A5010087568- Synthesis and biological activity
- Computational Drug Discovery Methods
- Advancements in Transdermal Drug Delivery
- Cholinesterase and Neurodegenerative Diseases
- Medicinal Plants and Neuroprotection
- Histone Deacetylase Inhibitors Research
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Cannabis and Cannabinoid Research
- Natural Antidiabetic Agents Studies
- Biochemical effects in animals
- Aldose Reductase and Taurine
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- RNA Interference and Gene Delivery
- Blood Pressure and Hypertension Studies
- Estrogen and related hormone effects
- Lipid Membrane Structure and Behavior
- Phytochemicals and Antioxidant Activities
- Synthesis and Characterization of Heterocyclic Compounds
- Ethnobotanical and Medicinal Plants Studies
- Crop Yield and Soil Fertility
- Liver Disease Diagnosis and Treatment
- Curcumin's Biomedical Applications
- Tannin, Tannase and Anticancer Activities
Riphah International University
2018-2024
Pakistan Agricultural Research Council
2024
Pharmac
2020-2024
Islamia University of Bahawalpur
2014-2024
Lahore College for Women University
2023
The University of Sydney
2015-2021
University of Manchester
2020
Czech Academy of Sciences, Institute of Biotechnology
2020
COMSATS University Islamabad
2020
Abbott (Germany)
2020
Oxidative stress-mediated neuroinflammatory events are the hallmark of neurodegenerative diseases. The current study aimed to synthesize a series novel succinamide derivatives and further investigate neuroprotective potential these compounds against scopolamine-induced neuronal injury by in silico, morphological, biochemical approaches. characterization all was carried out spectroscopically via proton NMR (1H-NMR), FTIR elemental analysis. Further vivo experiments showed that scopolamine...
Background: The purpose of this study was to investigate the suitability nanostructured lipid carriers (NLCs) loaded with miltefosine (HePC) as an anticancer drug for treatment breast cancer. Methods: HePC-NLCs were prepared using a microemulsion technique and then evaluated particle size, polydispersity index (PDI), incorporation efficiency, in vitro release entrapped drug, hemolytic potential. Furthermore, pharmacokinetic, biodistribution, liver toxicity analyses performed Sprague–Dawley...
Rivaroxaban (RXB), a novel Xa inhibitor having groundbreaking therapeutic potential. However, this drug is associated with few limitations, including its pharmacokinetics related toxicities. Here, we developed RXB-loaded SLNs (RXB-SLNs) to improve biopharmaceutical profile. Methods: High pressure homogenizer was used prepare RXB-SLNs, followed by their particle characterization, Transmission electron microscopy (TEM), Dynamic light scattering (DSC), and Powder X-ray diffraction (PXRD)...
Objectives: Several studies demonstrated the antioxidant and anti-inflammatory role of melatonin celecoxib. This study is designed to explore underlying mechanism hepatoprotective effects celecoxib against ethanol-induced hepatotoxicity by morphological, biochemical approaches.Materials methods: Adult male rats were divided into five groups: saline, ethanol, melatonin, administered for 11 consecutive days after ethanol injection. Biochemical analyses performed determination glutathione...
Abstract A series of new isoxazolone ( 3a – d ) and pyrazolone 4a derivatives were synthesized assessed for their antioxidant analgesic activity. Among compounds, 3b 4b having nitro (NO 2 group show high activity at a dose 6 mg/kg. Analgesic was further proceeded to explore the contribution opioidergic mechanisms in mediation effects. Animals administered with naloxone, nonselective opioid inverse agonist, 0.5 The results obtained suggested that effects compounds not reversed by specifying...
Rosa webbiana L. (Rosaceae) is one of the least reported and most understudied members this family. It native to Himalayan regions Pakistan Nepal. The anti-convulsant effect n-hexane extract fruit was investigated in a pentylenetetrazole (PTZ)-induced animal model epilepsy. Male Sprague-Dawley rats were divided into six groups (n = 7) including control, PTZ (40 mg/kg), diazepam (4 mg/kg) (at 50, 150 300 mg/kg). Convulsive behavior observed resultant seizures scored, animals sacrificed their...
Heavy metal pollution has become a global environmental issue. metals are contaminating the agro-soils, growing crops, and vegetables through different agricultural practices. In this study, besides phytoremediation potential of maize, role chromium (Cr) lead (Pb) on crop soil health been investigated. Two maize varieties, Pak-Afgoi Neelem, were grown under varying concentrations Cr (50-300 ppm) Pb (30-300 growth parameters i.e., seed germination, leaf size/number, stem girth, plant height,...
Viburnum foetens is an ethanobotanically important plant species traditionally used as purgative and also have sedative properties. Methanol extract from leaf explants was to determine cytotoxic antibacterial potential of this potent shrub. It observed that cytotoxicity against MCF-7 cell lines gradually increases according concentration used. Further, the methanol crude fractionated on polarity basis each fraction again tested for potential. showed 83% inhibition highest all other...
Isatin, a heterocycle scaffold, is the backbone of many anticancer drugs and has previously been reported to engage multiple cellular targets mechanisms, including angiogenesis, cell cycle, checkpoint pathways kinases. Here, we report that novel isatin derivative, 5i, degrades estrogen receptor alpha (ERα) in estrogen-dependent breast cancer cells. This effect nucleus not reported. Tamoxifen fulvestrant represent standard therapy options estrogen-mediated disease but have their own...
Abstract Background 2-Aminothiazoles are significant class of organic medicinal compounds utilized as starting material for the synthesis diverse range heterocyclic analogues with promising therapeutic roles antibacterial, antifungal, anti-HIV, antioxidant, antitumor, anthelmintic, anti-inflammatory & analgesic agents. Experimental Eight 1a, 2a–2g were synthesized and characterized by FTIR NMR ( 1 H 13 C). Evaluation antibacterial potential against multi-drug resistant clinical isolates...
Epilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures. Currently available antiepileptic drugs have severe side effects and do not offer complete cure. Herbal remedies been used for centuries to treat many neurodegenerative disorders. Otostegia limbata L. belongs the largest medicinally important family Lamiaceae distributed in hilly areas of Pakistan. This study was designed assess antioxidant, anti-inflammatory, anticonvulsant potential O. limbata. The...
Abstract In diabetes, increased accumulation of sorbitol has been associated with diabetic complications through polyol pathway. Aldose reductase (AR) is one the key factors involved in reduction glucose to sorbitol, thereby its inhibition important for management complications. present study, a series seven 4-oxo-2-thioxo-1,3-thiazolidin-3-yl acetamide derivatives 3 ( a–g ) were synthesized by reaction 5-(4-hydroxy-3-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl acetic acid 2a and...
Tamarix is an important genus of Tamarieaceae family, known for its medicinal importance. Its taxonomy tricky, and a few molecular makers are available species identification. The present study was designed to evaluate the genetic diversity among 21 specimens collected from Thal desert, Punjab, Pakistan. Ten Inter-Simple Sequence Repeats (ISSR) six Simple (SSR) markers were used. Results revealed that ISSR produced 131 bands, which 116 polymorphic (88.5%) with mean Polymorphic Information...
Cisplatin resistance is a major concern in ovarian cancer treatment. The aim of this study was to investigate if wedelolactone could perform better resistant cells when used combination with cisplatin.Growth inhibitory potential and cisplatin investigated through MTT reduction assay cell lines including A2780 (sensitive), A2780cisR (cisplatin resistant) A2780ZD0473R. Resistance factor (RF) drugs determined these three lines. Combination index (CI) calculated as measure combined drug action....
Lilium spp. is the most significant decorative plant and has high demand in floriculture market. We studied impact of different growth regulators on culture initiation, shoot proliferation, root formation for disease-free plants from vitro propagation. The explant basal scale was used varying concentrations BAP (6-Benzylaminopurine) alone combination with IAA (Indole-3-acetic acid) showed responses. It observed that MS media supplemented at 1.5 mg/l 1.0 exhibited maximum number shoots, i.e.,...
Cisplatin is a platinum drug in current clinical use for the treatment of cervical cancer. However, toxicity and resistance are its two major limitations. The aim this investigation was to test cytotoxic activity potential phytochemicals alone combination with cisplatin cancer cells.In study, cytotoxicity including wedelolactone (WDL), betulinic acid (BA) epigallocatechin gallate (EGCG) investigated human cell line HeLa through 3-(4, 5-Dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium...
The development of resistance to available anticancer drugs is increasingly becoming a major challenge and new chemical entities could be unveiled compensate this therapeutic failure. current study demonstrated the synthesis 2-aminothiazole [S3(a-d) S5(a-d)] 2-aminopyridine [S4(a-d) S6(a-d)] derivatives that can target multiple cellular networks implicated in cancer development.Biological assays were performed investigate antioxidant potential synthesized compounds. Redox imbalance oxidative...