A5018689961- Venomous Animal Envenomation and Studies
- Crystallography and molecular interactions
- Enzyme Production and Characterization
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Healthcare and Venom Research
- Moringa oleifera research and applications
- HIV/AIDS drug development and treatment
- Advanced Drug Delivery Systems
- IL-33, ST2, and ILC Pathways
- Osteoarthritis Treatment and Mechanisms
- Toxin Mechanisms and Immunotoxins
- Inflammatory mediators and NSAID effects
- Nanoparticles: synthesis and applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Research on Leishmaniasis Studies
- Synthesis of Tetrazole Derivatives
- Transgenic Plants and Applications
- Synthesis of β-Lactam Compounds
- Plant biochemistry and biosynthesis
- Chemical synthesis and alkaloids
- Polysaccharides and Plant Cell Walls
- Biochemical and Structural Characterization
- Microbial Natural Products and Biosynthesis
- Ubiquitin and proteasome pathways
Shenzhen University
2025
Shenzhen Technology University
2025
Institute of Food Science and Technology
2025
Abbottabad University of Science and Technology
2019-2024
COMSATS University Islamabad
2018-2024
Jiangnan University
2013-2023
The aim of the current study was to explore potential human plasma-derived exosomes as versatile carriers for drug delivery by employing various active and passive loading methods. Exosomes were isolated from plasma using differential centrifugation ultrafiltration method. Drug achieved sonication freeze thaw methods, facilitating effective encapsulation within delivery. Each approach examined its effectiveness, efficiency ability preserve membrane stability. Methotrexate (MTX), a weak acid...
Cancer is the most common cause of mortality worldwide. There dire need modern strategies-such as surface modification nanocarriers-to combat this global illness. Incorporation active targeting ligands has arisen a novel platform for specific tumor targeting. The aim current study was to formulate PEG-protamine complex (PPC) doxorubicin (DOX) treatment breast cancer (BC). DOX coupling with PEG can enhance cell-penetrating ability: combating resistance in MDA-MB 231 cells. Ionic gelation...
Azurin is a natural protein produced by Pseudomonas aeruginosa that exhibits potential anti-tumor, anti-HIV, and anti-parasitic properties. The current study aimed to investigate the of azurin against breast cancer using both in silico vitro analyses. amino acid sequence was used predict its secondary tertiary structures, along with physicochemical properties, online software. resulting structure validated confirmed Ramachandran plots ERRAT2. mature comprises 128 acids, top-ranked obtained...
The objective of the study was to develop PEGylated protamine letrozole nanoparticles combat human breast cancer by modifying release pattern letrozole. Breast is amongst most prevalent diseases in women due overactivity epidermal growth factor receptor 2 (HER2). PEG-protamine nanoparticle formulation designed and optimized alter drug. size, morphology, structure NP were characterized FTIR, XRD, Zetasizer, SEM analysis. result showed irregular shape have size ranging from 258 nm 388 nm,...
Lectins are the oligomeric sugar-specific glycoprotein of nonimmune origin, involved in multiple biological recognition process, and have capacity to perform a wide variety physiological functions including antifungal, antiviral, antitumor, cell agglutination. The main objective current study was prepare lectin protein-loaded chitosan-TPP nanoparticles via ionic gelation methods with different CS/TPP ratios investigate anticancer potential against HepG2 cells. best ratio showed mean particle...
Nanobiotechnology is the intersection of nanotechnology and biology, where nano systems are applied to help study biological systems. There a growing interest researchers in application improving efficacy photodynamic therapy. In this study, antioxidant, photodynamic, anticancer, antibacterial potential plant extracts silver nanoparticles (AgNPs) were investigated. order synthesize AgNPs, 10 g dried powder Tecoma stans Narcissus tazetta was boiled deionized water (100 ml) mixed with aqueous...
Fusion proteins are designed to achieve new functionality or improved properties synergistically by incorporating multiple protein domains into one complex. The fusion of two genes translate a recombinant for cancer treatment can enhance the bioactivity drug and introduce novel candidate with wide range applications in pharmaceuticals biotechnology. Interleukin-24 (IL-24) is growth-suppressing apoptosis inducing cytokine while melittin natural honeybee derived cationic polypeptide having...
Carbamazepine (CBZ) is an antiepileptic drug having low bioavailability due to its hydrophobic nature. In the current study, efforts are made investigate effect of dicarboxylic acid coformer spacer groups (aliphatic chain length) on physicochemical properties, relative humidity (RH) stability, and oral CBZ cocrystals. Slurry crystallization technique was employed for preparation cocrystals with following coformers: adipic (AA), glutaric (GA), succinic (SA), malonic (MA). Powder X-ray...
Purpose: To prepare and characterise doxorubicin nanopatrticles study their drug delivery in breast cancer.Methods: Doxorubicin nanoparticles were prepared by ionic gelation method using sodium alginate as polymer. The formulations optimized cross-linking CaCl2 with at different concentrations. Zeta sizer Nano ZS (UK) was used to determine the mean particle size distribution of nanoparticle preparations. shape external morphologies evaluated scanning electron microscopy (SEM). Drug release...
Iron homeostasis is vital for normal physiology, but in the majority of circumstances, like iron overload, this equilibrium upset leading to free plasma. This condition with excess known as hemochromatosis, which has been linked many side effects, including cancer and liver cirrhosis. The current research aimed investigate active molecules from Streptomyces sp. isolated extreme environment Bahawalpur deserts. strain was characterized using 16 S rRNA sequencing. Chemical analysis ethyl...
The present work is designed to synthesize 2,5-disubstituted-1,3,4-oxadiazole derivatives 5a-5d as snake venom phospholipase A 2 (PLA ) inhibitors.The was isolated from Naja oxiana by pressing their glands below eyes perform anti-PLA activity.The compounds showed good PLA inhibitory potential, especially 5d exhibited excellent activity having IC 50 value 0.002 mM (0.01 > p 0.001) followed 5c 0.003 0.001).Compounds 5a and 5b have values 0.027 (p < 0.014 respectively.The docking results that...
Background: Snakebite is a commonly neglected tropical disease globally. According to the World Health Organization, tens of thousands deaths have been reported due venomous snakes previously. Among such snakes, vipers genus Echis are extremely important clinically. In folk medicine, plants used for treatment snakebites even though snake venom antiserum only efficacious currently known. Objectives: This study was conducted investigate inhibitory potential extracts from Pakistani medicinal...
There is a huge amount of data available on genes interacting with celecoxib in terms drug response; however, these studies are inconsistent. To overcome this inconsistency, there dire need to integrate the and categorize celecoxib. We conducted extraction from published articles (n=30511) reference celecoxib-gene interactions online literature sources using semi-automated text mining approach. Scoring algorithms were developed by assigning every gene score depending evidence according...
Interleukin (IL)-24 or melanoma differentiation-associated gene-7 (MDA7) belongs to the family of cytokines initially obtained from malignant tissues and manifests itself in various types cells (of a large size). Thus, they play crucial part anemias. The current study aims analyze activation involvement IL-4 thalassemia patients. For this purpose, population 50 patients was randomly selected prescription pattern blood samples for IL-24 by utilizing RT-PCR procedure. Extraction mRNA followed...