A5026540507- Drug Transport and Resistance Mechanisms
- Advanced Drug Delivery Systems
- Pancreatic function and diabetes
- Drug Solubulity and Delivery Systems
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Antibiotics Pharmacokinetics and Efficacy
- Renal Transplantation Outcomes and Treatments
- Pregnancy and Medication Impact
- Pharmaceutical studies and practices
- Diabetes and associated disorders
- Probiotics and Fermented Foods
- Computational Drug Discovery Methods
- Diabetes Management and Research
- Drug-Induced Hepatotoxicity and Protection
- Pharmaceutical Economics and Policy
- Diabetes Treatment and Management
- Analytical Chemistry and Chromatography
- Biochemical Analysis and Sensing Techniques
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
University of Novi Sad
2016-2025
University of Banja Luka
2019-2024
Curtin University
2013-2022
Ear Science Institute Australia
2022
Queen Elizabeth II Medical Centre
2022
Institute of Pharmacology
2000-2021
Klinički centar Vojvodine
2003-2021
Military Medical Academy
2018
University of Defence
2018
Innovation Research Center
2017
Natural antioxidant products are increasingly being used to treat various pathological liver conditions considering the role of oxidative stress in their pathogenesis. Rosemary essential oil has already as a preservative food industry due its and antimicrobial activities, but it was shown possess additional health benefits. The aim our study evaluate protective effect rosemary on carbon tetrachloride - induced injury rats explore whether mechanism action is associated with modulation hepatic status.
Silymarin is a complex of five major compounds, and silibinin the most biologically active component complex. The aim this study was to investigate, evaluate confirm potential cardioprotective hepatoprotective effects administration silymarin, rich in silibinin, at dose 60 mg/kg orally for time-span 12 days on doxorubicin induced toxicity male Wistar rats. vivo model used explore whether silymarin could prevent damage liver heart tissue by administered every other day 1.66 intraperitoneally...
Bile acids are naturally produced in humans and known to provide human health benefits through their endocrinological, microfloral, metabolic other åffects that still be elucidated. In recent years, there has been a growing interest using bile as absorption enhancers for drug delivery. amphiphilic molecules with unique ability facilitate promote permeation biological membranes. The role of promoting experimentally illustrated various pharmaceutical formulations including oral, nasal, ocular,...
Introduction: In previous studies, we successfully designed complex multicompartmental microcapsules as a platform for the oral targeted delivery of lipophilic drugs in type 2 diabetes (T2D). Probucol (PB) is an antihyperlipidemic and antioxidant drug with potential to show benefits T2D. We aimed create novel microencapsulated formulation PB examine shape, size, chemical, thermal, rheological properties these vitro. Method: Microencapsulation was carried out using Büchi-based...
In previous studies carried out in our laboratory, a bile acid (BA) formulation exerted hypoglycaemic effect rat model of type-1 diabetes (T1D). When the antidiabetic drug gliclazide (G) was added to acid, it augmented effect. recent study, we designed new gliclazide-cholic (G-CA), with good structural properties, excipient compatibility and exhibits pseudoplastic-thixotropic characteristics. The aim this study is test slow release pH-controlled properties formulation. also examine CA on G...
Major problem for diabetic patients represents damage of blood vessels and the oxidative stress brain cells due to increased concentration free radicals poor nutrition cells. Gliclazide has antioxidative properties barrier (BBB) penetration. Bile acids are known their hypoglycemic effect as promoters drug penetration across biological membranes. Accordingly, aim this study is investigate whether bile acid (deoxycholic acid) can change permeation gliclazide, through a rat model type-1...
Introduction: In previous studies, we have shown that a gliclazide–cholic acid derivative (G–CA) mixture resulted in an enhanced ileal permeation of G (ex vivo). When administered orally to diabetic rats, it brought about significant hypoglycaemic effect. this study, aim create novel microencapsulated-formulation G–CA with uniform and coherent structure can be further tested our rat model type 1 diabetes (T1D). We also examine the effect CA addition microcapsules morphology, excipients'...
Abstract: Gliclazide (G) is an antidiabetic drug commonly used in type 2 diabetes. It has extrapancreatic hypoglycemic effects, which makes it a good candidate 1 diabetes (T1D). In previous studies, we have shown that gliclazide-bile acid mixture exerted effect rat model of T1D. We also gliclazide-deoxycholic (G-DCA) resulted better G permeation vivo, but did not produce effect. this study, aimed to develop novel microencapsulated formulation G-DCA with uniform structure, the potential...
We have demonstrated a permeation-enhancing effect of deoxycholic acid (DCA), the bile acid, in diabetic rats. In this study, we designed DCA-based microcapsules for oral delivery antilipidemic drug probucol (PB), which has potential antidiabetic effects. aimed to further characterize these and examine their pH-dependent release properties, as well effects DCA on stability mechanical strength at various pH temperature values. Using polymer sodium alginate (SA), prepared PB-SA (control)...
Liposomes have been studied as a colloidal carrier in drug delivery systems, especially for oral administration. However, their low structural integrity the gut is still major shortcoming. Membrane disruptive effects of physiological bile salts small intestine result premature release prior to intestinal absorption. Thus, we analyzed stabilizing effect sodium deoxycholate when incorporated into nano-sized liposomes.Cefotaxime-loaded liposomes were prepared with different concentrations...
Abstract The antilipidemic drug, probucol (PB), has demonstrated potential applications in Type 2 diabetes (T2D) through its protective effects on pancreatic β-cells. PB poor solubility and bioavailability, despite attempts to improve oral delivery, none shown dramatic improvements absorption or antidiabetic effects. Preliminary data benefits from bile acid co-encapsulation with PB. One best improvement of delivery (ursodeoxycholic acid, UDCA). This study aimed examine UDCA microcapsules...