A5008776062- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Analytical Methods in Pharmaceuticals
- Pharmaceutical studies and practices
- Nanoparticle-Based Drug Delivery
- Natural Antidiabetic Agents Studies
- Crystallization and Solubility Studies
- Bioactive Natural Diterpenoids Research
- Ethnobotanical and Medicinal Plants Studies
- Antibiotics Pharmacokinetics and Efficacy
- Drug-Induced Hepatotoxicity and Protection
- Phytochemicals and Antioxidant Activities
- Pharmaceutical Economics and Policy
- Phytochemistry and Biological Activities
- Computational Drug Discovery Methods
- Analytical Chemistry and Chromatography
- Hydrogels: synthesis, properties, applications
- 3D Printing in Biomedical Research
- Pharmacogenetics and Drug Metabolism
- Advancements in Transdermal Drug Delivery
- Chronic Myeloid Leukemia Treatments
- Polysaccharides Composition and Applications
- Pharmacological Effects of Natural Compounds
- Advances in Cucurbitaceae Research
- Inflammatory mediators and NSAID effects
University of the Punjab
2015-2024
Qarshi University
2024
International Medical University
2005-2020
Government College University, Faisalabad
2019
Bahauddin Zakariya University
2019
Allama Iqbal Medical College
2016-2017
University of Lahore
2008-2017
Hospital Tuanku Ja’afar
2011
Universiti Teknologi MARA
2009
Islamia University of Bahawalpur
1999-2003
Folate grafted and thiolated chitosan was synthesized wrapped on the surface of mixed phosphatidylcholine based nanoliposomes (NLs) to improve oral absorption targeted pharmacological activity anti-cancer drugs against breast cancer. In this study, a derived thiomer, having intrinsic properties P-glycoprotein (P-gp) efflux pump inhibition, mucoadhesion controlled drug release at target site, exploited performance docetaxel (DTX) loaded NLs for better pharmacokinetics, activity, liposomal...
Purpose: This study was aimed to develop doxorubicin-loaded quaternary ammonium palmitoyl glycol chitosan (DOX–GCPQ) nanoformulation that could enable DOX delivery and noninvasive monitoring of drug accumulation biodistribution at tumor site utilizing self-florescent property doxorubicin. Materials methods: DOX–GCPQ amphiphilic polymeric nanoformulations were prepared optimized using artificial neural network (ANN) characterized for surface morphology by atomic force microscopy, particle...
Purpose: To develop and evaluate nanosponge (NS) based sustained release formulations of naproxen (NAP) ibuprofen (IBU).Method: Six each candidate drug were prepared by emulsion solvent diffusion method, using varying ratios polymers, i.e., ethyl cellulose polyvinyl alcohol. The evaluated for various parameters including production yield, particle size, polydispersity index, actual content entrapment efficiency. Morphological, structural thermo-analytical evaluations performed techniques. In...
Gastric ulcer is the most prevalent disorder affecting a large population. Rosa brunonii Lindl. fruit (RBF) has traditionally been used to treat stomach pains. Therefore, current work aimed isolate, characterize, and investigate gastro-protective effect of chloroform extract (RBFCE) against ethanol-induced gastric ulcers in rats. Quercetin 3-O-glucoside (QUE-G) was isolated characterized by modern spectroscopic techniques. RBFCE orally administered at 250 mg/kg, 500 750 mg/kg doses for ten...
Minor illnesses are usually treated in home and community contexts. Despite, or perhaps because of, their commonness, responses to minor illness poorly researched, especially outside developed countries. The aim of this study was qualitatively explore the range everyday symptoms that people Pakistan might experience types they make illnesses. information gathered inform design a larger project prospectively Twenty-four participants, aged between 18 55 years, were approached through snowball...
Poor aqueous solubility and dissolution limit the oral bioavailability of Biopharmaceutics Classification System (BCS) class II drugs. In this study, we aimed to improve raloxifene hydrochloride (RLX), a BCS drug, using self-microemulsifying drug delivery system (SMEDDS). Based on solubilities RLX, Capryol 90, Tween 80/Labrasol ALF, polyethylene glycol 400 (PEG-400) were selected as oil, surfactant mixture, cosurfactant, respectively. Pseudo-ternary phase diagrams constructed determine...
To evaluate in vivo antioxidant activity of latex and leaves methanol extract Euphorbia helioscopia using mice as experimental animals.The plant was collected, identified, dried under shade, ground to fine powder extraction done. Latex collected bottles by cutting the stem. Oxidative stress induced with acute toxic dose paracetamol administered intrperitoneally. (600 1 200 mg/kg) orally, once a day, were given for two weeks. Then oxidative biomarkers measured tissue homogenates serum.Leaves...
Objective: To evaluate acute toxic effects of Euphorbia helioscopia in order to assure the safety and usefulness herbal remedy.Materials methods: The Organization for Economic Cooperation Development (OECD) chemical testing guidelines No. 425 oral toxicity were followed this study. Mice divided into three groups (n = 5). Group I served as control. Groups II III administered methanol extract E. leaves latex orally at dose 2000 mg/kg, respectively. Then, all animals observed two weeks. Blood...
Clinical success of effective gene therapy is mainly hampered by the insufficiency safe and efficient internalization a transgene to targeted cellular site. Therefore, development nanocarrier system one fundamental challenges transfer therapeutic genes diseased cells. Polyamidoamine (PAMAM) dendrimer has been used as an non-viral vector (dendriplexes) but toxicity unusual biodistribution induced terminal amino groups (-NH2) limit its in vivo applications. Hence, state art lipid modification...
This study aimed to evaluate complementary and alternative medicine (CAM) use among Malaysian diabetic patients. Subjects for this case—control were randomly selected from the pool of patients who attending diabetes clinics, at Hospital Tuanku Jaa’far, Seremban, Malaysia. Perceived effect CAM use, reasons starting CAM, sociodemographic factors collected (n=230). Blood glucose levels also recorded. Almost half population (49.6%, 114/230) using together with conventional treatment diabetes....
Background: Medication errors in chemotherapy are frequent and lead to patient morbidity mortality, as well increased rates of re-admission length stay, considerable extra costs. Objective: This study investigated the proposition that computerised ordering reduces incidence severity protocol errors. Method: A physician order entry (C-CO) with clinical decision support system was developed in-house, including standardised definitions, automation pharmacy distribution, checks, labeling...
A novel mucoadhesive buccal tablet containing flurbiprofen (FLB) and lidocaine HCl (LID) was prepared to relieve dental pain. Tablet formulations (F1-F9) were using variable quantities of agents, hydroxypropyl methyl cellulose (HPMC) sodium alginate (SA). The evaluated for their physicochemical properties, strength mucoadhesion time, swellability index in vitro release active agents. Release both drugs depended on the relative ratio HPMC:SA. However, time better formulations, higher...
Polymeric nanomaterials, hybridized with lipid components,<italic>e.g.</italic>phosphocholine or fatty acids, are currently being explored for efficient nano-platforms hydrophobic drugs.
Paracetamol, a frequently used antipyretic and analgesic drug, has poor compression moldability owing to its low plasticity. In this study, new co-crystals of paracetamol (PCM) with caffeine (as co-former) were prepared delineated. Co-crystals exhibited improved compaction mechanical behavior. A screening study was performed by utilizing number methods namely dry grinding, liquid assisted grinding (LAG), solvent evaporation (SE), anti-solvent addition using various weight ratios starting...