A5079230134- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Crystallization and Solubility Studies
- 3D Printing in Biomedical Research
- Pharmaceutical studies and practices
- Crystallography and molecular interactions
- Analytical Methods in Pharmaceuticals
- Hydrogels: synthesis, properties, applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Computational Drug Discovery Methods
- Antibiotics Pharmacokinetics and Efficacy
- Probiotics and Fermented Foods
- Pharmacological Effects of Natural Compounds
- Analytical Chemistry and Chromatography
- Dermatology and Skin Diseases
- Additive Manufacturing and 3D Printing Technologies
- Nanoparticle-Based Drug Delivery
- Microfluidic and Capillary Electrophoresis Applications
- Polysaccharides Composition and Applications
- Gastrointestinal motility and disorders
- Advanced Chemical Sensor Technologies
- Food Industry and Aquatic Biology
- Microbial Inactivation Methods
- Chemotherapy-related skin toxicity
University of Balochistan
2024
University of Okara
2024
University of the Punjab
2014-2023
Tamil Nadu Dr. M.G.R. Medical University
2021
Bahauddin Zakariya University
2021
De Montfort University
2015-2018
Purpose: To develop and evaluate nanosponge (NS) based sustained release formulations of naproxen (NAP) ibuprofen (IBU).Method: Six each candidate drug were prepared by emulsion solvent diffusion method, using varying ratios polymers, i.e., ethyl cellulose polyvinyl alcohol. The evaluated for various parameters including production yield, particle size, polydispersity index, actual content entrapment efficiency. Morphological, structural thermo-analytical evaluations performed techniques. In...
The aim of this study was to fabricate Bacillus Calmette–Guérin (BCG)-loaded microneedle patches using micromould casting technique and compare their efficacy with the injectable counterparts. were formulated sodium alginate (10% w/v) trehalose (20% polymer). characterised optical microscopy, scanning electron microscopy folding endurance. Serum IgG, TLC, granulocyte count, lymphocyte count CRP assessed results compared that intradermal injections alongside controls. showed polymeric had a...
Dexibuprofen (DXIBN) transdermal patches were formulated using various concentrations of selected polymeric excipients (matrix material; ethyl cellulose and polyvinylpyrrolidone, plasticizer (di-N-butyl phthalate), a conventional permeation enhancer (almond oil)). Initial patch formulations evaluated for their physiochemical properties (thickness, moisture uptake, final content, DXIBN content). Also, impact components on resulting tensile strength in vitro used to predict an optimal...
Purpose: To develop polymeric nanosponge based hydrogel system of fluconazole (FZ) for improved delivery topical application.Method: Six different preparations were formulated by oil-in-water (o/w) emulsion solvent diffusion method using various drug to polymer (ethylcellulose, EC) ratios. Polyvinyl alcohol (PVA) and dichloromethane used prepare the aqueous dispersed phases, respectively. The nanosponges (NS) studied entrapment efficiency, particle size, structural properties, size...
Agarose (AG) is a naturally occurring biocompatible marine seaweed extract that converted to hydrocolloid gel in hot water with notable strength. Currently, its mucoadhesion properties have not been fully explored. Therefore, the main aim of this study was evaluate mucoadhesive potential AG binary dispersions combination Carbopol 934P (CP) as preparations. The gels fabricated via homogenization were evaluated for ex vivo mucoadhesion, swelling index (SI), dissolution and stability studies....
The aim of this study was to fabricate celecoxib-loaded chitosan/guar gum (CS/GG) single (SC) and dual (DC) crosslinked hydrogel beads using the ionotropic gelation approach. prepared formulations were evaluated for entrapment efficiency (EE%), loading (LE%), particle size swelling studies. performance assessed by in vitro drug release, ex-vivo mucoadhesion, permeability, ex-in vivo anti-inflammatory EE% found be ~55% ~44% SC5 DC5 beads, respectively. LE% ~11% ~7% showed a matrix-like...
Hypertensive crisis (HC) is an emergency health condition which requires effective management strategy. Over the years, various researchers have developed captopril based fast-dissolving formulations to manage HC; however, primarily, question of personalisation remains unaddressed. Moreover, commercially these are available as in fixed-dose combinations or strengths, so titration dose according patient’s prerequisite challenging achieve. The recent emergence 3D printing technologies has...
The study was aimed at designing and characterizing the ondansetron hydrochloride (OND) bearing agarose (AG), hydroxypropyl methyl cellulose (HPMC) mucoadhesive buccal films employing glycerol as a plasticizer. delivery of remarkably boosted by physical (iontophoresis) chemical enhancement approaches (chemical penetration enhancers). To explore influence different formulation components, i.e., agarose, (HPMC), on various evaluating parameters, tensile strength, swelling index, ex vivo...
A novel mucoadhesive buccal tablet containing flurbiprofen (FLB) and lidocaine HCl (LID) was prepared to relieve dental pain. Tablet formulations (F1-F9) were using variable quantities of agents, hydroxypropyl methyl cellulose (HPMC) sodium alginate (SA). The evaluated for their physicochemical properties, strength mucoadhesion time, swellability index in vitro release active agents. Release both drugs depended on the relative ratio HPMC:SA. However, time better formulations, higher...
The aim of this study is to evaluate the adhesion ability okra gum, which gaining popularity as a tablet binder. For purpose, gum was extracted from pods, and binding strength different concentrations (1%, 3%, 5%) determined quantitatively. Additionally, naproxen sodium tablets were prepared by using binder evaluated for their properties including hardness, friability, disintegration time, dissolution rate. values compared with that pre-gelatinized starch, commonly used results universal...
Paracetamol, a frequently used antipyretic and analgesic drug, has poor compression moldability owing to its low plasticity. In this study, new co-crystals of paracetamol (PCM) with caffeine (as co-former) were prepared delineated. Co-crystals exhibited improved compaction mechanical behavior. A screening study was performed by utilizing number methods namely dry grinding, liquid assisted grinding (LAG), solvent evaporation (SE), anti-solvent addition using various weight ratios starting...
The purpose of this study was to investigate the application piezoelectric inkjet technology in preparation custom-made indomethacin (IMC) films. Indomethacin solutions with and without PVP were printed onto polymeric sheets using a commercial printer. Drug loading varied by selecting machine parameter different dots per inches (DPIs). patches evaluated for particulate morphologies, drug loading, vitro release ex vivo skin permeation anti-inflammatory effects hind paw inflammation model....
Purpose: To develop a new analytical method for the quantitative analysis of miconazole nitrate (MCN) and hydrocortisone (HCA) in pharmaceutical creams.Methods: The study was accomplished three steps. In first stage, spectroscopic developed simultaneous (HCA). For this purpose, serial dilutions both drugs were prepared using ethanol: water (50:50) as solvent system. All solutions analyzed absorbance spectrophotometrically at 205 249 nm MCN HCA, respectively. validated linearity, range,...
Abstract Background This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As empirical rules of dose calculation cannot calculate gender-specific and ignores age-related differences. Methods A PBPK model for healthy population was developed oral (fed fasting) IV administration PK-Sim MoBI® scaled down a virtual prediction in neonates infants, infants toddler, children at pre-school age, school age adolescents. The...
The present study was aimed to prepare and characterize new cocrystals of lornoxicam (LORX), a BCS class II drug employing 1,3-dimethyl urea (DMU) as coformer improve physicochemical, pharmaceutical, pharmacokinetic performance.A screening conducted by three techniques viz. neat grinding, liquid-assisted grinding (LAG), solvent evaporation (SE) using different drug-coformer molar ratios (1:1, 1:2, 1:3). Samples were characterized DSC, PXRD, ATR-FTIR, SEM, intrinsic dissolution rate (IDR)...