A5018428083- Dental materials and restorations
- Antibiotic Resistance in Bacteria
- Scientific and Engineering Research Topics
- Oral microbiology and periodontitis research
- Bone Tissue Engineering Materials
- Dental Health and Care Utilization
- Dental Erosion and Treatment
- Nanoparticles: synthesis and applications
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Nanomaterials in Catalysis
- Lung Cancer Treatments and Mutations
- Computational Drug Discovery Methods
- Aluminum toxicity and tolerance in plants and animals
- Bacterial biofilms and quorum sensing
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Periodontal Regeneration and Treatments
- Berberine and alkaloids research
- Metal complexes synthesis and properties
- Synthesis and Characterization of Heterocyclic Compounds
- Free Radicals and Antioxidants
- Drug-Induced Hepatotoxicity and Protection
- Electrospun Nanofibers in Biomedical Applications
- Colorectal Cancer Treatments and Studies
- Dental Research and COVID-19
National University of Sciences and Technology
2022-2024
Metallic nanoparticles, such as gold nanoparticles (AuNPs), have been extensively studied drug delivery systems for various therapeutic applications. However, drug-loaded-AuNPs rarely explored in vivo their effect on bacteria residing inside tissues. Ciprofloxacin (CIP) is a second-generation fluoroquinolone with broad-spectrum of antibiotic properties devoid developing resistance. This research focused the synthesis and physical characterization Ciprofloxacin-loaded (CIP-AuNPs) colonization...
Resin composites have been widely used in dental restoration. However, polymerization shrinkage and resultant bacterial microleakage are major limitations that may lead to secondary caries. To overcome this, a new type of antibacterial resin composite containing ciprofloxacin-loaded silver nanoparticles (CIP-AgNPs) were synthesized. The chemical reduction approach successfully produced CIP-AgNPs, as demonstrated by FTIR, zeta potential, scanning electron microscopy, ultraviolet-visible...
Antibacterial restorative materials against caries-causing bacteria are highly preferred among high-risk patients, such as the elderly, and patients with metabolic diseases diabetes. This study aimed to enhance antibacterial potential of resin composite Magnesium-doped Zinc oxide (Mg-doped ZnO) nanoparticles (NPs) look for their effectiveness in alloxan-induced diabetic model. Hexagonal Mg-doped ZnO NPs (22.3 nm diameter) were synthesized by co-precipitation method characterized through...
Wilson's disease causes copper accumulation in the liver and extrahepatic organs. The available therapies aim to lower levels by various means. However, a potent drug that can repair damaged brain tissue is needed. Silymarin has hepatoprotective, antioxidant, cytoprotective properties. poor oral bioavailability reduces its efficacy. In this study, "thin film hydration method" was used for synthesizing silymarin-encapsulated liposome nanoparticles (SLNPs) evaluated them against toxicity,...
Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium that present commonly in soil and water responsible for causing septic shock, pneumonia, urinary tract gastrointestinal infections, etc. The multi-drug resistance (MDR) phenomenon has increased dramatically past years now considered major threat globally, so there an urgent need to develop new strategies overcome drug by P. aeruginosa. In aeruginosa, factor of associated the formation biofilms LasR enzyme, which regulates quorum...
Multidrug resistance (MDR) has been a potentiator for the exploration of antibiotics. Nano drug delivery systems have opened new avenues to overcome this challenge. Although antibacterial nanocarriers are extensively realized, their effect on bacteria residing inside tissues and toxicity is rarely explored. This study investigated effects flavonoid coated gold nanoparticles (FAuNPs) colonization Enterococcus faecalis in mouse liver kidneys. Flavonoids were extracted from leaves Berberis...
Biofilm formation in the resin-composite interface is a major challenge for resin-based dental composites. Using doped z nanoparticles (NPs) to enhance antibacterial properties of resin composites can be an effective approach prevent this. The present study focused on effectiveness Selenium-doped ZnO (Se/ZnO) NPs as nanofiller and their impact mechanical properties. Pristine Se/ZnO were synthesized by mechanochemical method confirmed through UV-Vis Spectroscopy, FTIR (Fourier Transform...
Micro-crack formation and resultant bacterial infiltration are major causes of secondary caries in dental resin-based composite restorations. Improving resin composites’ mechanical biological properties using highly bendable nanoparticles (NPs) can resolve this issue. This study aims to develop novel Diethylaminoethyl (DEAE)-Dextran silver (AgNPs) subsequently modify resins with these NPs enhance their antibacterial properties. DEAE-Dextran AgNPs were successfully synthesized a chemical...
Typhoid fever, caused by Salmonella enterica serovar typhi , presents a substantial global health threat, particularly in regions with limited healthcare infrastructure. The rise of multidrug-resistant strains S. exacerbates this challenge, severely compromising conventional treatment efficacy due to over activity efflux pumps. In our study, comprehensive exploration two fundamental aspects combat MDR is carried out; i.e. employing advanced bioinformatics analyses and AlphaFold AI, We...
Plant phytochemicals have potential decontaminating properties, however, their role in the amelioration of hydrophobic water filtration membranes not been elucidated yet. In this work, (i.e., cannabinoids (C) and terpenes (T) from C. sativa) were revealed for antibacterial activity against different Gram-positive Gram-negative bacteria. As such, a synergistic relationship was observed between two all strains. These individually combination used to prepare polyethersulfone (PES) hybrid...
Doped Zinc oxide (ZnO) Nanoparticles (NPs) have been widely studied in a variety of diagnostic and therapeutic applications. However, transition metal doped ZnO NPs rarely explored as an antibacterial agent dental restorative materials. This study aimed to synthesize characterize with metals i.e. Copper (Cu) Silver (Ag) enhancement resin composite these evaluate their mechanical properties. Cu/ZnO Ag/ZnO 23.6 20.5 nm respectively, were successfully prepared by coprecipitation method,...
Synthetic periodontal membranes have appeared as a promising treatment modality for disease. They provide suitable site attachment and growth environment cells exhibit high biocompatibility water retaining capacity. However, existing can develop biofilms induce inflammation at the pocket gingival cells, hence limiting their effectiveness. A Polycaprolactone/sodium alginate-based core-shell membrane with Magnesium doped Zinc oxide (PCL/SA/MgZnO) nanoparticles (NPs) was developed, initial...