A5061745434- Connective tissue disorders research
- Protease and Inhibitor Mechanisms
- TGF-β signaling in diseases
- Biochemical and biochemical processes
- Neurological Disease Mechanisms and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Environmental Toxicology and Ecotoxicology
- Nanocomposite Films for Food Packaging
- Medicinal Plants and Neuroprotection
- Ginger and Zingiberaceae research
- Bacterial biofilms and quorum sensing
- Postharvest Quality and Shelf Life Management
- Aluminum toxicity and tolerance in plants and animals
- Computational Drug Discovery Methods
- Rice Cultivation and Yield Improvement
- Fish Biology and Ecology Studies
- Antioxidants, Aging, Portulaca oleracea
- Copper-based nanomaterials and applications
- Algal biology and biofuel production
- Hibiscus Plant Research Studies
- Natural Antidiabetic Agents Studies
- Cell Adhesion Molecules Research
- Seaweed-derived Bioactive Compounds
- Assembly Line Balancing Optimization
- Advanced Drug Delivery Systems
University of Tabuk
2021-2024
Qassim University
2024
University of Jeddah
2024
Zagazig University
2024
Wellcome Centre for Cell-Matrix Research
2019-2022
University of Manchester
2019-2022
Manchester Academic Health Science Centre
2019-2022
Background: Pseudomonas aeruginosa is incriminated in septicemia, significant economic losses the poultry production sector, and severe respiratory infections humans. This study aimed to investigate occurrence, opr L sequencing, antimicrobial resistance patterns, virulence-determinant, Quorum sensing, antibiotic genes of P. retrieved from broiler chickens. Methods: Two hundred samples were collected 120 chickens farms at Ismailia Governorate, Egypt. Consequently, bacteriological examination...
Wilson's disease causes copper accumulation in the liver and extrahepatic organs. The available therapies aim to lower levels by various means. However, a potent drug that can repair damaged brain tissue is needed. Silymarin has hepatoprotective, antioxidant, cytoprotective properties. poor oral bioavailability reduces its efficacy. In this study, "thin film hydration method" was used for synthesizing silymarin-encapsulated liposome nanoparticles (SLNPs) evaluated them against toxicity,...
The beneficial microorganisms represent a new and hopeful solution for sustainable environment development. In this investigation, Trichoderma asperellum ZNW, isolated from seeds, was domiciliated within the pea plant improving growth, disease management, enhancement of productivity. Globisporangium ultimum NZW deformed representing first record pathogen caused by damping-off. Both fungi were molecularly identified. T. ZNW produced several lytic enzymes bioactive metabolites as detected...
A natural bioactive compound chamuangone extracted from Thai salad Garcinia cowa leaves exhibited robust medicinal properties, targeting central oxidative stress pathways, and having neuroprotective potential. Chamuangone-enriched rice bran oil (CERBO), with 1.97 mg/mL chamuangone, was obtained through green extraction. The study designed to evaluate the anti-Parkinson’s activity of CERBO in haloperidol- induced Parkinsonian rat model. Animals were categorized into six groups as control,...
TGFβ superfamily members are potent growth factors in the extracellular matrix with essential roles all aspects of cellular behaviour. Latent binding proteins (LTBPs) co-expressed TGFβ, for correct folding and secretion factor, to form large latent complexes. These complexes bind such as fibrillin sequestration matrix, normal tissue function, dysregulated signalling is a hallmark many fibrillinopathies. Transglutaminase-2 (TG2) cross-linking LTBPs known play role activation but underlying...
The search for a natural antimicrobial agent is ongoing and critical because of the rise rapid proliferation antibiotic-resistant pathogenic bacteria. current study aims to examine effect Paenibacillus polymyxa AM20 as an alternative antibiotic feed additive on Indian river broiler performance, digestive enzymes, thyroid hormones, lipid profile, hepatosomatic index, immunological response, gut bacteria, antioxidant parameters. bacterial isolate was identified at gene level by isolating DNA...
Aloe barbadensis is a stemless plant with length of 60-100 cm juicy leaves which used for its remedial and healing properties in different suburbs various countries. The present study was conducted to investigate the effect A. leaf extract (aqueous ethanolic) yeast induced pyrexia acetic acid writhing rat model evaluate antipyretic biomarkers phytochemical screening computational analysis. For analgesic activity 60 Albino rats (160-200 kg) were divided into four groups. Of 4 groups, control...
Diabesity is the concurrence of both diabetes and obesity, it has become a modern epidemic. It linked by numerous common pathophysiological mechanisms which can be targeted to combat its harms. The available treatments for diabesity include medications that are also causing several adverse side effects. increasing healthcare costs, direct indirect, management continue rise, underscoring urgency find efficient cost-effective treatment methods. These circumstances have prompted shift in...
This work investigated the antioxidant and hepatoprotective activities of lemongrass extract its effects on rat hepatotoxicity. The (LGE) contains bioactive components such as phenolic acids, flavonoid components, vitamin C, fibers, tannins. LGE had high content (397 mg/100g) flavonoids (164 mg/100g), influencing activity 91.25%. Additionally, it inhibited 81% breast cancer, also, growth pathogenic bacteria Candida at a concentration 20-40 µg/mL. SARS-Cov-2 by 75%; however, increasing Cas-3....
Chamuangone is an exotic medicinal compound isolated from Garcinia cowa leaves. It shows great potential against inflammation, neurodegeneration, and oxidation. Through green extraction method, chamuangone-rich rice bran oil (CRBO) containing 1.97 mg/mL of chamuangone was obtained. This research study investigates the therapeutic effects CRBO on D-galactose- aluminum chloride (AlCl3)-induced Alzheimer’s disease in rat model. In all, 30 rats were divided into six groups treated for 42 days as...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with unmet medical need, and the leading cause of age-related dementia affecting millions people worldwide. This work aims at developing small, high-drug loading capacity (DL) -entrapment efficiency (EE) memantine hydrochloride (MEM)/chitosan nanocrystals (CS-NCs) to treat moderate severe associated AD. MEM-loaded chitosan (MEM/CS-NCs, further abbreviated as MEM-NCs) were prepared by ionic gelation method. Different...
A topological index (TI) is a numerical descriptor of molecule structure or graph that predicts its different physical, biological, and chemical properties in theoretical way avoiding the difficult costly procedures labs. In this paper, for two connected (molecular) graphs <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <msub> <mrow> <mi>G</mi> </mrow> <mn>1</mn> </msub> </math> id="M2"> <mn>2</mn> , we define generalized total-sum consisting various polygonal chains by...
This study showcases a promising approach to sustainably unlocking plant biomass residues by combining biodegradation with artificial intelligence optimize the process. Specifically, we utilized definitive screening design (DSD) and neural networks (ANNs) degradation of common bean endophytic fungus Trichoderma asperellum WNZ-21. The optimized process yielded fungal hydrolysate rich in 12 essential non-essential amino acids, totaling 18,298.14 μg/g biomass. GC-MS analysis revealed four...
This research was designed to assess the toxicity of cadmium (Cd), and its effects on catalase (CAT) activity, histology gills geno-toxicity Oreochromis niloticus. The acute Cd (96-h) for fish computed as 56.021 mg/L (LC50) 80.7336 (LC100) using Probit method. inferences showed that level significantly (P<0.05) lower in treated O. niloticus compared control metal-stress free. It followed order as: intestine<gills<muscles<brain. Results Cd-exposure caused prominent damage both...
Abstract The risks and challenges of the NEOM project on water bodies can be somehow resolved by using Cystoseria sp., a brown-green macroalga, natural renewable resource species, which are appealing due to their sustainability, cost-effectiveness, eco-friendliness. Lipid was extracted from sp. collected Sharma beach, Neom, Tabuk, Kingdom Saudi Arabia. It treated with different solvents, petroleum ether, methanol, ether:methanol (1:1), obtain biofuel. Petroleum ether methanol were most...
Latent TGFβ binding protein-4 (LTBP4) is a multi-domain glycoprotein, essential for regulating the extracellular bioavailability of and assembly elastic fibre proteins, fibrillin-1 tropoelastin. LTBP4 mutations are linked to autosomal recessive cutis laxa type 1C (ARCL1C), rare congenital disease characterised by high mortality severely disrupted connective tissues. Despite importance LTBP4, structure molecular consequences unknown. Therefore, we analysed structural functional three ARCL1C...