Verapamil is a calcium channel blocker and highly effective in the treatment of hypertension, angina pectoris, other diseases. However, drug has low bioavailability 20 to 35% due first pass effect. The main objective this study was develop hybrid verapamil-dextran nanostructured lipid carriers (HVD-NLCs) an attempt increase verapamil cellular uptake. formulations were successfully prepared by high-shear homogenization method statistically optimized using 24 full factorial design. HVD-NLCs...

Nanostructured lipid carriers (NLCs) loaded with lopinavir (LPV) were prepared by the high-shear homogenization method. The LPV-NLCs formulations freeze-dried using trehalose as a cryoprotectant. In vitro release studies in simulated gastric fluid (pH 1.2) and intestinal 6.8) showed burst release. optimized formulation (LPV-NLC-7-Tres) had particle size (PS), polydispersity index (PdI), zeta potential (ZP) % entrapment efficiency (%EE) of 286.8 ± 1.3 nm, 0.413 0.017, −48.6 0.89 mV 88.31...

We studied the prevalence of polypharmacy in attenders aged 75 years and over to an emergency department (ED) North London a period 1 month. identified 467 patients this age group. Analysis medications being prescribed revealed at least 82 on medication with potential for adverse interaction. There is need ED-initiated strategies identify interactions pathways allow review.

Introduction: Insulin is given by injection, because when administered orally, it would be destroyed enzymes in the digestive system, hence only about 0.1% reaches blood circulation. The purpose of present study was to use pH sensitive polyelectrolyte methyl methacrylate (MMA)/itaconic acid (IA) nanogels as carriers an attempt improve absorption insulin orally. Methods: (Ins) incorporated into MMA/IA (NGs) using complexation (PEC) method form Ins/NGs-PEC. Several parameters, including...

Post-traumatic seizures cause secondary brain injury, contributing to morbidity and mortality after traumatic injury. Seizure activity may be undetectable if the patient is paralysed ventilated.The effect of prophylactic anticonvulsant therapy on prevention moderate severe injury was studied.A structured systematic literature review performed.There a place for anticonvulsants in prophylaxis early post-traumatic seizures.Further randomised controlled trials are needed firmly establish...

Tuberculosis (TB) is the main infectious disease causing 1.8 million deaths worldwide every year and represents a principal cause of mortality resulting from bacterial infection. The emergence multidrug-resistant strains lack effective anti-TB drugs are threatening future control TB. present multidrug regimen against TB needs daily administration for at least 6 months, patients often fail to follow this complex such long interval, thus leading patient non-compliance treatment related side...

Cefuroxime axetil (CA) is an oral cephalosporin which hydrolyzes rapidly to the active parent compound cefuroxime. CA known have incomplete bioavailability (30–50%) due its poor solubility and enzymatic conversion cefuroxime in gut lumen. In order overcome these drawbacks, a lipid-based self-nanoemulsifying drug delivery system (SNEDDS) has been developed optimized. The SNEDDS formulations were prepared using aqueous phase titration method. greatest self-emulsifying area was found 2:1 Smix...

Background: The antiretroviral protease inhibitor drug lopinavir (LPV) is used to treat HIV-1 infection. LPV known have limited oral bioavailability, which may be attributed its poor aqueous solubility, low efficacy and high first-pass metabolism. Self-nanoemulsifying delivery systems (SNEDDS) for been developed optimised counter the current issues. Methods: titration method was prepare LPV-loaded SNEDDS (LPV-SNEDDS). Six different pseudo-ternary phase diagrams were constructed identify...

ABSTRACT Different Indian therapeutic plants have picked up consideration for their restorative properties against neurodevelopmental disorders lately. Bacopa monnieri (B. monnieri) , being one of them, finds its utilization significantly in the treatment cognition and learning. Despite fact that it possesses such great capacity to treat neurological issues, how precisely confers influence is muddled. This study makes a stride towards knowing which phytochemical associated with granting B....

Alzheimers disease (AD) remains a formidable challenge, necessitating the discovery of effective therapeutic agents targeting β-site amyloid precursor protein cleaving enzyme 1 (BACE1). This study investigates inhibitory potential phytochemicals derived from Bacopa monnieri, plant renowned for its cognitive-enhancing properties, in comparison to established synthetic inhibitors such as Atabecestat, Lanabecestat, and Verubecestat. Utilizing molecular docking advanced computational...

Background: In the acute context, spontaneous haemopneumothorax is a life-threatening condition that can occur without any radiological abnormalities and may be caused by thoracic vascular aberrancy. Case presentation: We discuss case of healthy 24-year-old man who visited our emergency department complaining left sided chest pain shortness breath. He had previously tertiary care facility’s for same complaint day been released following normal CXR blood tests. His repeat x-ray revealed...