2-Phenylethanol is an aromatic compound commonly used in the food, cosmetic, and pharmaceutical industries. Due to increasing demand for natural products by consumers, production of this flavor microbial fermentation gaining interest, as a sustainable alternative chemical synthesis or expensive plant extraction, both processes relying on use fossil resources. However, drawback process high toxicity 2-phenylethanol producing microorganism. The aim study was obtain 2-phenylethanol-resistant...

Novel benzimidazolium salts having N-benzyl or N-(4-substitutedbenzyl) groups were synthesized and their microwave-promoted catalytic activity for the Suzuki--Miyaura cross-coupling reaction determined using in situ formed palladium(0) nanoparticles (PdNPs) from a system consisting of Pd(OAc)_2/K2CO_3 DMF/H_2O. PdNPs characterized by X-ray diffraction (XRD) pattern particle size generated Pd(111) plane was to be diameter 19.6 nm Debye--Scherrer equation. Moreover, yield reactions with aryl...

Increased exposure to nickel compounds and alloys due industrial development has resulted in pollution many pathological effects on human health. However, there is very limited information about response, transport, tolerance eukaryotes. To investigate resistance the model eukaryote Saccharomyces cerevisiae, evolutionary engineering by batch selection under gradually increasing stress levels was performed. Nickel hyper-resistant mutants that could resist up 5.3 mM NiCl2 , a lethal level for...

A mixture of benzimidazole salts (2–7), Pd(OAc)2 and K2CO3 in DMF–H2O catalyzes the Suzuki–Miyaura cross-coupling reactions promoted by microwave irradiation resulting high yield within a short time. In particular, with aryl bromides was found to be nearly quantitative. The synthesized (2–7) were identified 1H-13C, NMR, IR spectroscopic methods microanalysis. molecular structure 1 determined X-ray crystallography. antibacterial antifungal activities novel derivatives (1–7) also tested...

Iron plays an essential role in all organisms and is involved the structure of many biomolecules. It also regulates Fenton reaction where highly reactive hydroxyl radicals occur. important for microbial biodiversity, health nutrition. Excessive iron levels can cause oxidative damage cells. Saccharomycescerevisiae evolved mechanisms to regulate its levels. To study stress resistance S. cerevisiae, evolutionary engineering was employed. The stress-resistant mutant "M8FE" analysed...

Cobalt is an important metal ion with magnetic properties that widely used for several industrial applications. Overexposure to cobalt ions can be highly toxic the organisms because they usually overwhelm endogenous physiological system maintains their homeostasis causing (geno)toxic effects. To gain insight into mechanism of toxicity, we characterized at molecular and genetic levels a resistant CI25E Saccharomyces cerevisiae strain previously isolated by in vivo evolutionary engineering...

Abstract A mixture of bis‐benzimidazole salts ( 1–7 ), Pd(OAc) 2 and K CO 3 in DMF H O catalyzes, high yield, the Suzuki Heck cross‐coupling reactions assisted by microwave irradiation a short time. In particular, yields with aryl bromides were found to be nearly quantative. The synthesized 1 – 7 ) identified H 13 C NMR, IR spectroscopic methods micro analysis. Copyright © 2010 John Wiley & Sons, Ltd.

Some bis-benzimidazoles derivatives bearing allyl, crotyl, cinammyl, furfuryl, and thenyl groups were synthesized their in vitro antimicrobial activity determined against gram-positive gram-negative bacteria, fungi by disk-diffusion method. The structures of all new compounds identified ^1H-NMR, ^{13}C-NMR, FT-IR spectroscopic techniques elemental analysis. All the this work examined for activities (Staphylococcus aureus Bacillus megaterium) bacteria (Klebsiella pneumoniae Escherichia coli),...

A number of novel benzimidazolium salts having aryl substituents such as N-phenyl, 4-chlorophenyl and various alkyl were synthesized. Their microwave-assisted catalytic activities evaluated in Heck-Mizoroki Suzuki-Miyaura cross-coupling reactions using a system consisting Pd(OAc)2/K2CO3 DMF/H2O under mild reaction conditions with consistent high yields, except those 2-bromopyridine.

A number of novel benzimidazole derivatives 1-4 were synthesized and the catalytic activity these compounds in a system consisting benzimidazolium salt/Pd(OAc)2/K2CO3 investigated Suzuki-Miyaura Ullmann type homocoupling reactions under microwave irradiation. We obtained both cross coupling products pyridine some side such as dimethylaminopyridine unsubstituted pyridine.

Abstract A mixture of novel benzimidazole salts (2a–f), Pd(OAc) 2 and K CO 3 in DMFH O catalyzes, high yield, the Heck cross‐coupling reaction assisted by microwave irradiation a short time. All synthesized derivatives were characterized elemental analysis NMR spectroscopy. In addition, molecular structure 2a was determined X‐ray crystallography. Copyright © 2011 John Wiley & Sons, Ltd.

The Co(II), Zn(II), Ni(II), Cu(II), and Fe(II) complexes of 1-phenylbenzimidazole were synthesized characterized by NMR elemental analyses. crystal structures dichlorobis(1-phenyl-1 H-benzimidazole-κN3 )cobalt(II) )zinc(II) have been determined single-crystal X-ray diffraction.

Five novel benzimidazole salts (1-5) having N-phthalimidoethyl and 4-substituted benzyl were synthesized identified by $^{1}$H NMR, $^{13}$C IR spectroscopic methods microanalysis. A mixture of the (1-5), Pd(OAc)$_{2}$, K$_{2}$CO$_{3}$ in DMF-H$_{2}$O catalyzed, high yield, Suzuki-Miyaura Heck-Mizoroki cross-coupling reactions assisted microwave irradiation 5 min. The Cs$_{2}$CO$_{3}$, PEG, Cu nanoparticles Sonogashira coupling reaction promoted 10 same TBAB moderate or low Buchwald-Hartwig...

GRAPHICAL ABSTRACTSynthesis and characterization of novel phosphoramidates containing benzimidazole moietyAll authorsÜlkü Yılmaz & Hasan Küçükbayhttps://doi.org/10.1080/10426507.2015.1067209Published online:15 January 2016

Abstract A series of 5(6)‐substituted benzimidazole ligand‐zinc(II) and cobalt(II) complexes were synthesized characterized by 1 H, 13 C NMR, IR, CHN analysis techniques. In vitro, anticancer antimicrobial activities ligand evaluated. The cytotoxic compounds investigated against the human lung adenocarcinoma (A549) cell lines healthy bronchial epithelium (BEAS2B) cells. Compounds , 6 8 observed to exhibit higher activity than others at 72nd hour. Also, showed varying degrees microorganisms...

The Co(II), Fe(II), and Zn(II) complexes of 1-(3-phenyl)propylbenzimidazole (PPBI), 5-nitro-1-(3-phenyl) propylbenzimidazole (PPNBI), 1-[2-(4-morpholinyl)ethyl]benzimidazole (MEBI), 1-[2-(1-piperidinyl)ethyl]benzimidazole (PEBI), 5-nitro-1-[2-(1-piperidinyl)ethyl]benzimidazole (PENBI) were synthesized characterized by ^1H NMR, ^{13}C elemental analyses. magnitudes the magnetic moments for paramagnetic between 4.07 5.11 B.M. Moreover, crystal structure...

A number of benzimidazole derivatives (1-8) were synthesized and the catalytic activity these compounds in a system including Pd(OAc)_2 K_2CO_3 DMF-H_2O was evaluated Heck-Mizoroki Suzuki-Miyaura cross-coupling reactions aryl iodides, bromides, chlorides with styrene arylboronic acids under microwave irradiation aerobic conditions. The yields both cross coupling iodides bromides nearly quantitative. 1-substituted (1) salts (2-8) identified by ^1H- ^{13}C-NMR IR spectroscopic methods, micro...

In this work, 1,4-bis(3-isopropylbenzimidazolidine-2-ylidene-1-yl)butane (1) and 1,4-bis(3,5(6)-dimethylbenzimidazolidine-2-ylidene-1-yl)butane (2) were reacted with oxygen, sulfur, selenium, tellurium, phenyl isothiocyanate carbon disulfur. New zwitterionic compounds (9-12) cyclic urea derivatives of benzimidazole as one (3), thione (4,6), selenone (5,7), tellurone (8) synthesised from electron-rich olefins. The chemical structure novel determined by 1H NMR, 13C FTIR spectroscopic...