A5024062225- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- Medication Adherence and Compliance
- Natural Antidiabetic Agents Studies
- vaccines and immunoinformatics approaches
- Economic and Financial Impacts of Cancer
- Drug Transport and Resistance Mechanisms
- Curcumin's Biomedical Applications
- Pharmaceutical Economics and Policy
- Pharmacological Effects of Natural Compounds
- Research on Leishmaniasis Studies
- Traditional Chinese Medicine Analysis
- SARS-CoV-2 and COVID-19 Research
- Drug Solubulity and Delivery Systems
- Medicinal Plants and Neuroprotection
- Cancer, Lipids, and Metabolism
- Diverse Scientific Research Studies
- Nuclear Receptors and Signaling
- Growth Hormone and Insulin-like Growth Factors
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Chromatography in Natural Products
- Ferroptosis and cancer prognosis
- Metabolism, Diabetes, and Cancer
- Analytical Methods in Pharmaceuticals
University of Dhaka
2020-2025
Transporter associated with antigen processing 1 (TAP1) is a transporter protein that represent tumor in the MHC I or HLA complex. Any defect TAP1 gene resulting inadequate tracking. influences multidrug resistance (MDR) human cancer cell lines and hinders treatment during chemotherapeutic. The association of progression remains mostly unknown further study relation need to conduct. Thus, has designed analyze between by computationally. expression pattern determined using ONCOMINE, GENT2,...
Background: Diabetic wounds are a significant clinical challenge due to impaired healing processes often exacerbated by elevated matrix metalloproteinases (MMPs). Cinnamomum zeylanicum , known for its anti-inflammatory and antioxidant properties, has shown potential in promoting wound healing. This study investigates the molecular docking experimental validation of 's effects on diabetic healing, focusing interaction with metalloproteinases-8 (MMP-8) 9 (MMP-9). Methods: Molecular studies...
Transporter associated with antigen processing 1 (TAP1) gene codes for a transporter protein, which is responsible tumor presentation in the MHC I or HLA complex. A defect results an inadequate tracking. TAP1 may also influence multi drug resistance, extreme threat providing treatment by drugs are chemotherapeutic. The of was analyzed bioinformatically. It gave us prognostic data as confirmation whether it should be used biomarker. expression level and pattern analysis were conducted using...
The most frequently prescribed first-line treatment for type II diabetes mellitus is metformin. Recent reports asserted that this medication can also shield users from cancer. Metformin induces cell cycle arrest in cancer cells. However, the exact mechanism by which occurs system yet to be elucidated. Here, we investigated impact of metformin on cells utilizing transforming growth factor (TGF)-beta pathway. TGF-ß pathway has significant effect progression and growth. In order gain an insight...
With the increasing rate of people being affected by cancer in Bangladesh, disease has become a national concern. Anti-cancer drugs play significant and crucial role treatment regimen. Inadequate access to essential anti-cancer medicines may impose serious public health problems Bangladesh. The present study gives an insight on availability eleven WHO enlisted anticancer that are commonly prescribed for top five prevalent types (Breast, Oesophagus, Lung, Cervix, Lips Oral cavity) Expert...
Metformin, taken by nearly 120 million people across the world as a treatment for type 2 diabetes, has relatively short plasma half-life and low absolute bioavailability. In this study, physicochemical pharmacokinetics properties of metformin have been thoroughly assayed using ADMETLab, SwissADME, SmartCYP, LigandScout web-servers software to evaluate effectiveness its formulation controlledrelease matrix tablets. The objective present work was develop an oral controlled-release (CR) tablet,...
In Bangladesh, the incidence and death rate of patients suffering from dengue infection are escalating. To date, there is no effective antiviral against virus. Treatment regimen mostly includes symptomatic management disease. this study, we performed molecular docking with 36 phytochemicals extracted Bangladeshi medicinal plants namely Averrhoa carambola L., Curcuma longa Nyctanthes arbor-tristis L. Zingiber officinale virus non-structural protein 2/non-structural 3 (NS2/NS3) chimera. The...
Minichromosome Maintenance Complex Component-7 (MCM7) plays a significant role in DNA replication. A comprehensive search of oncogenic databases (UALCAN and KMplot) revealed overexpression or upregulation MCM7 number cancers (including top prevalent cancer types worldwide). Thus, identification novel compounds that can decrease expression level act as therapeutic strategy against the malignancies which is upregulated. In pursuit this, computational drug discovery methodology was adopted to...