A5080182686- Synthesis and biological activity
- Synthesis and Biological Activity
- Synthesis and Reactions of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Bioactive Compounds and Antitumor Agents
- Synthesis of heterocyclic compounds
- Crystal structures of chemical compounds
- X-ray Diffraction in Crystallography
- Advanced Breast Cancer Therapies
- Paraquat toxicity studies and treatments
- Synthesis and Catalytic Reactions
- Cancer Mechanisms and Therapy
- Crystallization and Solubility Studies
- Toxoplasma gondii Research Studies
- Cancer therapeutics and mechanisms
- Chemical synthesis and pharmacological studies
- Click Chemistry and Applications
- Ginger and Zingiberaceae research
- Computational Drug Discovery Methods
New Valley University
2021-2025
South Valley University
2021-2025
Nile Valley University
2021-2024
Assiut University
2021-2024
National Research Centre
2023
King Khaled Hospital
2021
Abstract In this study, we synthesized new 5,6,7,8-tetrahydroisoquinolines and 6,7,8,9-tetrahydrothieno[2,3- c ]isoquinolines based on 4-( N , -dimethylamino)phenyl moiety as expected anticancer and/or antioxidant agents. The structure of all compounds were confirmed by spectral date (FT-IR, 1 H NMR, 13 C NMR) elemental analysis. We evaluated the activity these toward two cell lines: A459 line (lung cancer cells) MCF7 (breast cells). All tested showed moderate to strong anti-cancer towards...
Abstract In this study, new tetrahydroisoquinoline compounds were synthesized by reaction of 7-Acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8- (3-nitrophenyl or 4-nitrophenyl)-5,6,7,8-tetrahydrosoquinoline-3(2 H )-thiones with methyl iodide, chloro acetonitrile, ethyl chloroacetate to produce 3–5 and reacted N -arylchloroacetamides reagents gave tetrahydroisoquinolin-3-ylthio) acetamides 6a – c , 8a b which can cyclized 6,7,8,9-tetrahydrothieno[2,3-c]Isoquinoline-2-carboxamides 7a c, 9a . Also...
ABSTRACT In this work, we synthesized new 5, 6, 7, 8‐tetrahydroisoquinolines and 8, 9‐tetrahydrothieno[2, 3‐ c ]isoquinolines derivatives, the structures of these compounds were confirmed with different spectroscopic techniques. Furthermore, anticancer activities assessed against eight tumor cell lines one normal human skin fibroblast line ( HSF ). Subsequently, IC 50 values determined for two specific cancer lines. Compound 3 exhibited most potent antiproliferative activity HEPG2 line,...
Regioselective cyclocondensation of 2,4-diacetyl-5-hydroxy-5-methyl-3-(3-nitrophenyl/4-nitrophenyl)cyclohexanones 1a,b with cyanothioacetamide afforded the corresponding 7-acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8-(3- and -4-nitrophenyl)-5,6,7,8-tetrahydrosoquinoline-3(2H)-thiones 2a,b. Reaction compounds 2a,b ethyl iodide, 2-chloroacetamide (4a), or its N-aryl derivatives 4b-e in presence sodium acetate trihydrate gave 3-ethylthio-5,6,7,8-tetrahydroisoquinoline 3...
Background:Toxoplasma gondii (T. gondii) is an opportunistic parasite that causes serious diseases in humans, particularly immunocompromised individuals and pregnant women. To date, there are limited numbers of therapeutics for chronic toxoplasmosis which necessitate the discovery effective safe therapeutics. In present study, we aimed to evaluate antitoxoplasmosis potential ginger extract mice with experimentally induced toxoplasmosis. Results: Treatment significantly reduced cysts count...
The title molecule, C 29 H N 3 O 4 S, adopts a conformation with the two phenyl substituents disposed on opposite sides of mean plane isoquinoline unit. In crystal, corrugated layers molecules are formed by N—H...O, C—H...N and C—H...S hydrogen bonds together C—H...π(ring) interactions. These connected C—H...O contacts. Hirshfeld surface analysis crystal structure indicates that most important contributions for packing from H...H (45.2%), C...H/H...C (20.2%), O...H/H...O (15.8%) N...H/H...N (11.0%)
<title>Abstract</title> In this work 7-Acetyl-4-cyano-1, 6-dimethyl-6-hydroxy-8-(2-nitrophenyl)-5,6,7,8-tetrahydrosoquinoline-3(2<italic>H</italic>)-thione compound <bold>2</bold> was synthesized and used as starting materials. Subsequently, Compounds <bold>3–7</bold> were produced through its reaction with ethyl iodide, chloroacetate, chloroacetonitrile, chloroacetaldehyde. Additionally, 2-chloroacetamide heated in ethanol sodium acetate trihydrate present, resulting the formation of...
<title>Abstract</title> In this work 7-Acetyl-4-cyano-1, 6-dimethyl-6-hydroxy-8-(2-nitrophenyl)-5,6,7,8-tetrahydrosoquinoline-3(2<italic>H</italic>)-thione compound <bold>2</bold> was synthesized and used as starting materials. Subsequently, Compounds <bold>3–7</bold> were produced through its reaction with ethyl iodide, chloroacetate, chloroacetonitrile, chloroacetaldehyde. Additionally, 2-chloroacetamide heated in ethanol sodium acetate trihydrate present, resulting the formation of...
<title>Abstract</title> In this study, 7-Acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8- (3-nitrophenyl or 4-nitrophenyl)-5,6,7,8-tetrahydrosoquinoline-3(2<italic>H</italic>)-thiones <bold>2a-b </bold>were synthesized<bold> </bold>and used as starting materials. Thus, compounds reacted with methyl iodide, ethyl chloroacetate, by heating in ethanol the presence of sodium acetate trihydrate to give 3-substituted methylthio-5,6,7,8-tetrahydroisoquinoline-4-carbonitriles <bold>3, 4,...
<title>Abstract</title> In this study, new tetrahydrosoquinoline compounds were synthesized by reacted with methyl iodide, chloro acetonitrile, ethyl chloroacetate, N-arylchloroacetamides N-and (benzthiazol-2-yl)-2-chloroacetamide reagents to gave tetrahydroiso-quinolin-3-ylthio) acetamides (<bold>5a-c</bold>) which can cyclized (<bold>6a-c)</bold> in excellent yields. The structures of all newly characterized elemental and spectral analyses. Also, most the evaluated for their anticancer...
Abstract Regioselective cyclocondensation of 2,4-diacetyl-5-hydroxy-5-methyl-3-(3-nitrophenyl/4-nitrophenyl)cyclohexanones 1a,b with cyanothioacetamide fforded the corresponiing 7-acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8-(3-nitrophenyl/4-nitrophenyl)-5,6,7,8-tetrahydro-soquinoline-3(2 H )-thiones 2a,b in 93-96%. Reaction compounds ethyl iodide, 2-chloroacetamide or N -(naphthalen-1-yl)-2-chloroacetamide ( 5 ) presence sodium acetate gave corresponding p(5,6,7,8-tetrahydroisoquinolin-3-yl)thio...
Abstract In this study, we synthesized new 5,6,7,8-tetrahydroisoquinolines and 6,7,8,9-tetrahydrothieno[2,3- c ]isoquinolines based on 4-( N , -dimethylamino)phenyl moiety as expected anticancer and/or antioxidant agents. The structures of all compounds were confirmed by spectroscopic data elemental analyses. We evaluated the activity these towards two cell lines: A459 (lung cancer line) MCF7 (breast line). All tested showed moderate to strong anti-cancer lines. Compound 7e exhibited...