Kazakhstan’s pharmaceutical industry is producing low amount of domestic medicinal products due to insufficient study local plants as a drug source and high demand these in foreign market. In this case, fundamental studies endemic are the highest priority for science pharmacy. Ferula foetida plant that combines various active substances with valuable biological activity. The has massive taproot or carrotshaped roots, 12-15 cm diameter crown. It several pharmacological activities like...

Skin conditions, varying from minor irritations to serious inflammatory and infectious disorders, significantly impact human health quality of life. Traditional herbal medicine has always been a source therapeutic agents for the treatment skin diseases, genus Artemisia become valuable resource due its rich diversity bioactive compounds. This review details historical context antibacterial activities various species used in dermatological therapy. Various have found be effective against...

The medicinal plant Cichorium intybus L. is well known for its therapeutic properties and potential pharmaceutical applications. This study focuses on the analysis of biologically active constituents mineral composition C.intybus L., emphasizing plant’s value. Quantative qualitative analyses main bioactive compounds, including organic acids, flavonoids, polysaccharides, coumarins, tannins vitamin C, were conducted. In addition, macro-microelement content was determined using...

Hydrolates, or floral waters, obtained from herbs are using for various purposes in medicinal and cosmetic industries. Biochemical characterization of many Artemisia species their hydrolates, which has not been described before, is important determining unique properties use as the main component cosmetics. Five including absinthium, serotina, nitrosa, sublessingiana, pauciflora were studied quantitatively qualitatively, content moisture, ash, extractive substances was determined. Moreover,...

In this study, the inhibitory potential of bacterial neuraminidase (NA) was observed on leaves Epimedium koreanum Nakai, which is a popular ingredient in traditional herbal medicine. This study attempted to isolate relevant, responsible metabolites and elucidate their inhibition mechanism. The methanol extraction process yielded eight flavonoids (1–8), compounds 7 8 were new named koreanoside F G, respectively. All (1–8) showed significant NA with IC50 values 0.17–106.3 µM. particular,...

The utilization of a building-block-based molecular network is an efficient approach to investigate the unknown chemical space natural products. However, structure-based automated MS/MS data mining remains challenging. This study introduces building block extractor, user-friendly program that automatically extracts user-defined specified features. In addition characteristic product ions and neutral losses, this integrates abundance sequential loss features as blocks for first time. discovery...

This study aimed to search the α-glucosidase inhibitors from barks part of Artocarpus elasticus. The responsible compounds for inhibition were found out as dihydrobenzoxanthones (1–4) and alkylated flavones (5–6). All showed a significant enzyme toward with IC50s 7.6–25.4 μM. Dihydrobenzoxanthones exhibited competitive α-glucosidase. behaviour was fully characterised by double reciprocal plots, Yang's method, time-dependent experiments. compound 1 manifested reversible simple slow-binding,...

To reveal the vacuum drying mechanism of aqueous extracts and develop processing to provide theoretical guidance for Lonicera japonica Thunb. extracts, effects pressure (10, 15, 20, 25, 30 kPa), temperature (80, 90, 100, 110, 120 °C), material thickness (2, 4 mm) on moisture ratio, rate, temperature, effective diffusivity, activation energy, content distribution moisture, water-solubility, flowability, antioxidant capacity, contents chlorogenic acid galuteolin were investigated. Results...

Ikonnikovia kaufmanniana is an endemic plant of Kazakhstan which phytochemical analysis has not been reported. The present study found out that this species enriched with antioxidant chemicals. Isolation and structural identification processes reveal twelve phenolic compounds (1–12) having dihydroflavanonol, flavonol, isoflavone flavanol skeletons. annotation individual components in the extract was carried by LC-ESI-MS/MS to represent a chemotaxonomic marker target plant. activities all...

Ten new sesquiterpene lactones, carlipsines A–J (1–10), and 12 known analogues (11–22) were isolated from the whole plant of Carpesium lipskyi. Their structures elucidated by using 1D 2D NMR HRESIMS analyses, their absolute configurations confirmed X-ray diffraction studies. All compounds identified as germacranolides with diverse substructural features. Compounds 1–4 are 2,5-hemiacetal-linked germacranolides. 5 6 possess a 1,2-epoxy moiety. 7 8 represent unusual 1,5-hemiacetal-linked 9 10...

Six new diterpenoids, sabiperones A—F (1—6) have been isolated from the aerial part of Juniperus sabina. Their structures were elucidated by spectroscopic methods including 2D NMR techniques. Sabiperone F showed moderate cell growth inhibitory activities against five human cancer lines.

Abstract The effects of ultrasound (US), ultrahigh pressure (UP), cold plasma (CP), and high pulsed electric fields (PEF) pretreatments were evaluated for drying characteristics, bioactive components, pectin properties jujube slices during microwave coupled with vacuum (MPVD). US, CP, PEF reduced time by 18.75%, while UP it 6.25%. Samples treated US showed improved color rehydration (345.11%, 319.24%), SEM revealing larger pores post‐pretreatment. PEF‐treated had highest phenol (16.95 mg...

A new bergenin derivative, 3,11-di-O-galloylbergenin (1) was isolated from the roots of Bergenia crassifolia together with four known related compounds.Their structures were elucidated by spectroscopic and chemical analysis.The galloylbergenin showed a moderate anti-lipid droplet accumulation activity.Bergenia (Saxifragaceae) has been used for treatments bronchitis, gastroenteritis, diarrhea, hemostasia, metrorrhagia in Kazakh traditional medicine. 1The phytochemical constituents including

The aerial part of Artemisia absinthium, collected in Almaty region Kazakhstan, investigated for chemical constituent with sufficiently completed quantitative and qualitative analysis. Biological active constituents such as organic acid (1.08%) flavonoids (0.52%) together the moisture content (7.14%), total ash (6.4%), extractives (12.82%) plant A. absinthium were determined. In was found 8 macro-micro elements, main them K (417.930 μg/ml), Ca (116.0225 Mg (26.2250 Na (15.9825 μg/ml) by...

As a promising source of biologically active substances, the Artemisia species from Kazakhstan have not been investigated efficiently. Considering rich history, medicinal values, and availability plants, systematic investigations two growing in East region were conducted. In this study, one new germacrane-type sesquiterpene lactone (11), together with 10 known sesquiterpenes its dimer, characterized A. nitrosa Weber. Additionally, chromene derivative (1’) another 12 compounds, including...