A5013804170- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Hydrogels: synthesis, properties, applications
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Intramuscular injections and effects
- Surfactants and Colloidal Systems
- Pharmaceutical studies and practices
- Pancreatic function and diabetes
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Carbohydrate Chemistry and Synthesis
- Chemotherapy-related skin toxicity
- Advanced Polymer Synthesis and Characterization
- Microfluidic and Capillary Electrophoresis Applications
- Proteoglycans and glycosaminoglycans research
- Phytochemistry and Biological Activities
- Nigella sativa pharmacological applications
- Adsorption, diffusion, and thermodynamic properties of materials
- Ginger and Zingiberaceae research
- Polysaccharides and Plant Cell Walls
- Diet and metabolism studies
- Bee Products Chemical Analysis
Bahauddin Zakariya University
2007-2025
Universiti Sains Malaysia
2013-2025
Government College University, Faisalabad
2024
University of the Sciences
2014
Nanostructured lipid carriers (NLCs) loaded with lopinavir (LPV) were prepared by the high-shear homogenization method. The LPV-NLCs formulations freeze-dried using trehalose as a cryoprotectant. In vitro release studies in simulated gastric fluid (pH 1.2) and intestinal 6.8) showed burst release. optimized formulation (LPV-NLC-7-Tres) had particle size (PS), polydispersity index (PdI), zeta potential (ZP) % entrapment efficiency (%EE) of 286.8 ± 1.3 nm, 0.413 0.017, −48.6 0.89 mV 88.31...
The aim of this work was to identify, optimize and use nondestructive process develop nano formulation using polyelectrolyte complexation (PEC) between polymeric nanocarrier Bovine Serum Albumin. Proteins are mostly degraded during preparation loading into nano-carriers which hinders success in protein delivery. Herein, novel PEC consisting model BSA nanogels (NGs), were prepared form self-assembled nanocomplexes (BSA/NGs-PEC). BSA/NGs-PEC obtained by mixing at various weight ratios (1:2,...
Introduction: Insulin is given by injection, because when administered orally, it would be destroyed enzymes in the digestive system, hence only about 0.1% reaches blood circulation. The purpose of present study was to use pH sensitive polyelectrolyte methyl methacrylate (MMA)/itaconic acid (IA) nanogels as carriers an attempt improve absorption insulin orally. Methods: (Ins) incorporated into MMA/IA (NGs) using complexation (PEC) method form Ins/NGs-PEC. Several parameters, including...
The aim of this study was to fabricate celecoxib-loaded chitosan/guar gum (CS/GG) single (SC) and dual (DC) crosslinked hydrogel beads using the ionotropic gelation approach. prepared formulations were evaluated for entrapment efficiency (EE%), loading (LE%), particle size swelling studies. performance assessed by in vitro drug release, ex-vivo mucoadhesion, permeability, ex-in vivo anti-inflammatory EE% found be ~55% ~44% SC5 DC5 beads, respectively. LE% ~11% ~7% showed a matrix-like...
Hypertensive crisis (HC) is an emergency health condition which requires effective management strategy. Over the years, various researchers have developed captopril based fast-dissolving formulations to manage HC; however, primarily, question of personalisation remains unaddressed. Moreover, commercially these are available as in fixed-dose combinations or strengths, so titration dose according patient’s prerequisite challenging achieve. The recent emergence 3D printing technologies has...
The study was aimed at designing and characterizing the ondansetron hydrochloride (OND) bearing agarose (AG), hydroxypropyl methyl cellulose (HPMC) mucoadhesive buccal films employing glycerol as a plasticizer. delivery of remarkably boosted by physical (iontophoresis) chemical enhancement approaches (chemical penetration enhancers). To explore influence different formulation components, i.e., agarose, (HPMC), on various evaluating parameters, tensile strength, swelling index, ex vivo...
Nature represents a basic source of medicinal scaffolds that can develop into potent drugs used in the treatment many diseases.The present study was planned to evaluate combined effects polyherbal methanolic extract herbs (fruit capsicum, bark cinnamon, rhizome turmeric and ginger) were individually well known for their analgesic anti-inflammatory activities. Furthermore, we aimed hydrogel formulation this characterize its potential.Zingiber officinale (R.), Capsicum annuum (L.), Curcuma...
Type 2 diabetes mellitus has been a major health issue with increasing morbidity and mortality due to macrovascular microvascular complications. The urgent need for improved methods control hyperglycemic complications reiterates the development of innovative preventive therapeutic treatment strategies. In this perspective, xanthone compounds in pericarp mangosteen fruit, especially α-mangostin (MGN), have recognized restore damaged pancreatic β-cells optimal insulin release. Therefore,...
Despite several novel and innovative approaches, clinical translation of oral insulin delivery into commercially viable treatment is still challenging due to its poor absorption rapid degradation in GIT. Thus, an insulin-SDS hydrophobic ion pair loaded self-microemulsifying drug system (SMEDDS) was formulated exploit the hypoglycemic effects orally delivered insulin. Insulin initially hydrophobically paired with sodium dodecyl sulphate (SDS) enhance lipophilicity. The successful complexation...
The objective of the present investigation was to design, optimize and characterize gastro retentive floating levofloxacin tablets perform in-vivo evaluation using radiographic imaging. were prepared by polymers i.e hydroxy propyl methyl cellulose (HPMC-K4M) carbopol-940 individually in combination nonaquous granulation method. All Formulations evaluated for swelling index (S.I), behavior in-vitro drug release kinetics. compatibility study with other investigated FTIR, DSC, TGA XRD. Results...
The objective of this work was to develop new pH-sensitive hydrogels deliver gastric mucosal irritating drugs the lower part gastrointestinal tract. For purpose, cross-linked vinyl acetate-co-acrylic acid (VAC-co-AA) were synthesized by using N, methylene bisacrylamide (MBAAm) as a cross-linking agent. Different ratios 90:10, 70:30, 50:50, 30:70, and 10:90 VAC-co-AA synthesized. All compositions 0.15, 0.30, 0.45, 0.60 mol percent MBAAm. Swelling aspirin release studied for 8 hour period....
Extensive research has been carried out for developing nanocarriers to overcome the major barriers preventing success in oral insulin therapy, which includes (a) identification of vivo barriers, (b) incorporation prerequisite characteristics into single nanocarrier, and (c) exclusion use additional potentially toxic chemicals as enzyme inhibitors or permeation enhancers. The present review identifies nanocarrier that could avoid hindrance being faced delivery. An effort is made discuss...
Low dissolution rates of poorly soluble drugs are the factor afflicting their bioavailability. The aim this study is to prepare a centrifugal spinning-based formulation drug, oxcarbazepine, for improvement rate and hence quick action. Sucrose-based microfibers oxcarbazepine were prepared by melt spinning technique using cotton candy machine. characterized Scanning electron microscopy (SEM), PXRD, Differential Calorimetry (DSC) FTIR. optimum was molded into tablets tested in vitro drug...
The conventional dosage forms (tablets, capsules) of ibuprofen have less potential in the suppression pain and inflammation due to their slow dissolution rates lower bioavailability. aim this study was fabricate fibrous solid dispersion for improved rate quick therapeutic action. Drug-loaded microfibers were fabricated using centrifugal melt spinning (CMS) technique from physical mixture sucrose, a hydrophilic polymer, PVP. These fibers characterized by SEM, PXRD, DSC, FTIR spectroscopy....