A5081975701- Neuroinflammation and Neurodegeneration Mechanisms
- Synthetic Organic Chemistry Methods
- Pain Mechanisms and Treatments
- Tryptophan and brain disorders
- Marine Sponges and Natural Products
- Wnt/β-catenin signaling in development and cancer
- Coenzyme Q10 studies and effects
- Microbial Natural Products and Biosynthesis
- Eicosanoids and Hypertension Pharmacology
- Bioactive Compounds and Antitumor Agents
- Pharmacological Effects of Natural Compounds
- NF-κB Signaling Pathways
- Cancer-related gene regulation
- Synthesis and Biological Activity
- Endoplasmic Reticulum Stress and Disease
- Traditional and Medicinal Uses of Annonaceae
- Alkaloids: synthesis and pharmacology
- Berberine and alkaloids research
- Stress Responses and Cortisol
- Cancer Mechanisms and Therapy
- Axial and Atropisomeric Chirality Synthesis
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Healthcare and Venom Research
- Peroxisome Proliferator-Activated Receptors
Peking University
2020-2024
Centre for Addiction and Mental Health
2020
Oxidative stress-mediated neuroinflammatory events are the hallmark of neurodegenerative diseases. The current study aimed to synthesize a series novel succinamide derivatives and further investigate neuroprotective potential these compounds against scopolamine-induced neuronal injury by in silico, morphological, biochemical approaches. characterization all was carried out spectroscopically via proton NMR (1H-NMR), FTIR elemental analysis. Further vivo experiments showed that scopolamine...
Stroke is the leading cause of morbidity and mortality worldwide. About 87% stroke cases are ischemic, which disrupt physiological activity brain, thus to a series complex pathophysiological events. Despite decades research on neuroprotectants probe for suitable therapies against ischemic stroke, no successful results have been obtained, new alternative approaches urgently required in order combat this pathological torment. To address these problems, drug repositioning/reprofiling explored...
Oxidative stress-induced neuroinflammation is the prominent feature of neurodegenerative disorders, and characterized by a gradual decline structure function neurons. Many biochemical events emerge thanks to result this neurodegeneration, ultimately provoke neuroinflammation, activation microglia, oxidative stress, leading neuronal death. This cascade not only explains complexity taking place across different stages, but also depicts need for more effective therapeutic agents. The present...
The current study explored the effects of natural compounds, berbamine, bergapten, and carveol on paclitaxel-associated neuroinflammatory pain. Berbamine, an alkaloid obtained from BerberisamurensisRuprhas been previously researched for anticancer anti-inflammatory potential. Bergapten is 5-methoxsalenpsoralen investigated in cancer, vitiligo, psoriasis. Carveol caraway a component essential oil. neuropathic pain model was induced by administering 2 mg/kg paclitaxel (PTX) every other day...
Abstract The first total synthesis of incarnatapeptins A and B, two novel marine natural products, was accomplished from readily available ( S )‐1‐benzyloxycarbonylhexahydropyridazine‐3‐carboxylic acid. This route, whose longest linear sequence 12 steps, provided the B in yields 26.5 % 19.7 %, respectively, enabled structure stereochemistry both products to be unambiguously confirmed. Highlights our include photoredox‐mediated decarboxylative 1,4‐addition reaction a practical N ‐acylation...
Peripheral inflammation leads to the development of persistent thermal hyperalgesia and mechanical allodynia associated with increased expression interleukin-1β (IL-1β) in spinal cord. The aim present study was investigate effects thiazolidine derivatives, 1b ([2-(2-hydroxyphenyl)-1,3-thiazolidin-4-yl](morpholin-4-yl)methanone) 1d (2-hydroxy-4-{[2-(2-hydroxyphenyl)-1,3-thiazolidine-4-carbonyl]amino}benzoic acid), on hyperalgesia, IL-1β during carrageenan-induced cord mice. Inflammatory pain...
Abstract The first total synthesis of incarnatapeptins A and B, two novel marine natural products, was accomplished from readily available ( S )‐1‐benzyloxycarbonylhexahydropyridazine‐3‐carboxylic acid. This route, whose longest linear sequence 12 steps, provided the B in yields 26.5 % 19.7 %, respectively, enabled structure stereochemistry both products to be unambiguously confirmed. Highlights our include photoredox‐mediated decarboxylative 1,4‐addition reaction a practical N ‐acylation...
Total synthesis of the proposed noursamycin A has been accomplished, which disproves original structural assignments. The synthetic strategy described herein also employed in first total nicrophorusamide A, a cyclopeptide that is structurally related to A.
The development of resistance to available anticancer drugs is increasingly becoming a major challenge and new chemical entities could be unveiled compensate for this therapeutic failure.The current study demonstrated whether N-protected deprotected amino acid derivatives 2- aminopyridine attenuate tumor using colorectal cancer cell lines.Biological assays were performed investigate the potential synthesized compounds. in silico ADME profiling docking studies also by designed compounds...