In the present work, we describe extraction of a natural product namely 1,4,9,9-tetramethyloctahydro-4,7-(epoxymethano)azulen-5(1H)-one, and its structure was confirmed by single crystal X-ray diffraction analysis. The conformations 5-, 6-, 7-membered rings in title compound, C15H24O2, have been probed Cremer-Pople puckering C—H···O hydrogen bonds generate chains that stretch along c-axis direction. Hirshfeld surface analysis method used to stabilize packing compound. Accompanied...

The food industry consumes large amounts of water although there is an increasing demand for and a rapid decrease in the level natural resources. Wastewater resulting from industries needs to be assessed their compliance standards. In this study, wastewater treatment steps were investigated accurate assessment loading by analyzing parameters concentration compounds present effluents. results revealed that treated as follow, electrical conductivity 2931 μs/cm, total suspended solids 100 mg/L,...

Quality and safety of drugs are essential for effective therapeutic performance. Impurities can compromise the quality drugs, they arise during various stages development, production, storage even transportation process. Therefore, detecting measuring number impurities with high accuracy in is necessary to ensure reduce risks associated taking them. Detecting require advanced analytical techniques. The review highpoints a variety chemistry techniques include spectrophotometric...

A new series of Schiff bases derived from pyrazole-thiocarbohydrazide, namely (4a-d), were well-synthesized. The synthesis is carried out using monothiocarbohydrazone derivative (3), which was prepared via coupling 5-chloro-pyrazole-4-carbaldehyde (1) with thiocarbohydrazide (2) in absolute ethanol that contains a catalytic quantity acetic acid. structures newly synthesized compounds fully clarified by various spectroscopic analyses (FT-IR, 1H-NMR, 13C-NMR, and mass spectra) elemental...

This manuscript reports the preparation and toxicological efficacy testing of nine oxoimidazolidine cyanoguanidine compounds (3a, 3b, 3c, 3d, 3e, 3f, 3g 4a, 4b) against cowpea aphid, Aphis craccivora Koch. Bioefficacy data revealed that tested exhibited a range activities these insects, with compound 3b being most toxic 4a least effective. The LC50 value was 1.72 ppm for adults 0.02 nymphs while 72.51 18.02 nymphs. also presents structure-activity relationships compounds. These results...

Quinazoline compounds have gained significant attention in the fields of agriculture and chemistry due to their diverse activities. In this study, we focused on a series quinazoline derivatives (4a–l). The objectives involved multiple aspects, including preparation, evaluation agricultural bioactivity against maize aphid (Rhopalosiphum maidis), estimation structure–activity relationships (SAR), conducting molecular docking analysis. results bioactivities revealed that compound (4b) possesses...

Biologically active organic compounds continue to attract great interest due the wide variety of interesting applications observed for these compounds. This review results from literature survey containing that are used as insect growth regulators with a focus on their mode action and some synthetic routes.

Oxygen-containing heterocycles are largely distributed in natural and synthetic compounds. Coumarins among the most famous which possess one oxygen atom their rings. classified as multifunctional scaffold used anti-oxidant reagents, anti-inflammatory, anti-microbial, anti-fungal, anti-HIV active, analgesic, anti-histaminic, insecticides, dyes, herbicides, sensitizers, perfumes, cosmetics food additives. Due to diverse applications industrial pharmaceutical fields, many chemists have given...

In developing countries, it still suffers from endless problems regarding wastewater treatment and the problem of choosing appropriate system due to lack proper technology weak economy. This study highlights maturity oxidation pond (stabilization) small communities as an effective, low-cost simple post-treatment technique for treating before discharging into aquatic ecosystem. The Rashid plant was cited a in city Rashid-ElBeheira Governorate - Egypt model applying this wastewater. work also...

This work includes the synthesis of ten heterocyclic compounds (3a-i and 4) containing pyrimidine moiety incorporated in their structures. Structure characterizations these were performed by using elemental spectroscopic analyses. Their toxicity as potential insecticidal agents against adults nymphs cowpea Aphid, Aphis craccivora Koch was evaluated. The results this toxicological activity test revealed that a reasonable number possess excellent aphids such (3d), (3c), (3b) with LC50 values...

Pyrimidine compounds continue to attract great interest in the field of organic synthesis due their various chemical and biological applications observed, especially recent times. As a result, this review covering some periods from 1957 2021 has been prepared discuss structural pathways these as well interactions applications.

Due to the complicated problems coming from excessive applications of insecticides, searching for safe substitutes these insecticides has become a necessity. Thus, insect growth regulators are candidates be used in such concern. Comparative studies effects three compounds, 2-benzoyl-N-phenylhydrazine-1-carbothioamide (1), 2-(cyanoacetyl)-N-phenylhydrazine-1-carboxamide (2) and N-(2-(2-cyanoacetyl)hydrazinecarbonothioyl)furan-2-carboxamide (3) (an regulator inhibiting chitin synthesis), were...

Herbicides used on a regular basis could endanger non-target species like earthworms. The aim of this work was to test the toxic effect atrazine and metribuzin Aporrectodea caliginosa by filter paper contact soil mixing techniques. Atrazine had highest intrinsic toxicity earthworms, with LC50 0.026 µg mL-1 after 72 hr treatment. While 0.063 test. reduced from 11.121 3.118 164.824 19.113 μg g soil-1 in clay soil, 32.221 17.33 324.141 41.028 (1:1) 41.234 30.804 462.255 70.902 sandy loam 5 10...

Thiazolopyrimidnes are considered one of the most interesting classes in heterocyclic chemistry due to their pharmaceutical importance. Herein, we report synthesis some new compounds containing thiazolopyrimidine starting from compound (1) which was previously prepared literature. The allowed react with different alkylating agents such as chloroacetone, chloroacetyl chloride, and phenacyl bromide afford derivatives (2-4). Compound (5), benzylidene derivative, obtained by reaction (2)...

In the title mol-ecule, C

2-Indolinone nucleus is considered one of a promising heterocyclic core in medicinal chemistry that showed numerous range activity among which antimicrobial, antioxidant, antiviral, antitubercular and anticancer activities. Cancer targeting still an issue so there need for developing new agents inhibit cancer growth without or low effect on normal body cells. Some derivatives indolin-2-one are known to be critical structure some inhibitors receptor tyrosine kinases (RTKs); target therapy,...

An isocratic HPLC technique was exploited and validated for the quick simultaneous separation measurement of cefotaxime paracetamol in vials dosage forms, with a total analysis time 3 minutes. The process carried out on Thermo Scientific® Venusil XBPC18 (L) (5µm, 4.6x250 mm) using mobile phase ACN: distilled water (70:30, v/v) at ambient temperature. flow rate used experiment 1 mL/min, highest level absorption determined by high-performance liquid chromatography photodiode array detection...

A series of furan derivatives tebufenozide analogues comprising five compounds (2, 3, 4, 5, and 6) have been designed synthesized via reaction N'-phenylfuran-2-carbohydrazide (1) with different acid chlorides. The structures the were identified by elemental analyses spectroscopic data. active center (mimic) change tertiary butylhydrazine phenylhydrazine. Studying effect this on toxicological activity against Spodoptera littoralis larvae was performed for three ones. Toxicological data showed...

Pyrazolones are a class of heterocyclic compounds that contain pyrazole ring fused to ketone group. Recent scientific research has focused extensively on the potential anti-inflammatory properties pyrazolone due their diverse pharmacological effects in alleviating inflammation and reducing fever. This motivated us focus preparation these derivatives simple eco-friendly manner. A convenient new green methodology was modified for 1-phenyl-3,5-pyrazolidinedione by sonicated MCR diethyl...

Increasing the yield and nutritional value of faba beans is one main objectives common bean cultivar improvement programs due to its contribution terminate protein deficiency malnutrition in developing countries raising income level smallholder farmers. In this study, technological quality seeds from twenty-four genotypes were evaluated (twenty germplasm four improved cultivars (Misr 1, Giza 429, 716, 843). The results showed a significant diversity Egyptian their traits compared control...

In this paper, 3-cyano-4-(p-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinoline-2(1H)-thione (2) was prepared and reacted with methyl iodide to give the corresponding 2-methylthio derivative 3. Fusion of compound 2 or 3 hydrazine hydrate produced aminopyrazolotetrahydroquinoline-5-hydrazone 4. Reaction both compounds phenylhydrazine thiosemicarbazide led formation condensation products 6a,b 9a,b respectively.Reaction cyanoquinolinethione some α-halocarbonyl namely; ethyl chloroacetate,...