A5100661647- Crystal structures of chemical compounds
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Synthesis and Characterization of Heterocyclic Compounds
- Metal complexes synthesis and properties
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis of Organic Compounds
- Synthesis of heterocyclic compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis and Reactions of Organic Compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Biological Evaluation
- Synthesis and Reactivity of Heterocycles
- Organometallic Compounds Synthesis and Characterization
- Fluorine in Organic Chemistry
- Synthesis of β-Lactam Compounds
- Magnetism in coordination complexes
- Synthesis and Catalytic Reactions
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Multicomponent Synthesis of Heterocycles
- Coordination Chemistry and Organometallics
- Quinazolinone synthesis and applications
Erciyes University
2016-2025
Graz University of Technology
2019
University of Aberdeen
2019
University of Toronto
2019
Kocaeli Üniversitesi
2018
Minia University
2016
Dicle University
2014
Inonu University
2011
Kastamonu University
2006-2010
Ondokuz Mayıs University
2006-2010
Many people around the world suffer from malaria, especially in tropical or subtropical regions. While malaria medications have shown success treating there is still a problem with resistance to these drugs. Herein, we designed and synthesized some structurally novel benzotriazole-β-lactams using 2-(1H-benzo[d][1,2,3]triazol-1-yl)acetic acid as key intermediate. To synthesize target molecules, ketene-imine cycloaddition reaction was employed. First, The of 1H-benzo[d][1,2,3]triazole...
Novel benzimidazolium salts having N-benzyl or N-(4-substitutedbenzyl) groups were synthesized and their microwave-promoted catalytic activity for the Suzuki--Miyaura cross-coupling reaction determined using in situ formed palladium(0) nanoparticles (PdNPs) from a system consisting of Pd(OAc)_2/K2CO_3 DMF/H_2O. PdNPs characterized by X-ray diffraction (XRD) pattern particle size generated Pd(111) plane was to be diameter 19.6 nm Debye--Scherrer equation. Moreover, yield reactions with aryl...
A series of unsymmetrically substituted N ‐heterocyclic carbene (NHC) precursors ( 1a , 1b 1c 1d 1e ) were synthesized from the reaction ‐phenylbenzimidazole with various alkyl halides. These compounds used to synthesize NHC–silver(I) complexes 2a 2b 2c 2d 2e ). The five new 1‐phenyl‐3‐alkylbenzimidazolium salts and their NHC–silver characterized by 1 H NMR, 13 C NMR FT‐IR spectroscopic methods elemental analysis techniques. Also, two single‐crystal X‐ray crystallography, which confirmed...
The title compound, C 11 H 6 N 3 SSe + ·Cl − , produced by the reaction between 3,4-dicyanothiophene and 2-pyridylselenyl chloride was isolated as a salt that crystallizes in triclinic space group P 1 . Notable features include strong chalcogen interactions (Se...Cl Se...S), revealed through Hirshfeld surface analysis, which also highlights significant contributions from N...H/H...N, C...H/H...C H...H contacts crystal packing. Supramolecular were further analysed using density functional...
Molecules of the title compounds, methyl ( Z )-2-(4-bromophenyl)-2-[2-(4-methylphenyl)hydrazin-1-ylidene]acetate, C 16 H 15 BrN 2 O , 1 ), )-2-(4-bromophenyl)-2-[2-(3,5-dimethylphenyl)hydrazin-1-ylidene]acetate, 17 )-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]-2-(3-nitrophenyl)acetate, N 3 5 and )-2-[2-(4-bromophenyl)hydrazin-1-ylidene]-2-(4-chlorophenyl)acetate, 12 BrClN adopt a configuration with respect to central C=N bond, while E )-2-(4-chlorophenyl)-2-(2-phenylhydrazin-1-ylidene)acetate,...
In the context of research into new synthetic possibilities under conditions catalytic olefination reaction (COR), based on (E)‐2‐((2‐(p‐tolyl)hydrazineylidene)methyl)phenol (an N‐substituted phenylhydrazone), (E)‐2‐(2,2‐dichloro‐1‐(phenyldiazenyl)vinyl)phenol (dichlorovinyldiazene) was synthesized. This compound undergoes a one‐step conversion with ethyl alcohol to yield corresponding (Z)‐3‐(2‐(p‐tolyl)hydrazineylidene)benzofuran‐2(3H)‐one.To assess its interactions biological targets,...
We report herein the design and synthesis of 17 new spiroheterocycles 10-26, on basis two hypothetical pharmacophore structures designed to interact with both Mycobacterium tuberculosis bacteria HIV-1 virus.The in vitro biological evaluation these compounds allowed us point out seven potential non-nucleoside hits, MIC values range 6.25 µg/mL anti-HIV-1 inhibitors .
A mixture of benzimidazole salts (2–7), Pd(OAc)2 and K2CO3 in DMF–H2O catalyzes the Suzuki–Miyaura cross-coupling reactions promoted by microwave irradiation resulting high yield within a short time. In particular, with aryl bromides was found to be nearly quantitative. The synthesized (2–7) were identified 1H-13C, NMR, IR spectroscopic methods microanalysis. molecular structure 1 determined X-ray crystallography. antibacterial antifungal activities novel derivatives (1–7) also tested...
ABSTRACT: The synthesis of a new series flurbiprofen hydrazide-hydrazones using microwave assisted reactions is described. Substituted aldehydes were condensed with hydrazide by irradiation to corresponding hydrazones. Synthesis N’-[(4-bromothiophen-2-yl)methylidene]-2-(2-fluorobiphenyl-4-yl) propanehydrazide (3o) employing process resulted in higher yields, faster time and less chemical waste compared traditional techniques. (2-fluorobiphenyl-4-yl)-N’- (phenylmethylidene)propanehydrazide...
In the title compound, C 16 H 15 N 5 , 1,4-dihydropyridine ring has a shallow boat conformation, while 1,3-diazinane adopts an envelope conformation. crystal, pairwise N—H...N hydrogen bonds generate centrosymmetric dimers featuring R 2 (12) motifs and C—H...N contacts connect these to form double layers lying parallel (001). Weak C—H...π N—H...π interactions help consolidate van der Waals occur between layers. A Hirshfeld surface analysis indicates that most significant contributions...
In the title compound, C16H11BrN6O·2C2H6OS, 1,2,3,7-tetra-hydro-imid-azo[1,2-a]pyridine ring system and oxindole moiety are both nearly planar [maximum deviations = 0.042 (2) 0.115 Å, respectively] their planes form a dihedral angle of 86.04 (5)° with each other. Inter-molecular N-H⋯O, C-H⋯O C-H⋯N hydrogen bonds link mol-ecules in crystal through O atoms solvent mol-ecules, generating three-dimensional network. A Hirshfeld surface analysis was performed to further analyse inter-molecular...
In the title mol-ecule, C
In the title compound, C 14 H 8 Cl 3 FN 2 , planes of 4-fluorophenyl ring and 4-chlorophenyl make a dihedral angle 56.13 (13)°. crystal, molecules are stacked in column along axis via weak C—H...Cl hydrogen bond face-to-face π–π stacking interactions [centroid–centroid distances = 3.8615 (18) 3.8619 Å]. The crystal packing is further stabilized by short Cl...Cl contacts. Hirshfeld surface analysis structure indicates that most important contributions for from Cl...H/H...Cl (31.2%), H...H...
A series of nine polypyridyl-ruthenium (II) complexes (N-ligands = 2,2′-bipyridines; 2,2′-6′,2′-terpyridines, di-alkyloxy-2,2′-6,2-bipyridine-3,3′-di-carboxylates), were tested against Mycobacterium tuberculosis (MBT). The complex (11) showed remarkable activity MBT as compared to other complexes, (1–10). aquo ligand (11), opposed chloro and acetonitrile derivatives, appears play a key role in the antitubercular potency this new class metal-based compounds.
In the title mol-ecule, C(16)H(12)F(2)N(2)O, pyrazole ring adopts a slight envelope conformation with methyl-ene C atom deviating by 0.114 (3) Å from mean plane of other four atoms [maximum deviation = 0.021 Å]. The dihedral angles between essentially planar and fluoro-substituted benzene rings are 2.6 (2) 82.2 (2)°. angle two is 83.7 crystal packing stabilized weak inter-molecular C-H⋯O hydrogen bonds.
In the title compound, C25H20O2, central cyclo-hexenone ring adopts an envelope conformation. The mean plane of makes dihedral angles 87.66 (11) and 23.76 (12)°, respectively, with two attached phenyl rings, while it is inclined by 69.55 (11)° to benzoyl group. crystal, mol-ecules are linked C-H⋯O C-H⋯π inter-actions, forming a three-dimensional network.
In the molecular structure of title compound, C 16 H 13 Cl 2 N 5 , 1,4-dihydropyridine ring 1,3,4,8-tetrahydro-2 -pyrido[1,2- a ]pyrimidine system adopts screw-boat conformation, while 1,3-diazinane is puckered. crystal, intermolecular N—H...N and C—H...N hydrogen bonds form sheets parallel to (110) (\overline{1}10) planes, crossing each other. Adjacent molecules are further linked by C—H...π interactions, which zigzag chains propagating [100]. A Hirshfeld surface analysis indicates that...