A5015254340- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Research in Social Sciences
- Ubiquitin and proteasome pathways
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Disease and Adiposity
- Thermoregulation and physiological responses
- Neurological disorders and treatments
- Colorectal Cancer Screening and Detection
- Molecular Biology Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Urologic and reproductive health conditions
- Hemodynamic Monitoring and Therapy
- Nursing Roles and Practices
- Advanced MRI Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Restless Legs Syndrome Research
- Urological Disorders and Treatments
University of Helsinki
2008-2024
Helsinki University Hospital
2017-2024
University College London
2023
Whipps Cross University Hospital
2023
Barts Health NHS Trust
2023
Royal Free London NHS Foundation Trust
2023
Royal London Hospital
2023
Aava Medical Centre
2021
Imaging Center
2021
Ministry for Foreign Affairs of Finland
2008
Background High variability in prostate MRI quality might reduce accuracy cancer detection. Purpose To prospectively evaluate the of scanners taking part control phase global PRIME (Prostate Imaging Using ± Contrast Enhancement) trial using Prostate Quality (PI-QUAL) standardized scoring system, give recommendations on how to improve protocols, and establish whether could be improved by these recommendations. Materials Methods In prospective clinical (PRIME), for each scanner, centers...
Importance Magnetic Resonance Imaging (MRI) coupled with Prostate Imaging-Reporting and Data System (PI-RADS) provides a standardized scoring system for assessing clinical significance of prostate cancer (PCa). However, the association between PI-RADS scores key end-points remains underexplored due to limited follow-up data. Objective To evaluate cancer-specific mortality (PCSM), overall survival (OS), metastasis-free (MFS), biochemical recurrence (BCR) across multiple cohorts. Design,...
Abstract Background Continuous levodopa‐carbidopa intestinal gel ( LCIG ) diminishes daily “off” time and dyskinesia in patients with advanced Parkinson′s disease PD ). Complications are common percutaneous endoscopic gastrostomy a jejunal extension tube PEG ‐J). Aim of the Study To report clinical outcome years 2006–2014 at Helsinki University Hospital. Patients Methods Levodopa‐carbidopa treatment started following ‐J placement after successful in‐hospital trial nasojejunal tube....
Abstract Magnetic resonance imaging (MRI) is increasingly used to triage patients for prostate biopsy. However, 9% 24% of clinically significant (cs) cancers (PCas) are not visible in MRI. We aimed identify histomic and transcriptomic determinants MRI visibility their association metastasis, PCa‐specific death (PCSD). studied 45 radical prostatectomy‐treated with csPCa (grade group [GG]2‐3), including 30 MRI‐visible 15 MRI‐invisible lesions, 18 men without PCa. First, histological...
Abstract Background: We compare the risk of clinically significant (csPCa; ISUP Grade Group ≥ 2) and insignificant prostate cancer (isPCa; 1) in men with a non-suspicious MRI (nMRI; PI-RADS ≤ general population, assess value PSA density (PSAD) stratification. Methods: In this retrospective population-based cohort study we identified 1,682 50–79-year-old men, who underwent nMRI at HUS (2016–2019). compared their age-standardized incidence rates (IRs) csPCa odds isPCa to local age- sex-matched...
Introduction This study was conducted to describe the changes in repeat multiparametric MRI (mpMRI) occurring prostate cancer (PCa) patients during active surveillance (AS), and possible associations between mpMRI-related parameters predicting biopsy (Bx) Gleason score (GS) upgrading >3+3 protocol-based treatment change (TC). Materials methods The cohort consisted of 76 AS with GS 3+3 PCa at least two consecutive mpMRIs performed 2006–2015. Patients were followed according Prostate Cancer...
To evaluate the feasibility of a population-based screening trial using prostate-specific antigen (PSA), kallikrein panel and multiparametric magnetic resonance imaging (MRI) aimed at minimizing overdiagnosis, while retaining mortality benefit.Feasibility algorithm was evaluated in terms participation, test results cancer detection. A random sample 400 men aged 65 years identified from population registry invited for with three stepwise tests (PSA, MRI). Men PSA levels ≥3 ng/mL were further...
Abstract: Bathing in sauna is common Finland, where there are approximately 2 million saunas among the population of 5.2 million. In this paper, deaths occurring while a 1990–2002 Finland were studied by analyzing police and forensic autopsy reports, death certificates, toxicological results. The annual rate was less than per 100,000 inhabitants. Close to half (51%) cases determined be natural exposure heat cause 25%. Overall, 50% all under influence alcohol. main conclusion that rare event...
The aim of this study is to investigate the potential impact prostate magnetic resonance imaging (MRI) -related interreader variability on a population-based randomized cancer screening trial (ProScreen). From January 2014 2018, 100 men aged 50-63 years with clinical suspicion (PCa) in Helsinki University Hospital underwent MRI. Nine radiologists individually reviewed pseudonymized MRI scans all two ProScreen centers. All were biopsied according histological composite variable comprising...
Background To determine the added value of preoperative prostate multiparametric MRI (mpMRI) supplementary to clinical variables and their role in predicting post prostatectomy adverse findings biochemically recurrent cancer (BCR). Methods All consecutive patients treated at HUS Helsinki University Hospital with robot assisted radical (RALP) between 2014 2015 were included analysis. The mpMRI data, variables, histopathological characteristics, follow-up information collected. Study...
Some clinically significant prostate cancers are missed by MRI. We asked whether the tumor stroma in surgically treated localized cancer lesions positive or negative with MRI different their cellular and molecular properties, differences reflected to clinical course of disease. profiled stromal immune cell composition MRI-classified applying multiplexed fluorescence IHC (mfIHC) automated image analysis a cohort 343 patients (cohort I). compared variables between MRI-visible lesions,...
<p>Supplementary Table S2. Baseline characteristics and follow-up details. A table listing baseline characteristic details for the participants of each study cohort.</p>
<p>MRI specifications. A table listing the MRI sequence parameters used by two scanners in study. Images were obtained with phased-array coil and without endorectal coil.</p>
<p>Supplementary Figure S1. Formula used for calculating follow-up time the general population. The Supplementary S1 illustrates process of to calculate men in population cohort at age Y. Population data (A and B) are sourced from Statistics Finland (RRID:SCR_024843) prostate cancer (PCa) is based on institutional pathology data. This calculation was repeated all ages (50-79 years).</p>
<p>Supplementary Figure S1. Formula used for calculating follow-up time the general population. The Supplementary S1 illustrates process of to calculate men in population cohort at age Y. Population data (A and B) are sourced from Statistics Finland (RRID:SCR_024843) prostate cancer (PCa) is based on institutional pathology data. This calculation was repeated all ages (50-79 years).</p>
<p>Supplementary Table S2. Baseline characteristics and follow-up details. A table listing baseline characteristic details for the participants of each study cohort.</p>
<p>MRI specifications. A table listing the MRI sequence parameters used by two scanners in study. Images were obtained with phased-array coil and without endorectal coil.</p>
<div>AbstractBackground:<p>We compare the risk of clinically significant (csPCa; ISUP Grade Group ≥ 2) and insignificant prostate cancer (isPCa; 1) in men with a nonsuspicious MRI (nMRI; PI-RADS ≤ general population, assess value PSA density (PSAD) stratification.</p>Methods:<p>In this retrospective population-based cohort study we identified 1,682 50–79-year-old men, who underwent nMRI at HUS (2016–2019). We compared their age-standardized incidence rates (IR) csPCa...
<div>AbstractBackground:<p>We compare the risk of clinically significant (csPCa; ISUP Grade Group ≥ 2) and insignificant prostate cancer (isPCa; 1) in men with a nonsuspicious MRI (nMRI; PI-RADS ≤ general population, assess value PSA density (PSAD) stratification.</p>Methods:<p>In this retrospective population-based cohort study we identified 1,682 50–79-year-old men, who underwent nMRI at HUS (2016–2019). We compared their age-standardized incidence rates (IR) csPCa...