A5064158459- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Chemotherapy-induced cardiotoxicity and mitigation
- Hemoglobinopathies and Related Disorders
- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Acute Myeloid Leukemia Research
- Phytochemicals and Antioxidant Activities
- Antifungal resistance and susceptibility
- Hematological disorders and diagnostics
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Healthcare Quality and Management
- AI in Service Interactions
- Lymphoma Diagnosis and Treatment
- Free Radicals and Antioxidants
- Histiocytic Disorders and Treatments
- Medical and Biological Ozone Research
- Tumors and Oncological Cases
- Mycotoxins in Agriculture and Food
- Diet and metabolism studies
- Veterinary Oncology Research
- Neuroblastoma Research and Treatments
- Retinoids in leukemia and cellular processes
- Bioactive Compounds and Antitumor Agents
Institute of Public Health of Vojvodina
2011-2024
University of Novi Sad
2013-2024
Pediatrics and Genetics
2017
Institut za zdravstvenu zaštitu dece i omladine Vojvodine
2010-2016
Klinički centar Vojvodine
1991-2012
Oncology Institute of Vojvodina
2011
Silymarin is a complex of five major compounds, and silibinin the most biologically active component complex. The aim this study was to investigate, evaluate confirm potential cardioprotective hepatoprotective effects administration silymarin, rich in silibinin, at dose 60 mg/kg orally for time-span 12 days on doxorubicin induced toxicity male Wistar rats. vivo model used explore whether silymarin could prevent damage liver heart tissue by administered every other day 1.66 intraperitoneally...
We have examined the influence of diluted pure celery and parsley leaf root juices their combinations with doxorubicin on antioxidant status [as measured by content reduced glutathione (GSH) ferric reducing power (FRAP)] in liver homogenate hemolysate contents cytochrome P450 homogenate. It was found that significantly decreased total antioxidative (FRAP) hemolysate, while alone combination had different actions. Doxorubicin juice no effect P450. However, doxorubicin, significant increased,...
The aim of this work was to investigate possible protective effect celery juice in doxorubicin treatment. following biochemical parameters were determined: content reduced glutathione, activities catalase, xanthine oxidase, glutathione peroxidase, and lipid peroxidation intensity liver homogenate blood hemolysate. We examined influence diluted pure leaves roots juices their combinations with doxorubicine on analyzed parameters. Celery influenced the showed effects when applied doxorubicine.
Treatment of advanced soft tissue sarcoma usually includes dacarbazine (DTIC), an alkylating agent that methylates DNA and is active during all phases the cell cycle. Common side effects DTIC include nausea, vomiting, impaired liver kidney function, myelosuppression, pneumonia. There are no accounts, however, histological hematological changes caused by DTIC. We investigated acute morphological in different organs tumors were a single dose Adult Syrian golden hamsters inoculated with...
Although clinical trials have not been completed, it has already confirmed that mebendazole, a well-known anti-parasitic drug widely used in the tropical areas, inhibits cancer cell growth. Preclinical studies show mebendazole notably impedes growth of malignant and metastatic tumors such as osteosarcoma soft tissue sarcoma, melanoma, carcinoma (lung, colorectal, breast, ovarian, hepatocellular adrenocortical), acute myeloid leukaemia, glioblastoma multiforme meduloblastoma. Mebendazole can...
Anemia represents a significant cause of maternal and perinatal mortality, as well child mortality. The aim the research was to determine serum concentration hepcidin in children aged 6 months 2 years adolescents 11 19 which suffer from iron deficiency anemia compare it with control groups, its connection parameters metabolism.The included 173 examinees, 89 them suffered 84 did not (the latter represented group). Blood samples were collected all study participants. analyzed for complete...
Abstract Background: Anemia is a global public health problem of endemic proportions, especially in women, and with serious consequences. was defined according to the World Health Organization criteria as hemoglobin concentration <130 g/L for men <120 women. The incidence anemia varies between regions, so aim study determine randomly selected sample adult working individuals both sexes, Vojvodina. Methods: included total 6087 subjects (4658 1429 non-pregnant women) aged 18-65 years who...
Introduction. A family of a child with cancer needs continuous help and support from medical other professionals, relatives, friends community at the moment making diagnosis during treatment. The goal this study was to find out most frequent sources individual or based psychological support, reported by parents children suffering malignant diseases. We focused on received within first second year Material Methods. analyzed data obtained questionnaire specially designed for different...
Background and objectives The aim of the present study was to assess effect sociodemographic factors on knowledge, attitudes, motivation potential barriers university students towards blood donation in order more effective promotion. Design cross-sectional conducted 1000 participants (500 non-blood donors—NBD, 276 first time donors—FTBD 224 regular donors—RBD) from 14 faculties University Novi Sad, Serbia. measurement tool used a pretested survey questionnaire that included 22 questions...
Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood. Currently, chance achieving a permanent remission in children with ALL nearly 80% (1). Relapses remain an important factor that influence final outcome (2). Bone marrow site relapse, accounting for up to 75% all relapses. The central nervous system and testicles are usual sites extramedullar relapse (3). Although leukemic infiltration could occur anywhere, it rather uncommon elsewhere. We report 3 cases esophageal...
Abstract Introduction Childhood B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) can be traced back to birth using leukemic clone‐specific immunoglobulin heavy chain ( IGH ) rearrangements, implying prenatal origin of this disease. Methods We retrospectively analyzed neonatal blood spots (Guthrie cards) 24 patients with childhood BCP‐ALL aged 1–9.6 years (median 3.1 years) for the presence clonotypic rearrangements identified in diagnostic bone marrow samples. Based on sequences 2...
Introduction. Biphenotypic acute leukaemia is an uncommon type of whose blasts co-express myeloid and B-or T-lymphoid antigens. Case report. We describe two cases paediatric patients with biphenotypic leukaemia. A four-year-old female patient was found to have B-lymphoid associated antigens in the same blast cells. Cytogenetic analysis showed a Philadelphia (Ph) positivity t (9;22) (q34;q11) rearrangements M.bcr-Abl (p210). She treated combined leukaemia/acute lymphoblastic induction therapy...
Objective The treatment of childhood acute lymphoblastic leukemia (ALL) in Serbia is conducted according to protocol ALL IC BMF-2009. therapy includes the application cytostatic drugs methotrexate and 6-mercaptopurine, drug detoxifying Calcium Folinate. At moment, 80% affected children could be cured with current treatment, but resistance its toxic effects remain serious clinical problems. aim study was investigate influence detoxification agents (Calcium Folinate, silymarin ursodeoxycholic...
Introduction. L-asparaginase (L-ASP) is one of the most effective medications for treatment acute lymphoblastic leukaemia (ALL) in children, and allergic reactions to therapy are considered significant side effects. Objective. The aim this study was determine prevalence type reactions, as well identify potential risk factors development during L-ASP children with ALL. Methods. encompassed 70 patients under 18 years age, who were treated at Institute Child Youth Healthcare Vojvodina, Novi Sad...
We described two cases of infantile hepatic hemangioendothelioma: one with a solitary lesion and the other multicentric lesions. Clinical presentation was no liver symptoms in case 1, hepatomegaly, failure to thrive, palpable abdominal mass 2. Diagnostic imaging revealed single tumor formation 1 multiple nodules Dilemmas related nature were solved by microscopic analysis. The patient clinical appearance successfully operated. lesions tissue showed complete involution after corticotherapy.
Introduction. Langerhans Cell Histiocytosis (LCH) is a rare chronic granulomatous, usually multisystem disease of elusive etiology, with peak incidence in early childhood and slow progressing course. Isolated brain histiocytosis very condition neurological finding does not correlate the extent space-occupying anatomical lesions degenerative changes. Case report. A girl, age 2.5 years was presented diabetes insipidus nearly fatal full spectrum isolated histiocytosis. Brain magnetic resonance...
Introduction: Treatment of acute lymphoblastic leukemia includes the use high doses glucocorticoides (prednisone and dexamethasone), which significantly increase success therapy due to lymphocytolitic effect. The aim: aim study was determine tolerability prednisone dexamethasone in children with structure intensity adverse effects, occurred after application these medicines. Subjects methods: In a prospective study, we analyzed effects suffering treated Institute for Child Youth Health Care...
Background/Aim. Urinary tract infection (UTI) in children with febrile neutropenia (FN) after receiving chemotherapy could be followed by atypical symptoms and signs. The absence of routine urine culture (UC) sampling for analysis lead to undiagnosed disease inadequate treatment these patients. aim the study was indicate importance UC who have developed FN point out most probable causative agents UTI antibiotic sensitivity/resistance isolated strains. Methods. During a five-year observation...
Tumors are rarely diagnosed in newborns. Natural history of such tumors, their type, and response to treatment differ from those seen older children. The etiology is still unclear. In this paper, a retrospective study presented diagnostics management neonatal tumors 2008 2012. Out 518 admissions that period, were 15 patients (2.8%), only 3 them (20.0%) prenatally. teratomas (4), retroperitoneal liver (7). Ten (66.6%) had natural benign tumors. Complete surgical excision was the choice 10...