A5101675851- Natural product bioactivities and synthesis
- Protein Tyrosine Phosphatases
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Reproductive Biology and Fertility
- Microbial Natural Products and Biosynthesis
- Natural Compound Pharmacology Studies
- Sirtuins and Resveratrol in Medicine
- Reproductive System and Pregnancy
- Phytochemicals and Antioxidant Activities
- Marine Sponges and Natural Products
- Carbohydrate Chemistry and Synthesis
- Atherosclerosis and Cardiovascular Diseases
- Pancreatic function and diabetes
- Eicosanoids and Hypertension Pharmacology
- Heat shock proteins research
- Medicinal Plant Pharmacodynamics Research
- Antimicrobial Peptides and Activities
- Ziziphus Jujuba Studies and Applications
- Chronic Lymphocytic Leukemia Research
- Speech and Audio Processing
- Traditional and Medicinal Uses of Annonaceae
- Bioactive natural compounds
- Medicinal Plants and Neuroprotection
- Herbal Medicine Research Studies
COMSATS University Islamabad
2020-2025
Abbottabad University of Science and Technology
2020-2024
Gyeongsang National University
2015-2019
BGC Trust University Bangladesh
2011-2019
Korea University
2012
Dhaka International University
2011-2012
Philippine General Hospital
2012
Al Noor Hospitals
2012
Dietary isoflavones, daidzein and genistein are of huge interest in the nutraceutical field due to their practical application postmenopause complications. This study is first report an efficient method prepare isoflavone rich soybean leaves (soyleaves) which edible food stuff Asian countries. The preharvest treatment ethylene highly stimulated level soyleaves. Annotation quantification metabolites were determined by UPLC-Q-TOF-MS HPLC. Phenolic soyleaves mostly kaempferol glycosides, but...
Protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase are important targets to treat obesity diabetes, due their deep correlation with insulin leptin signalling, glucose regulation. The methanol extract of Paulownia tomentosa fruits showed potent inhibition against both enzymes. Purification this led eight geranylated flavonoids (1-8) displaying dual PTP1B α-glucosidase. isolated compounds were identified as flavanones (1-5) dihydroflavonols (6-8). Inhibitory potencies these varied...
ABSTRACT Dicliptera bupleuroides has been used traditionally for treating various ailments in many countries. Its detailed phytochemical profiling and pharmacological evaluation cancer based on reactive oxygen species (ROS) mitochondrial membrane potential (MMP) analysis along with caspase activation studies not done previously. This study was conducted of D. by using ultra‐high performance liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (UHPLC‐QTOF‐MS) to evaluate its...
Type 2 Diabetes (T2D) is a chronic metabolic disorder, considered the fastest growing pandemic of 21 st century. Meta-inflammation pivotal characteristic T2D. Hyperactivated PTP1B, NLRP3, and AIM2 inflammasomes are major regulators inflammation. The concept diabetes as an inflammatory disease has changed pathogenic vision T2D hence, compounds that mitigateinflammation in setting under limelight research. Current study aimed to evaluatethe anti-inflammatory potency Viscosol, novel PTP1B...
Objectives: Several studies demonstrated the antioxidant and anti-inflammatory role of melatonin celecoxib. This study is designed to explore underlying mechanism hepatoprotective effects celecoxib against ethanol-induced hepatotoxicity by morphological, biochemical approaches.Materials methods: Adult male rats were divided into five groups: saline, ethanol, melatonin, administered for 11 consecutive days after ethanol injection. Biochemical analyses performed determination glutathione...
Acetaminophen (N-acetyl p-aminophenol or APAP) is used worldwide for its antipyretic and anti-inflammatory potential. However, APAP overdose sometimes causes severe liver damage. In this study, we elucidated the protective effects of carveol in injury, using molecular silico approaches. Male BALB/c mice were divided into two experimental cohorts, to identify best dose further assess role nuclear factor E2-related factor; erythroid 2; p45-related 2 (Nrf2) pathway. The results demonstrated...
The aim of the present study was to investigate beneficial effect polydatin (PD), glycoside form resveratrol, on embryo development in vitro. Oocytes were aspirated from ovaries Korean Hanwoo cows and cultured until Day 8 a humidified atmosphere 5% CO2 air at 38.5°C. Protein gene expression levels determined through confocal microscopy reverse transcription–polymerase chain reaction respectively, whereas number total apoptotic cells blastocysts using Hoechst 33342 staining terminal...
Ziziphus nummularia is an important source of valuable phytoconstituents, which are widely used in traditional medicine system Indo-Pak sub-continent. In this study we investigated the distribution phenolic compounds fruit pericarps six different genotypes (ZNP01-06) Z. growing unexplored hilly areas Pakistan. The methanolic extracts these were screened for total content (TPC), flavonoid (TFC), antioxidant, and cholinesterase inhibitory potentials. observed biological potentials explained...
The objective of the study was to develop PEGylated protamine letrozole nanoparticles combat human breast cancer by modifying release pattern letrozole. Breast is amongst most prevalent diseases in women due overactivity epidermal growth factor receptor 2 (HER2). PEG-protamine nanoparticle formulation designed and optimized alter drug. size, morphology, structure NP were characterized FTIR, XRD, Zetasizer, SEM analysis. result showed irregular shape have size ranging from 258 nm 388 nm,...
Diabetes mellitus is one of a major worldwide concerns, regulated by either defects in secretion or action insulin, both. Insulin signaling down-regulation has been related with over activity protein tyrosine phosphatase 1B (PTP1B) enzyme, which promising target for the treatment diabetes mellitus. Herein, guided separation methanol extract (95%) Dodonaea viscosa aerial parts afforded nine (1-9) polyphenolic compounds, all them were identified through spectroscopic data including 2D NMR and...
Type 2 diabetes mellitus (T2DM) is one of the most common forms diabetes. We are living in middle a global epidemic. Emerging pieces evidence suggesting increased expression protein tyrosine phosphatase 1B (PTP1B) pancreas and adipose tissues during T2DM. The negative regulation insulin signaling pathway by PTP1B helps researchers to consider it as potential therapeutic target for treatment resistance its associated complications. From literature, we found that compound...
Activity-guided phytochemical investigation of the methanol extract Usnea longissima led to isolation nine (1–9) phenolic metabolites, including compounds 6 and 7, which were reported for first time from this species. All isolated completely characterized through spectroscopic analysis, 2D NMR HREIMS data. Individually, activity each purified compound was assessed against bacterial neuraminidase (BNA), most them displayed dose-dependent inhibition. Among compounds, 2 3 exhibited significant...