A5060951883- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- S100 Proteins and Annexins
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Immune cells in cancer
- Curcumin's Biomedical Applications
- Natural product bioactivities and synthesis
- Protein Structure and Dynamics
- Immune Response and Inflammation
- Computational Drug Discovery Methods
- Advanced Glycation End Products research
- Stress Responses and Cortisol
- Traumatic Brain Injury and Neurovascular Disturbances
- Amino Acid Enzymes and Metabolism
- Antioxidants, Aging, Portulaca oleracea
- Neurological Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Aluminum toxicity and tolerance in plants and animals
- Nuclear Receptors and Signaling
- Heavy Metal Exposure and Toxicity
- Cholesterol and Lipid Metabolism
Gyeongsang National University
2018-2021
Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as Alzheimer's disease, Parkinson's and Huntington's disease. Lipopolysaccharide (LPS) an essential component of the gram-negative bacterial cell wall acts a potent stimulator that mediates neurodegeneration. Quercetin natural flavonoid abundantly found in fruits vegetables has been shown to possess forms desirable biological activity including anti-inflammatory antioxidant properties. This study aimed...
Oxidative stress and energy imbalance strongly correlate in neurodegenerative diseases. Repeated concussion is becoming a serious public health issue with uncontrollable adverse effects the human population, which involve cognitive dysfunction even permanent disability. Here, we demonstrate that traumatic brain injury (TBI) evokes oxidative stress, disrupts homeostasis, boosts neuroinflammation, further contributes to neuronal degeneration mouse brain. We also melatonin (an anti-oxidant...
The receptor for advanced glycation end products (RAGE), a pattern recognition signaling event, has been associated with several human illnesses, including neurodegenerative diseases, particularly in Alzheimer’s disease (AD). Vanillic acid (V.A), flavoring agent, is benzoic derivative having broad range of biological activities, antioxidant, anti-inflammatory, and neuroprotective effects. However, the underlying molecular mechanisms V.A exerting neuroprotection are not well investigated....
Abstract Background Glycine is the smallest nonessential amino acid and has previously unrecognized neurotherapeutic effects. In this study, we examined mechanism underlying neuroprotective effect of glycine (Gly) against neuroapoptosis, neuroinflammation, synaptic dysfunction, memory impairment resulting from d -galactose-induced elevation reactive oxygen species (ROS) during onset neurodegeneration in brains C57BL/6N mice. Methods After vivo administration -galactose ( -gal; 100 mg/kg/day;...
Ischemic stroke is characterized by permanent or transient obstruction of blood flow, which initiates a cascading pathological process, starting from acute ATP loss to subsequent membrane depolarization, glutamate excitotoxicity, and calcium overload. Melatonin potent antioxidant that exerts protective effects in different experimental models. In this study, melatonin were demonstrated proteomic silico approach. The study identified differentially expressed proteins 2D gel electrophoresis...
Cadmium (Cd) is an environmental contaminant, which a potential risk factor in the progression of aging-associated neurodegenerative diseases. Herein, we have assessed effects chronic administration Cd on cellular oxidative stress and its associated Alzheimer's disease (AD) pathologies animal models. Two groups mice were used, one group administered with saline other (1 mg/kg/day; intraperitoneally) for 3 months. After behavioral studies, molecular/biochemical (Immunoblotting, ELISAs, ROS,...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that represents 60–70% of all dementia cases. AD characterized by the formation and accumulation amyloid-beta (Aβ) plaques, neurofibrillary tangles, neuronal cell loss. Further Aβ in brain induces oxidative stress, neuroinflammation, synaptic memory dysfunction. In this study, we investigated antioxidant neuroprotective effects natural triterpenoid lupeol Aβ1-42 mouse model AD. An Intracerebroventricular injection (i.c.v.)...
Brain injury is a significant risk factor for chronic gliosis and neurodegenerative diseases. Currently, no treatment available neuroinflammation caused by the action of glial cells following brain injury. In this study, we investigated quinpirole-mediated activation dopamine D2 receptors (D2R) in mouse model traumatic (TBI). We also neuroprotective effects quinpirole (a D2R agonist) against cell-induced secondary to TBI adult mice. After injury, injected into mice at dose 1 mg/kg daily...
Disruptions in brain energy metabolism, oxidative damage, and neuroinflammation are commonly seen traumatic injury (TBI). Microglial activation is the hallmark of neuroinflammation. After injury, microglia also act as a double-edged sword with distinctive phenotypic changes. Therefore, therapeutic applications to potentiate towards pro-inflammatory response following have become focus attention recent years. Here, current study, we investigated hypothesis that 17β-estradiol could rescue...
Brain injuries are a serious global health issue and the leading cause of neurodegeneration. To date, there is no proper cure treatment for brain-injury-induced neuropathological conditions because lack sufficient knowledge failure to develop drug due multi-pathological in brain. Herein, we explored neurotherapeutic effects Nicotinamide (NAM), against brain injury-induced neurodegeneration behavioral problems. Treating injured mouse brains with NAM, 7 days, significantly ameliorated several...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder typified by several neuropathological features including amyloid-beta (Aβ) plaque and neurofibrillary tangles (NFTs). Cholesterol retention oxidative stress (OS) are the major contributors of elevated β- γ-secretase activities, leading to excessive Aβ deposition, signifying importance altered cholesterol homeostasis OS in progression Aβ-mediated neurodegeneration cognitive deficit. However, effect on metabolism...
: Mechanistically, neurotoxic insults provoke Ca2+-mediated calpain activation, which cleaves the cytoplasmic region of membrane-embedded p35 and produces its truncated form p25. Upon physical interaction, cyclin-dependent kinase 5 (Cdk5) p25 forms hyperactivated Cdk5/p25 complex causes severe neuropathological aberrations including hyperphosphorylated tau-mediated neurofibrillary tangles formation, Alzheimer's symptoms, neuronal death. Therefore, inhibition may relieve p-tau-mediated...
Abstract Backgroung Brain injury is a major risk factor for the development of chronic neurodegenerative diseases. The disease still lacks potential candidate to treat brain associated neurodegeneration. In present study we aims investigate expression Dopamin D2 receptor in cortical region as well striatum injured mouse and further explored neuroprotective effects selective D2R agonist quinpirole against injury-associated neuropathological events after injury.Methods order test our...