Cancer is a severe disease that results in death all countries of the world. A nano-based drug delivery approach best alternative, directly targeting cancer tumor cells with improved cellular uptake. Different types nanoparticle-based carriers are advanced for treatment cancer, and to increase therapeutic effectiveness safety therapy, many substances have been looked into as carriers. Lipid-based nanoparticles (LBNPs) significantly attracted interest recently. These natural biomolecules...

Skin is an attractive site for drug administration partly because of its easy accessibility and favorable properties (e.g., less invasiveness high patient compliance) over some other common routes administration. Despite this, the efficiency in transdermal delivery has been largely limited by poor skin permeation. To address this problem, study reports generation oleic acid-containing vesicles, which can enhance while showing good stability disruption. Upon being loaded into a complex gel,...

Herbal medicine, as an integral component of oriental has assimilated into the lives Asian people for millennia. The therapeutic efficiency herbal extracts and ingredients has, however, been limited by various factors, including lack targeting capacity poor bioavailability. Hydrogels are hydrophilic polymer networks that can imbibe a substantial amount fluids. They biocompatible, may enable sustained drug release. Hydrogels, therefore, have attracted widespread studies in pharmaceutical...

Hydrogels are soft materials consisting of a three-dimensional network polymer chains. Over the years, hydrogels with different compositions have been developed as drug carriers for diverse biomedical applications, ranging from cancer therapy and wound care to treatment neurodegenerative inflammatory diseases. Most these carriers, however, designed only deliver single agents. Carriers based on co-delivery multiple agents, release rate each co-delivered agents tunable, lacking. This study...

The development of combination therapy has received great attention in recent years because its potential to achieve higher therapeutic efficacy than that achieved by mono-drug therapy. Carriers for effective and stimuli-responsive co-delivery multiple agents, however, are highly deficient at the moment. To address this need, study reports generation multi-component hydrogel beads incorporated with reduced graphene oxide (rGO). prepared incorporating doxorubicin (DOX)-loaded gelatine (GL)...

Purpose: Magnetic nanoparticles have been used in diverse pharmaceutical applications because they can potentially be to target specific sites. In the present work, a new type of nanocomposites is designed as carrier controlled bioactive agent delivery. Methods: Amine-functionalized magnetic (amine-MNPs) are coupled with carboxymethyl chitosan (CMC) generate nanocomposites, namely MNPs-CMC, which further loaded doxorubicin (DOX) produce MNPs-CMC-DOX. The generated characterized by using...

Hydrogels are an important class of soft materials that find use in bioactive agent delivery. Because their high water content, hydrogels generally show poor mechanical strength. Long-term wear and tear physiological conditions may lead to damage the hydrogel structure during delivery agents. This results burst uncontrolled release. One strategy solve this problem is incorporate self-healing properties into a so can heal fractures automatically restore original properties. The objectives...

Gelatine methacryloyl (GM) shows high biocompatibility and is extensively used in tissue engineering; however, few works have explored the use of GM bioactive agent delivery. This study adopts a microfluidic approach involving flow-focusing geometry for microgel fabrication. generates highly monodisperse microgels whose size can be tuned by altering various fabrication conditions (including concentration gel-forming solution flow rates different phases). By using tetracycline hydrochloride...

The present study reports the generation of 2-hydroxyethyl starch microparticles for co-delivery and controlled release multiple agents. obtained are characterized by using Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction analysis, energy-dispersive electron microscopy. By ofloxacin ketoprofen as drug models, sustainability is examined at pH 1.2, 5.4, 6.8 37 °C, with Fickian diffusion being found to be major mechanism controlling kinetics release....

This study reports the synthesis of surface-modified chitosan (CS) coated with reduced graphene oxide/nickel oxide (rGO/NiO) as a multifunctional drug carrier anti-microbial, target-specific, and stimuli-responsive capacities. CS, rGO, NiO nanoparticles are selected due to their pH-responsiveness, large surface area, ROS generating-capacity, respectively. The CS/rGO/NiO nanocomposites (NCs) synthesized using solvothermal approach. Glutaraldehyde is used crosslink CS rGO/NiO enhance stability...

Polyelectrolyte complexes formed between chitosan (CS) and anionic polymers have attracted increasing interest in drug delivery. In this study, CS is copolymerized with hypromellose via a coupling reagent-mediated approach to form water-soluble, nontoxic derivative, namely hypromellose-graft-CS (HC), which subsequently complexed carboxymethylcellulose (CMC) generate polyampholytic hydrogel. When compared conventional CS, HC highly water-soluble across wide pH range, has substantially higher...