A5040789818- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Alzheimer's disease research and treatments
- Cardiac Valve Diseases and Treatments
- Tryptophan and brain disorders
- Infective Endocarditis Diagnosis and Management
- Nutrition and Health in Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Medicinal Plants and Neuroprotection
- Lipid metabolism and disorders
- Graphene and Nanomaterials Applications
- Cardiac Arrhythmias and Treatments
- Potassium and Related Disorders
- Biochemical Analysis and Sensing Techniques
- Hospital Admissions and Outcomes
- Cholinesterase and Neurodegenerative Diseases
- Hepatitis B Virus Studies
- Medicinal Plants and Bioactive Compounds
- Circular RNAs in diseases
- Infectious Encephalopathies and Encephalitis
- Inflammatory mediators and NSAID effects
- Aortic Disease and Treatment Approaches
- Adipokines, Inflammation, and Metabolic Diseases
- Nanoparticle-Based Drug Delivery
- Mechanical Circulatory Support Devices
Louisiana State University Health Sciences Center Shreveport
2022
Neurology, Inc
2022
Gyeongsang National University
2016-2021
West Virginia University
2021
Hospital for Special Surgery
2021
University of Malakand
2021
Reading Hospital
2017-2020
University of Illinois Chicago
2020
Advocate Christ Medical Center
2019-2020
Ras al-Khaimah Medical and Health Sciences University
2019
Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as Alzheimer's disease, Parkinson's and Huntington's disease. Lipopolysaccharide (LPS) an essential component of the gram-negative bacterial cell wall acts a potent stimulator that mediates neurodegeneration. Quercetin natural flavonoid abundantly found in fruits vegetables has been shown to possess forms desirable biological activity including anti-inflammatory antioxidant properties. This study aimed...
Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disease, pathologically characterized by accumulation of aggregated amyloid beta (Aβ) in brain. Here, we describe for first time development a new, pioneering nanotechnology-based drug delivery approach potential therapies diseases, particularly AD. We demonstrated fluorescent carboxyl magnetic Nile Red particles (FMNPs) to brains normal mice using functionalized field (FMF) composed positive- and negative-pulsed...
The aim of the current study was to explore underlying neuroprotective mechanisms curcumin (50 mg/kg, for six weeks) against ethanol (5 mg/kg i.p., induced oxidative stress and inflammation-mediated cognitive dysfunction in mice. According our findings, triggered reactive oxygen species (ROS), apoptosis, neuroinflammation, memory impairment, which were significantly inhibited with administration curcumin, as assessed by ROS, lipid peroxidation (LPO), Nrf2/HO-1 (nuclear factor erythroid...
Abstract Aims Despite recent advances in guideline‐directed therapy, rehospitalization rates for acute decompensated heart failure (ADHF) remain high. Recently published studies demonstrated the emerging role of hypochloraemia as a predictor poor outcomes patients with ADHF. This study sought to determine correlation between low serum chloride and 30 day hospital readmission Methods results We retrospectively reviewed electronic medical records 1504 who were admitted one 700 bed US tertiary...
Introduction: Transcatheter mitral valve-in-valve (ViV) & valve-in-ring (ViR) are relatively novel therapeutic alternatives for patients with degenerated bioprostheses or failed annuloplasty rings whose reoperative risk is too high. The predominant procedural access both procedures transapical transseptal. However, whether there differences in outcomes of this procedure using transseptal versus has not yet been defined. Methods: We conducted a systematic review all published articles from...
MicroRNAs (miRNAs) are small non-coding RNA molecules that control the post-transcriptional gene expression. They play a pivotal role in regulation of important physiological processes. Variations miRNA genes coding for mature sequences have been implicated several diseases. However, association variants miRNAs with Type 2 Diabetes Mellitus (T2DM) Pakistani population is rarely reported. Therefore, current study was designed to investigate rs11614913 T/C (MIR196A2), rs2910164 G/C (MIR146A),...
The aim of this study was the evaluation prevalence pregnancy-induced hypertension among teenage pregnancies in a tertiary care setup. This descriptive case series conducted at Gynaecology & Obstetrics Department from December 2023 to June 2024. A total 163 pregnant women age range 10-19 years with gestation more than 20 weeks were enrolled study. PIH diagnosed if blood pressure ≥140/90 mmHg on least two occasions. participants followed different stages pregnancy. Data analysis done...
Since 2013, the National Resident Matching Program (NRMP) has asked all programs to declare themselves be "all in" or out" for NRMP. Before this rule was enacted, program directors who were surveyed expressed concerns about what they anticipated with change, including resources increased applications and potential delays residency start times.This study investigated positive negative effects of change on recruiting seen from perspective internal medicine (IM) directors.In mixed model...
INTRODUCTION Euglycemic diabetic ketoacidosis (EDKA) is a clinical triad comprising of blood glucose (BG) levels<200mg/dL, increased anion gap (AG) metabolic acidosis and ketonemia or ketonuria. It remains one the most serious complications diabetes as in absence hyperglycemia, DKA may be overlooked leading to delay appropriate diagnosis management. CLINICAL CASE A 43-year old male with history uncontrolled type 1 DM 20 years, complicated by peripheral neuropathy, retinopathy, ESRD on...
Objective. The purpose of the study is to compare rate complications in Mayo`s repair with mesh repair. (Preperitoneal approach) Design. Comparative study. Place and Duration Study. Nishtar Hospital Multan during period January 2001 August 2003. Patients Methods. Only patients fully reducible hernias were included Unfit having serious cardiac respiratory illness, obstructive strangulated paraumbilical hernia excluded from Two groups comprising 25 each made on random basis operated (Mayo`s...
Objectives: To determine the prevalence of malnutrition in children with congenital heart disease (CHD). Methods: A cross-sectional study was conducted among 300 diagnosed CHD who were being managed pediatric cardiology clinics. As part study, various anthropometric measurements such as height, weight, and mid-upper arm circumference (MUAC) recorded for each child. The assessment determined based on Z score, where a score below -2 denoted moderate to severe malnutrition, -1 indicated mild...
Background: Aetiological factors of Protein-Calorie-Malnutrition (PCM) in underdeveloped countries are an established fact. An increase number children with grade-III PCM secondary to myriad reasons has been noted recently. This study aimed recognize the aetiological among admitted patients Ayub teaching hospital Abbottabad. Methods: Severe acutely malnourished (SAM) 6?60 months age were selected following non probability random sampling technique. The chosen according WHO criteria...