy in multiple hematological diseases, especially acute myeloid leukemia (AML) and chronic lymphocytic (CLL). Considering its mechanism of action, possibility VTX may cause cardiotoxicity cannot be ruled out. Therefore, this study was designed investigate toxic effect on heart. Male Sprague-Dawley rats...