In search of suitable therapy for the management Alzheimer's disease, this study was designed to evaluate metal complexes against its biochemical targets. Zinc carboxylates (AAZ1–AAZ6) were evaluated acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The antioxidant in combination with anticholinesterase activity can be considered as an important target disease. Therefore, these compounds also screened ABTS DPPH free radical scavenging activity. AChE inhibition assay, we noticed...

Mucopermeating nanoformulations can enhance mucosal penetration of poorly soluble drugs at their target site. In this work, thiolated chitosan (TCS)-lithocholic acid (LA) nanomicelles loaded with β-carotene, a safe phytochemical anticancer properties, were designed to improve the pharmaceutical and pharmacological drug profile. The TCS-LA characterized by FTIR confirm presence thiol group that favors skin adhesion, corroborate conjugation hydrophobic LA hydrophilic CS form an amphiphilic...

Intensive care units (ICUs) are specialized where patients with critical conditions admitted for getting and individualized medical treatment. High mortality rates have been observed in ICUs, but the exact reason factors affecting not yet studied local population Pakistan.This study was aimed to determine rational use of antibiotic therapy ICU its impact on clinical outcomes rate.This a retrospective, longitudinal (cohort) including 100 largest tertiary hospital capital city Pakistan.It that...

Abstract A series of new isoxazolone ( 3a – d ) and pyrazolone 4a derivatives were synthesized assessed for their antioxidant analgesic activity. Among compounds, 3b 4b having nitro (NO 2 group show high activity at a dose 6 mg/kg. Analgesic was further proceeded to explore the contribution opioidergic mechanisms in mediation effects. Animals administered with naloxone, nonselective opioid inverse agonist, 0.5 The results obtained suggested that effects compounds not reversed by specifying...

Purpose: To investigate the antihyperglycemic activity of Conyza canadensis via α-glucosidase inhibition in alloxan-induced diabetic mice.Methods: In vitro antidiabetic was investigated using assay with acarbose (62.5, 125, 500 and 1000 μg/ml) as standard drug. crude extract (Cc.Cr) doses 10, 30, 100 300 mg/kg were administered daily a single dose to alloxaninduced (200 mg/kg) mice (Balb/c), its effect on fasting blood glucose levels body weight evaluated for 15 consecutive days; oral...

Alzheimer's disease (AD) is a neurodegenerative illness described predominantly by dementia. Even though has been known for over century, its origin remains mystery, and researchers are exploring many therapy options, including the cholinesterase technique. A decreased acetylcholine ACh neurotransmitter level believed to be among important factors in progression of disease.In continuation synthesizing potential anti-Alzheimer agents appreciative pharmacological amide-containing compounds,...

With the recent technological advancements, a new golden era of natural products drug discovery has dawned. Increasingly it is being realized that structural modularity many pharmacologically active derived sources allows building-block approach which can be exploited for analysis regulation deregulated oncogenic protein networks in different cancers. Piceatannol been shown to effectively modulate JAK/STAT, Wnt/β-catenin, mTOR pathway In addition, certain hints have emerged shed light on...

Purpose: To investigate the wound-healing potential of herbal formulations (emulgels and in situ gels) containing Saussurea lappa root extract (SLRE) via excision wound induction albino rats.
 Methods: Preliminary phytochemical analysis methanol roots was performed using standard procedures. In vitro anti-inflammatory assay SLRE conducted heat-induced hemolysis method at a concentration 100 μg/mL. Acute toxicity also evaluated mice single dose 1000 mg/kg for 24 h. Emulgels gels were...

In the current study, a series of Schiff base derivatives lamotrigine are complexed with zinc, copper, silver, and tin characterized by spectroscopic techniques biological assays. Docking analyses revealed six complexes favorable binding interactions, which were further subjected to in vitro anticancer activity. The 6b 6c displayed most potent antiproliferative activity against MCF-7 cell lines an IC50 value 11.9 ± 0.27 12.0 0.14 μM, respectively, as compared standard doxorubicin 0.90 μM....

Background: The human lips are the essential structure for speech, facial expression and oral functions like eating, drinking breathing. orthodontic treatment is very crucial advancement of Lip incompetence a condition in which fail to close adequately leading negative effects on esthetics functions. Study design: It retrospective study conducted at WATIM Dental College Rawat, Rawalpindi Altamash Institute Medicine, Karachi duration six months from Jan 2022 June 2022. Material Methods:...

Abstract Three new bioactive metabolites, 1,6-dihydroxy- 2-methyl-heptan-4-one ( 1 ), 4-hydroxy-1-(2-methyl-oxiranyl)- pentan-2-one 2 and 2-(2-hydroxy-propyl)-4-methylfuran- 3-carboxylic acid amide 3 ) were isolated from the terrestrial Streptomyces sp. isolate ANK245, along with microbial constituent p -vinylanisol 4a known metabolites -vinyl-phenol 4b phenethyl alcohol. Analysis of nonpolar part extract by gas chromatography/mass spectrometry (GC-MS) provided further evidence for...

Genetic, genomic and proteomic studies have refined our concepts related to underlying mechanisms of pancreatic cancer. Increasingly sophisticated knowledge has started shed light on the fact that cancer harbored multiple epigenetic genetic alterations revealed complicated dense tumor microenvironments. Our rapidly evolving about helped us in identification myriad which play instrumental role disease onset, drug resistance epithelial mesenchymal transition (EMT). Additionally, loss apoptosis...

Seven brands of ciprofloxacin (One multinational and six local) were evaluated in terms their bioavailability efficacy. Pharmaceutical Parameters like weight variation, hardness, disintegration, dissolution content assay determined. Antibacterial susceptibility was performed on standard Strain <i>Salmonella typhi</i> (ATCC 14028). MIC ZOI assessed. The results the study indicated that three local had less than stated claim USP one brand did not pass disintegration tests, so they cannot be...

Formulations of metronidazole M1, M2, M3, M4, and M5 with the polymer ethyl cellulose M1*, M2*, M3*, M4* M5* Eudragit RS100 at varying concentrations were prepared characterized by Zeta sizer, SEM, DSC, FTIR XRD. The gel was evaluated for its spreadability, skin irritancy, entrapment efficiency drug release. Size in 292.2 nm PDI 1.00 371.8 0.809 observed. production yield observed to be 68.40 % 66.9 respectively. While EE PY M2 66.70 58 did not reveal any incompatibility between drugs SEM...

Purpose: To investigate the possible hepatoprotective potential of Parthenium hysterophorus crude extract (Ph.Cr) against carbon tetrachloride (CCL4)- and paracetamol-induced hepatotoxicity in rabbits.Methods: Twenty rabbits were divided into five groups four each. Group 1 served as normal control received saline (5 mL/kg). 2 followed by CCL4 (0.75 mL/kg p.o dose) after h. Groups 3 4 Ph.Cr at doses 15 30 mg/kg po, respectively, for 7 days one dose CCL4, h last mL/kg, sc). 5 silymarin...