A5100634663- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical effects in animals
- Regulation of Appetite and Obesity
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Ectopic Pregnancy Diagnosis and Management
- Immune cells in cancer
- Bone fractures and treatments
- Hip and Femur Fractures
- Polysaccharides and Plant Cell Walls
- Vascular Malformations Diagnosis and Treatment
- Heavy Metal Exposure and Toxicity
- Cholesterol and Lipid Metabolism
- Nuclear Receptors and Signaling
- Neurofibromatosis and Schwannoma Cases
- Sepsis Diagnosis and Treatment
- Medicinal Plants and Bioactive Compounds
- Curcumin's Biomedical Applications
Washington University in St. Louis
2023-2024
Hope Center for Neurological Disorders
2023-2024
Konkuk University
2024
Gyeongsang National University
2014-2022
Presbyterian Medical Center
2021-2022
University of Ulsan
2016-2019
Asan Medical Center
2016-2019
Ulsan College
2016-2019
Catholic University of Korea
2017
Jeju National University
2014
Recent single-cell RNA sequencing studies have revealed distinct microglial states in development and disease. These include proliferative-region-associated microglia (PAMs) developing white matter disease-associated (DAMs) prevalent various neurodegenerative conditions. PAMs DAMs share a similar core gene signature. However, the extent of dynamism plasticity these states, as well their functional significance, remains elusive, partly due to lack specific tools. Here, we generated an...
Glutamate-induced excitotoxicity, oxidative damage, and neuroinflammation are believed to play an important role in the development of a number CNS disorders. We recently reported that high dose glutamate could induce AMPK-mediated neurodegeneration postnatal day 7 (PND7) rat brain. Yet, mechanism glutamate-induced stress brain is not well understood. Here, we report for first time neuroinflammation, neuroprotection by polyphenolic anthocyanins PND7. PND7 brains, SH-SY5Y, BV2 cells treated...
We evaluated the predictive value of serum biomarkers and various clinical risk scales for 28-day mortality community-acquired pneumonia (CAP). Serum including procalcitonin (PCT) C-reactive protein (CRP) were in emergency department. Scores severity index (PSI); CURB65 (confusion, urea, respiration, blood pressure; age >65 years); Infectious Disease Society America (IDSA) American Thoracic (ATS) guidelines severe CAP; Acute Physiology, Chronic Health Evaluation (APACHE) II; Sequential Organ...
Abstract Background Recently, we and other researchers reported that brain metabolic disorders are implicated in Alzheimer’s disease (AD), a progressive, devastating incurable neurodegenerative disease. Hence, novel therapeutic approaches urgently needed to explore potential targets/agents for the treatment of AD. The neuronal adiponectin receptor 1 (AdipoR1) is an emerging target intervention metabolic-associated We aimed validate this hypothesis in-depth effects osmotin-derived...
Recent studies on neurodegeneration have focused dysfunction of CNS energy metabolism as well proteinopathies. Adiponectin (ADPN), an adipocyte-derived hormone, plays a major role in the regulation insulin sensitivity and glucose homeostasis peripheral organs via adiponectin receptors. In spite accumulating evidence that has neuroprotective properties, underlying receptors not been illuminated. Here, using gene therapy-mediated suppression with shRNA, we found receptor 1 (AdipoR1) induces...
Here, we have unveiled the effects of cycloastragenol against Aβ (Amyloid-beta)-induced oxidative stress, neurogenic dysfunction, activated mitogen-activated protein (MAP) kinases, and mitochondrial apoptosis in an Aβ-induced mouse model Alzheimer’s disease (AD). The was developed by stereotaxic injection amyloid-beta (5 μg/mouse/intracerebroventricular), given at a dose 20 mg/kg/day/p.o for 6 weeks daily. For biochemical analysis, used immunofluorescence Western blotting. Our findings...
Age-related decline in mitochondrial function and oxidative stress plays a critical role neurodegeneration. Lactate dehydrogenase-B (LDHB) is glycolytic enzyme that catalyzes the conversion of lactate, an important brain energy substrate, into pyruvate. It has been reported LDHB pattern changes during ageing. Yet very little known about effect deficiency on pathology. Here, we have used Ldhb knockout (Ldhb-/-) mice to test hypothesis stress-mediated neuroinflammation were generated by...
Oxidative stress and insulin resistance play major roles in numerous neurodegenerative diseases, including Alzheimer’s disease (AD). A high-fat diet induces obesity-associated oxidative stress, neuronal resistance, microglial activation, neuroinflammation, which are considered important risk factors for neurodegeneration. Obesity-related metabolic dysfunction is a factor cognitive decline. The present study aimed to elucidate whether chronic consumption of (HFD; 24 weeks) can induce amyloid...
The study was aimed at analyzing the protective effects of gintonin in an amyloid beta‐ (A β ‐) induced Alzheimer’s disease (AD) mouse model. For development A ‐induced AD model, amyloid‐ 1-42 ) peptide stereotaxically injected into brains mice. Subsequently, administered a dose 100 mg/kg/day/per oral (p.o) for four weeks daily, and its were evaluated by using western blotting, fluorescence analysis brain sections, biochemical tests, memory‐related behavioral evaluations. To elucidate...
Tyrosine-protein kinase (Syk) plays a potential role in neuroinflammation and adaptive immune responses several neurodegenerative conditions. Seeing the significant of Syk pathophysiology neurodegeneration, pharmacological inhibitors have been developed. One known is BAY61-3606, which has shown efficacies Alzheimer’s disease (AD) through regulating amyloid production. However, little about its neurodegeneration. Our finding showed that expression was up-regulated by lipopolysaccharide...
Abstract Background Extracellular amyloid‐β (Aβ) deposition as neuritic plaques and intracellular accumulation of hyperphosphorylated, aggregated tau neurofibrillary tangles (NFT) are two the characteristic hallmarks in Alzheimer’s disease (AD). The regional progression brain atrophy AD highly correlates with but not amyloid mechanisms tau‐mediated neurodegeneration clear. Innate immune responses represent a common pathway for initiation some neurodegenerative diseases. To date, little is...
O-cyclic phytosphingosine-1-phosphate (cPS1P) is a novel and chemically synthesized sphingosine metabolite derived from (S1P). This study was undertaken to unveil the potential neuroprotective effects of cPS1P on two different mouse models Parkinson's disease (PD). The used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neuron specific enolase promoter human alpha-synuclein (NSE-hαSyn) Korl transgenic mice. MPTP injected for five consecutive days alternate six weeks intraperitoneally....
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder typified by several neuropathological features including amyloid-beta (Aβ) plaque and neurofibrillary tangles (NFTs). Cholesterol retention oxidative stress (OS) are the major contributors of elevated β- γ-secretase activities, leading to excessive Aβ deposition, signifying importance altered cholesterol homeostasis OS in progression Aβ-mediated neurodegeneration cognitive deficit. However, effect on metabolism...
Abstract Introduction We evaluated the radiologic and clinical outcomes of a lateral incision single plate with single-incision double plating in elderly patients osteoporotic distal femoral fractures. Materials methods performed retrospective study 82 cases fractures from May 2004 to June 2018. Group A consisted 42 who underwent single-plate fixation. B 40 double-plate The mean patient age was 77 years (67–87 years) 76 (64–86 groups B, respectively. All were for procedure duration, time...
Recent single-cell RNA sequencing studies have revealed distinct microglial states in development and disease. These include proliferative region-associated microglia (PAM) developing white matter disease-associated (DAM) prevalent various neurodegenerative conditions. PAM DAM share a similar core gene signature other functional properties. However, the extent of dynamism plasticity these states, as well their significance, remains elusive, partly due to lack specific tools. Here, we report...
This study compared the food quality of domesticated(RT-DS) and freshwater (RT-F) rainbow trouts Oncorhynchus mykiss. The proximate composition RT-DS was 73.8% moisture, 20.6% crude protein, 4.2% lipid, 1.1% ash similar to RT-F. No differences were found in red color, odor taste intensities, calcium, potassium between RT-F based on Hunter a values, volatile basic nitrogen content, intensity using an electronic nose, tongue. total amino acid contents, taurine, glutamic acid, glycine, alanine...
Recently, “mature” silkworms (MS) of Bombix mori have been considered as a potential nutraceutical, with number health benefits reported for steamed and lyophilized MS powder (SMSP). However, no obesity-related effects SMSP. In the present study, anti-obesity SMSP were investigated in adult mice vivo, aged 12 weeks at onset drug administration, fed normal diet (ND) high-fat (HFD), respectively, weeks. significantly suppressed body weight gain, intra-abdominal adipose tissue, food efficiency...