A5078682094- Computational Drug Discovery Methods
- Enzyme function and inhibition
- Shoulder Injury and Treatment
- Livestock Management and Performance Improvement
- Agricultural Economics and Practices
- Molecular Biology Techniques and Applications
- PI3K/AKT/mTOR signaling in cancer
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and biological activity
- Reproductive Biology and Fertility
- Single-cell and spatial transcriptomics
- Protein Tyrosine Phosphatases
- Shoulder and Clavicle Injuries
- Bioinformatics and Genomic Networks
- Machine Learning in Healthcare
- Data Visualization and Analytics
- Genetic and phenotypic traits in livestock
- Reliability and Agreement in Measurement
- Artificial Intelligence in Healthcare and Education
- Genetic diversity and population structure
- Chemical Synthesis and Analysis
- Sirtuins and Resveratrol in Medicine
- Pancreatic function and diabetes
- Emotion and Mood Recognition
National Institute of Immunology
2025
Sam Higginbottom Institute of Agriculture
2025
Institute of Engineering
2025
Gyeongsang National University
2020-2024
Exactech (United States)
2024
Babasaheb Bhimrao Ambedkar University
2021-2024
Basque Center for Materials, Applications and Nanostructures
2024
Delhi Technological University
2020-2023
National Institute Of Technology Silchar
2018-2022
All India Institute of Medical Sciences
2022
Abstract Background Machine learning techniques can identify complex relationships in large healthcare datasets and build prediction models that better inform physicians ways assist patient treatment decision-making. In the domain of shoulder arthroplasty, machine appears to have potential anticipate patients’ results after surgery, but this has not been well explored. Questions/purposes (1) What is accuracy predict American Shoulder Elbow Surgery (ASES), University California Los Angeles...
Malathion is an organophosphate chemical (OPC) and a toxic contaminant that adversely impacts food quality, human health, biodiversity, the environment. Due to its small size unavailability of sensitive sensors, detection malathion remains challenging task. Often chromatographic methods employed analyze OPCs suffer from several shortcomings, including cost, immobility, laboriousness, unsuitability for point-of-care settings. Hence, developing specific diagnostic sensor quick inexpensive...
Owing to several mutations, the oncogene Kirsten rat sarcoma 2 viral homolog (KRAS) is activated in majority of cancers, and targeting it has been pharmacologically challenging. In this study, using an silico approach comprised pharmacophore modeling, molecular docking, dynamics simulations, potential KRAS G12D inhibitors were investigated. A ligand-based common feature model was generated identify framework necessary for effective inhibition. The chemical features selected two hydrogen bond...
Abstract Health care delivery processes consist of complex activity sequences spanning organizational, spatial, and temporal boundaries. Care is human-directed so these can have wide variations in cost, quality, outcome making systemic process analysis, conformance testing, improvement challenging. We designed developed an interactive visual analytic exploration discovery tool used it to explore clinical data from 5784 pediatric asthma emergency department patients.
The present study was conducted to determine antifungal activity of three different concentrations (5, 10, and 15%) cow urine against fungal pathogens ( Fusarium oxysporum, Rhizoctonia solani , Sclerotium rolfsii ) isolated from infected plants Methi Bhindi that showed symptoms damping off wilting disease by poison food technique. extent growth test fungi in plates poisoned with lesser when compared the control plates. Among these at 15% concentration most effective. When organisms were...
The rapid spread of COVID-19, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a worldwide health emergency. Unfortunately, to date, very small number remedies have been be found effective against SARS-CoV-2 infection. Therefore, further research required achieve lasting solution this deadly disease. Repurposing available drugs and evaluating natural product inhibitors target proteins could an approach accelerate drug discovery development. With strategy...
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase portraying quintessential role in cellular proliferation and survival. Aberrations the mTOR signaling pathway have been reported numerous cancers including thyroid, lung, gastric ovarian cancer, thus making it therapeutic target. To attain this objective, an silico investigation was designed, employing pharmacophore modeling approach. A structure-based (SBP) model exploiting key features selective inhibitor, Torkinib...
The World Health Organization has declared COVID-19 as a global health emergency. is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and highlights an urgent need for therapeutics. Here, we have employed series of computer-aided drug repurposing campaign to discover inhibitors RNA dependent polymerase (RdRp) Nsp15/EndoU. Subsequently, MD simulation been performed observe dynamic behavior identified leads at the active site RdRp Nsp15. We successfully novel lead...
The cyclin-dependent kinase 7 (CDK7) plays a crucial role in regulating the cell cycle and RNA polymerase-based transcription. Overexpression of this is linked with various cancers humans due to its dual involvement development. Furthermore, emerging evidence has revealed that inhibiting CDK7 anti-cancer effects, driving development novel more cost-effective inhibitors enhanced selectivity for over other CDKs. In present investigation, pharmacophore-based approach was utilized identify...
The pandemic caused by SARS-CoV-2 (SCoV-2) has impacted the world in many ways and virus continues to evolve produce novel variants with ability cause frequent global outbreaks. Although advent of vaccines abated burden, they were not effective against all SCoV-2. This trend warrants shifting focus on development small molecules targeting crucial proteins viral replication machinery as therapeutic solutions. PLpro is a enzyme having multiple roles during life cycle well-established drug...
Spleen tyrosine kinase (SYK) is an essential mediator of immune cell signaling and has been anticipated as a therapeutic target for autoimmune diseases, notably rheumatoid arthritis, allergic rhinitis, asthma, cancers. Significant attempts have undertaken in recent years to develop SYK inhibitors; however, limited success achieved due poor pharmacokinetics adverse effects inhibitors. The primary goal this research was identify potential inhibitors having high affinity, selectivity based on...