Muhammad Sarfraz

ORCID: 0000-0002-0516-4966
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About
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Research Areas
  • X-ray Diffraction in Crystallography
  • Crystallization and Solubility Studies
  • Advanced Drug Delivery Systems
  • Nanoparticle-Based Drug Delivery
  • Drug Solubulity and Delivery Systems
  • Synthesis and biological activity
  • RNA Interference and Gene Delivery
  • Computational Drug Discovery Methods
  • Advancements in Transdermal Drug Delivery
  • Phytochemicals and Antioxidant Activities
  • Crystal structures of chemical compounds
  • Insect-Plant Interactions and Control
  • Natural Antidiabetic Agents Studies
  • Metal complexes synthesis and properties
  • Cholinesterase and Neurodegenerative Diseases
  • Drug Transport and Resistance Mechanisms
  • Crystallography and molecular interactions
  • Pharmaceutical studies and practices
  • Insect Pest Control Strategies
  • Essential Oils and Antimicrobial Activity
  • Analytical Methods in Pharmaceuticals
  • Inhalation and Respiratory Drug Delivery
  • Pharmacological Effects of Natural Compounds
  • Phytochemistry and Biological Activities
  • Insect Resistance and Genetics

Al Ain University
2017-2025

Dow University of Health Sciences
2016-2025

Tehran University of Medical Sciences
2024

University of Agriculture Faisalabad
2024

Shalamar Hospital
2021-2022

Independence University
2017-2021

Independent University
2017-2021

Islamia University of Bahawalpur
2006-2021

University of Alberta
2010-2021

University of Sargodha
2010-2021

Abstract: The diamondback moth (DBM), Plutella xylostella (L.) (Lep., Plutellidae), is one of the most destructive insect pests crucifers worldwide. It was first crop reported to be resistant DDT and now in many crucifer‐producing regions it has shown significant resistance almost every insecticide applied field including biopesticides such as crystal toxins from Bacillus thuringiensis spinosyns Saccharopolyspora spinosa . In certain parts world, economical production become impossible...

10.1111/j.1439-0418.2005.00930.x article EN Journal of Applied Entomology 2005-04-01

Selecting insect-resistant plant varieties is a key component of integrated management programs oligophagous pests such as diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), but rigorous research on important life history parameters P. in relation to host resistance rare. We evaluated six conventional brassicaceous species, namely, Brassica napus L. 'Q2', B. rapa L., juncea Czern., carinata oleracea and Sinapis alba two herbicide-tolerant cultivars, 'Liberty' 'Conquest'...

10.1603/0022-0493(2007)100[215:roscbt]2.0.co;2 article EN Journal of Economic Entomology 2007-02-01

At present, much of the attention within tuberculosis (TB) management is spent on microbiological cure, and its impact health-related quality life (HRQoL) either undervalued or seldom considered. The aim this study was to evaluate TB treatment HRQoL new smear positive pulmonary (PTB) patients. Moreover, we also aimed determine whether selected socio-demographic clinical variables were predictive variability in scores over time. This a prospective follow-up PTB patients who diagnosed at chest...

10.1186/1477-7525-12-19 article EN cc-by Health and Quality of Life Outcomes 2014-01-01

Multidrug resistance of cancer cells to cytotoxic drugs still remains a major obstacle the success chemotherapy in treatment. The development new drug candidates which may serve as P-glycoprotein (P-gp) efflux pump inhibitors is promising strategy. Selenium analogues natural products, such flavonoids, offer an interesting motif from perspective design. Herein, we report biological evaluation novel hybrid compounds, bearing both flavone core (compounds 1–3) or bioisosteric analogue 4–6) and...

10.3390/ph13120453 article EN cc-by Pharmaceuticals 2020-12-11

Microneedle patches are promising transdermal drug delivery platforms with minimal invasiveness in a painless manner. patch could be alternate route for of drugs having poor solubility and low bioavailability. This research work therefore, aimed to develop characterize microneedle thiolated chitosan (TCS) polyvinyl acetate (PVA) the systemic dydrogesterone (DYD). TCS-PVA-based was fabricated 225 needles length 575 µm sharp pointed end. Different ratios were employed investigate effects...

10.1016/j.jsps.2023.03.007 article EN cc-by-nc-nd Saudi Pharmaceutical Journal 2023-03-15

The aim of the current study was to explore potential human plasma-derived exosomes as versatile carriers for drug delivery by employing various active and passive loading methods. Exosomes were isolated from plasma using differential centrifugation ultrafiltration method. Drug achieved sonication freeze thaw methods, facilitating effective encapsulation within delivery. Each approach examined its effectiveness, efficiency ability preserve membrane stability. Methotrexate (MTX), a weak acid...

10.1016/j.jsps.2024.102096 article EN cc-by-nc-nd Saudi Pharmaceutical Journal 2024-05-06

Wheat aphid, Sitobion avenae (Fab.), is a serious pest of wheat crop across the world. The present study was conducted to evaluate potentials water plant extracts Azadirachta indica (neem) or Eucalyptus camaldulensis and entomopathogenic fungi (EPF); Beauveria bassiana Metarhizium anisopliae against aphid species. After 5 days applications, combined mixture B. eucalyptus extract caused maximum mortality rate (87%). While combination with neem showed least (54%). Fecundity negatively affected...

10.1186/s41938-018-0101-9 article EN cc-by Egyptian Journal of Biological Pest Control 2018-12-01

Liposomes have been studied as a colloidal carrier in drug delivery systems, especially for oral administration. However, their low structural integrity the gut is still major shortcoming. Membrane disruptive effects of physiological bile salts small intestine result premature release prior to intestinal absorption. Thus, we analyzed stabilizing effect sodium deoxycholate when incorporated into nano-sized liposomes.Cefotaxime-loaded liposomes were prepared with different concentrations...

10.18433/j3ck88 article EN cc-by Journal of Pharmacy & Pharmaceutical Sciences 2017-08-28

Fibroblast growth factor receptors 1 (FGFR1) is an emerging target for the development of anticancer drugs. Uncontrolled expression FGFR1 strongly associated with a number different types cancers. Apart from few FGFR inhibitors, family members have not been thoroughly studied to produce clinically effective The application proper computational techniques may aid in understanding mechanism protein-ligand complex formation, which provide better notion developing potent inhibitors. In this...

10.1080/07391102.2023.2187638 article EN Journal of Biomolecular Structure and Dynamics 2023-03-10
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