A5005393877- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Vaccine Coverage and Hesitancy
- Adipose Tissue and Metabolism
- Sexual Differentiation and Disorders
- Circadian rhythm and melatonin
- Medicinal Plants and Neuroprotection
- Immune Response and Inflammation
- Phytochemicals and Antioxidant Activities
- Bartonella species infections research
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plants and Bioactive Compounds
- Prenatal Substance Exposure Effects
- Curcumin's Biomedical Applications
- S100 Proteins and Annexins
- Adipokines, Inflammation, and Metabolic Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Sirtuins and Resveratrol in Medicine
- Aldose Reductase and Taurine
University of Science and Technology Bannu
2024
University of Haripur
2024
Saidu Teaching Hospital
2024
Northwest General Hospital and Research Center
2022-2023
Gyeongsang National University
2015-2021
Khyber Medical College
2020-2021
National Institute of Health
2021
University of the Punjab
2019
Aga Khan University
2017
Aga Khan University
2013
Glial activation and neuroinflammation play significant roles in apoptosis as well the development of cognitive memory deficits. Neuroinflammation is also a critical feature pathogenesis neurodegenerative disorders such Alzheimer Parkinson's diseases. Previously, hesperetin has been shown to be an effective antioxidant anti-inflammatory agent. In present study, vivo vitro analyses were performed evaluate neuroprotective effects lipopolysaccharide (LPS)-induced neuroinflammation, oxidative...
Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as Alzheimer's disease, Parkinson's and Huntington's disease. Lipopolysaccharide (LPS) an essential component of the gram-negative bacterial cell wall acts a potent stimulator that mediates neurodegeneration. Quercetin natural flavonoid abundantly found in fruits vegetables has been shown to possess forms desirable biological activity including anti-inflammatory antioxidant properties. This study aimed...
Oxidative stress and energy imbalance strongly correlate in neurodegenerative diseases. Repeated concussion is becoming a serious public health issue with uncontrollable adverse effects the human population, which involve cognitive dysfunction even permanent disability. Here, we demonstrate that traumatic brain injury (TBI) evokes oxidative stress, disrupts homeostasis, boosts neuroinflammation, further contributes to neuronal degeneration mouse brain. We also melatonin (an anti-oxidant...
Oxidative stress has been considered the main mediator in neurodegenerative disease and normal aging processes. Several studies have reported that accumulation of reactive oxygen species (ROS), elevated oxidative stress, neuroinflammation result cellular malfunction. These conditions lead to neuronal cell death aging-related disorders such as Alzheimer’s (AD) Parkinson’s disease. Chronic administration d-galactose (d-gal) for a period 10 weeks causes ROS generation neuroinflammation,...
The aim of the current study was to explore underlying neuroprotective mechanisms curcumin (50 mg/kg, for six weeks) against ethanol (5 mg/kg i.p., induced oxidative stress and inflammation-mediated cognitive dysfunction in mice. According our findings, triggered reactive oxygen species (ROS), apoptosis, neuroinflammation, memory impairment, which were significantly inhibited with administration curcumin, as assessed by ROS, lipid peroxidation (LPO), Nrf2/HO-1 (nuclear factor erythroid...
Glutamate-induced excitotoxicity, oxidative damage, and neuroinflammation are believed to play an important role in the development of a number CNS disorders. We recently reported that high dose glutamate could induce AMPK-mediated neurodegeneration postnatal day 7 (PND7) rat brain. Yet, mechanism glutamate-induced stress brain is not well understood. Here, we report for first time neuroinflammation, neuroprotection by polyphenolic anthocyanins PND7. PND7 brains, SH-SY5Y, BV2 cells treated...
Melatonin is a well-known potent endogenous antioxidant pharmacological agent with significant neuroprotective actions. Here in the current study, we explored nuclear factor erythroid 2-related 2 (Nrf2) gene-dependent mechanism underlying effects of acute melatonin against ethanol-induced elevated reactive oxygen species (ROS)-mediated neuroinflammation and neurodegeneration developing rodent brain. In vivo rat pups were co-treated single dose ethanol (5 g/kg, subcutaneous (S.C.)) (20 mg/kg,...
Phytomedicine based natural flavonoids have potent antioxidant, anti-inflammatory, and neuroprotective activities against neurodegenerative diseases. The aim of the present study is to investigate antioxidant potential effects fisetin (natural flavonoid) central nervous system (CNS)-insult, lipopolysaccharide (LPS)-induced reactive oxygen species (ROS), neuroinflammation, neurodegeneration, synaptic/memory deficits in adult mice. mice were injected intraperitoneally (i.p.) with LPS (250...
Abstract Background Recently, we and other researchers reported that brain metabolic disorders are implicated in Alzheimer’s disease (AD), a progressive, devastating incurable neurodegenerative disease. Hence, novel therapeutic approaches urgently needed to explore potential targets/agents for the treatment of AD. The neuronal adiponectin receptor 1 (AdipoR1) is an emerging target intervention metabolic-associated We aimed validate this hypothesis in-depth effects osmotin-derived...
Traumatic brain injury (TBI) is a global risk factor that leads to long-term cognitive impairments. To date, the disease remains without effective therapeutics because of multifactorial nature disease. Here, we demonstrated activation c-Jun N-terminal kinase (JNK) involved in multiple pathological features TBI. Therefore, investigated disease-modifying therapeutic potential JNK-specific inhibitor (SP600125) TBI mice. Treating 2 different models mice with SP600125 for 7 days dramatically...
Ethanol induces oxidative stress and its exposure during early developmental age causes neuronal cell death which leads to several neurological disorders. We previously reported that vitamin C can protect against ethanol-induced apoptotic in the developing rat brain. Here, we extended our study understand therapeutic efficacy of stress, neuroinflammation mediated neurodegeneration postnatal day 7 (PND7) rat. A single episode ethanol (5g/kg) subcutaneous administration significantly induced...
Brain injury is a significant risk factor for chronic gliosis and neurodegenerative diseases. Currently, no treatment available neuroinflammation caused by the action of glial cells following brain injury. In this study, we investigated quinpirole-mediated activation dopamine D2 receptors (D2R) in mouse model traumatic (TBI). We also neuroprotective effects quinpirole (a D2R agonist) against cell-induced secondary to TBI adult mice. After injury, injected into mice at dose 1 mg/kg daily...
Douepia tortuosa (D. tortuosa) has not been evaluated for its pharmacological significance prior to this.This study was aimed identify bioactive compounds occurring in water (AQE), methanol (ME), ethyl acetate (EAE) and n-hexane (HE) extracts of D. evaluate antimicrobial antioxidant potential.The microscopic analysis the plant powder presented characteristic starch granules calcium oxalate crystals.The ME best extraction yield value campared other solvents.Maximum soluble phenolics content,...
Brain injuries are a serious global health issue and the leading cause of neurodegeneration. To date, there is no proper cure treatment for brain-injury-induced neuropathological conditions because lack sufficient knowledge failure to develop drug due multi-pathological in brain. Herein, we explored neurotherapeutic effects Nicotinamide (NAM), against brain injury-induced neurodegeneration behavioral problems. Treating injured mouse brains with NAM, 7 days, significantly ameliorated several...