A5025034359- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Liver Disease Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Reproductive Biology and Fertility
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Sperm and Testicular Function
- Reproductive Health and Technologies
- Immune Response and Inflammation
- Genomics, phytochemicals, and oxidative stress
- Adipose Tissue and Metabolism
- Ovarian function and disorders
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- GDF15 and Related Biomarkers
- Curcumin's Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Phytochemistry and Biological Activities
- Biochemical effects in animals
- Antioxidants, Aging, Portulaca oleracea
- Prenatal Substance Exposure Effects
- Calpain Protease Function and Regulation
- Aldose Reductase and Taurine
Abdul Wali Khan University Mardan
2018-2025
Gyeongsang National University
2013-2024
Riphah International University
2018-2021
Melatonin acts as a pleiotropic agent in various age-related neurodegenerative diseases. In this study, we examined the underlying neuroprotective mechanism of melatonin against D-galactose-induced memory and synaptic dysfunction, elevated reactive oxygen species (ROS), neuroinflammation neurodegeneration. D-galactose was administered (100 mg/kg intraperitoneally (i.p.)) for 60 days. After 30 days administration, vehicle (same volume) or (10 mg/kg, i.p.) Our behavioral (Morris water maze...
Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as Alzheimer's disease, Parkinson's and Huntington's disease. Lipopolysaccharide (LPS) an essential component of the gram-negative bacterial cell wall acts a potent stimulator that mediates neurodegeneration. Quercetin natural flavonoid abundantly found in fruits vegetables has been shown to possess forms desirable biological activity including anti-inflammatory antioxidant properties. This study aimed...
Abstract Toll-like receptor 4 (TLR4) signaling in the brain mediates autoimmune responses and induces neuroinflammation that results neurodegenerative diseases, such as Alzheimer’s disease (AD). The plant hormone osmotin inhibited lipopolysaccharide (LPS)-induced TLR4 downstream signaling, including activation of TLR4, CD14, IKKα/β, NFκB, release inflammatory mediators, COX-2, TNF-α, iNOS, IL-1β. Immunoprecipitation demonstrated colocalization AdipoR1 receptors BV2 microglial cells, which...
Oxidative stress and energy imbalance strongly correlate in neurodegenerative diseases. Repeated concussion is becoming a serious public health issue with uncontrollable adverse effects the human population, which involve cognitive dysfunction even permanent disability. Here, we demonstrate that traumatic brain injury (TBI) evokes oxidative stress, disrupts homeostasis, boosts neuroinflammation, further contributes to neuronal degeneration mouse brain. We also melatonin (an anti-oxidant...
In order to increase the bioavailability of hydrophilic unstable drugs like anthocyanins, we employed a polymer-based nanoparticles approach due its unique properties such as high stability, improved and water-soluble drug loading efficiency. Anthocyanins constitute subfamily flavonoids that possess anti-oxidative, anti-inflammatory neuroprotective properties. However, anthocyanins are because their phenolic hydroxyl groups easily oxidized into quinones, causing reduced biological activity....
Herein, we assayed the antioxidant and anti-inflammatory potential of caffeine in a lipopolysaccharide (LPS)-injected mouse model neurodegeneration synaptic impairment. For this purpose, LPS was injected for two weeks on an alternate-day basis (250 µg/kg/i.p. total seven doses), while daily four (30 mg/kg/i.p/four weeks). According to our findings, there significant increase level reactive oxygen species (ROS), as evaluated from levels lipid peroxidation (LPO) ROS assays. Also, expression...
Abstract Background Recently, we and other researchers reported that brain metabolic disorders are implicated in Alzheimer’s disease (AD), a progressive, devastating incurable neurodegenerative disease. Hence, novel therapeutic approaches urgently needed to explore potential targets/agents for the treatment of AD. The neuronal adiponectin receptor 1 (AdipoR1) is an emerging target intervention metabolic-associated We aimed validate this hypothesis in-depth effects osmotin-derived...
Nonalcoholic fatty liver disease (NAFLD) is a chronic associated with inflammation, fibrosis, and cirrhosis greater risk of hepatocarcinoma. steatohepatitis (NASH) persistent progressive form NAFLD. Recent evidence suggested that ertugliflozin, sodium-glucose cotransporter 2 inhibitor (SGLT2), suppresses NAFLD development in patients type diabetes mellitus (T2DM). The objective this study was to determine the impact ertugliflozin on improving T2DM function enzymes.
Abstract Elevated serum levels of inflammatory mediators in conditions such as PCOS reflect a low-grade chronic inflammation and this has been attributed to be associated with insulin-resistance PCOS. Therefore, insulin-sensitizing agents are suggested improve both reproductive well metabolic aspects This study aimed compare the effects metformin taken alone that combination pioglitazone on menstrual cycle, hormonal parameters, insulin resistance, biomarkers women One hundred six...
Ethanol induces oxidative stress and its exposure during early developmental age causes neuronal cell death which leads to several neurological disorders. We previously reported that vitamin C can protect against ethanol-induced apoptotic in the developing rat brain. Here, we extended our study understand therapeutic efficacy of stress, neuroinflammation mediated neurodegeneration postnatal day 7 (PND7) rat. A single episode ethanol (5g/kg) subcutaneous administration significantly induced...
Objectives: Several studies demonstrated the antioxidant and anti-inflammatory role of melatonin celecoxib. This study is designed to explore underlying mechanism hepatoprotective effects celecoxib against ethanol-induced hepatotoxicity by morphological, biochemical approaches.Materials methods: Adult male rats were divided into five groups: saline, ethanol, melatonin, administered for 11 consecutive days after ethanol injection. Biochemical analyses performed determination glutathione...
Alzheimer's disease (AD) is the most predominant cause of dementia, considered a progressive decline in cognitive function that ultimately leads to death. AD has posed substantial challenge records medical science over past century, representing etiology dementia with high prevalence rate. Neuroinflammation common characteristic various central nervous system (CNS) pathologies like AD, primarily mediated by specialized brain immune and inflammatory cells, such as astrocytes microglia. The...
Acetaminophen (N-acetyl p-aminophenol or APAP) is used worldwide for its antipyretic and anti-inflammatory potential. However, APAP overdose sometimes causes severe liver damage. In this study, we elucidated the protective effects of carveol in injury, using molecular silico approaches. Male BALB/c mice were divided into two experimental cohorts, to identify best dose further assess role nuclear factor E2-related factor; erythroid 2; p45-related 2 (Nrf2) pathway. The results demonstrated...
Chronic ethanol exposure is known to cause neuronal damage in both humans and experimental animal models. Ethanol treatment induces neurotoxicity via the generation of reactive oxygen species (ROS), while anthocyanins (extracted from black soybean) ascorbic acid (vitamin C) are free radical scavengers that can be used as neuroprotective agents against ROS. In this study underlying potential soybean vitamin C was determined. For purpose, adult rats were exposed 10% (v/v) for 8 weeks, followed...
Major depressive disorder (MDD) is a progressive deteriorating mental state with feeling of worthlessness and frequent mood swings. Several studies reported the favorable effects natural drug substances on MMD associated oxidative stress neuroinflammation. The present study attempted to examine whether carveol could affect lipopolysaccharide- (LPS-) induced depression, if so, how nuclear factor E2-related (Nrf2) contributed neuroprotective mechanistically. Two experimental cohorts were used...