A5084619760- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Ureteral procedures and complications
- Pediatric Urology and Nephrology Studies
- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Diversity and Career in Medicine
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Global Health Workforce Issues
- Nursing Roles and Practices
- Primary Care and Health Outcomes
- Healthcare Policy and Management
- Urologic and reproductive health conditions
- Nursing Education, Practice, and Leadership
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Renal cell carcinoma treatment
- Healthcare Systems and Challenges
- Cardiovascular and Diving-Related Complications
- Geriatric Care and Nursing Homes
- Testicular diseases and treatments
- Healthcare Quality and Management
- Cell Adhesion Molecules Research
James Cook University Hospital
2009-2023
South Tees Hospitals NHS Foundation Trust
2016-2023
British Association of Urological Surgeons
2020
University College London
2018
University College Hospital
2018
Stoke Mandeville Spinal Research
2018
John Wiley & Sons (United Kingdom)
2018
Cheltenham Festivals
2018
London Cancer
2018
Royal Surrey County Hospital
2018
Adjuvant intravesical chemotherapy following tumour resection is recommended for intermediate-risk non-muscle-invasive bladder cancer (NMIBC).To assess the efficacy and safety of adjuvant chemohyperthermia (CHT) NMIBC.HIVEC-II an open-label, phase 2 randomised controlled trial CHT versus alone in patients with NMIBC recruited at 15 centres between May 2014 December 2017 (ISRCTN 23639415). Randomisation was stratified by treating hospital.Patients were randomly assigned (1:1) to mitomycin C...
Computerized tomography urogram is recommended when investigating patients with hematuria. We determined the incidence of urinary tract cancer and compared diagnostic accuracy computerized to that renal bladder ultrasound for identifying cancer.The DETECT (Detecting Bladder Cancer Using UroMark Test) I study a prospective observational recruiting 18 years old or older following presentation macroscopic microscopic hematuria at total 40 hospitals. All underwent cystoscopy upper imaging...
BACKGROUND: Recurrence of non–muscle-invasive bladder cancer (NMIBC) is common after transurethral resection tumor (TURBT). Photodynamic diagnosis (PDD) provides better diagnostic accuracy and more complete may reduce recurrence. However, there limited evidence on the longer-term clinical effectiveness cost-effectiveness PDD-guided resection. METHODS: In this pragmatic, open-label, parallel-group randomized trial conducted in 22 U.K. National Health Service hospitals, we recruited...
We report NHS England data for patients with bladder cancer (BC), upper tract urothelial (UTUC: renal pelvic and ureteric), urethral cancers from 2013 to 2019.
Objectives To evaluate the activity of intravesical mitomycin‐C (MMC) to ablate recurrent low‐risk non‐muscle‐invasive bladder cancer (NMIBC) and assess whether it may enable patients avoid surgical intervention for treatment recurrence. Patients Methods CALIBER is a phase II feasibility study. Participants were randomized (2:1) with four once‐weekly MMC 40‐mg instillations (chemoablation arm) or management. The group was included randomization. primary endpoint complete response in...
OBJECTIVE To present the early results of use third‐generation cryotherapy in primary and recurrent prostate cancer at one UK centre. PATIENTS AND METHODS Over a 14‐month period 51 patients underwent for cancer. In 31 was used as treatment 20 salvage after radiotherapy or hormone ablation. Data were collected prospectively median follow‐up 9 months. RESULTS The prostate‐specific antigen (PSA) level decreased to <0.5 ng/mL 79% undergoing 67% treatment. A higher Gleason grade PSA levels...
Objectives To determine the diagnostic accuracy of urinary cytology to diagnose bladder cancer and upper tract urothelial ( UTUC ) as well outcome patients with a positive urine normal haematuria investigations in multicentre prospective observational study investigated for haematuria. Patient methods The DETECT I (clinicaltrials.gov NCT 02676180) recruited presenting following referral secondary case at 40 hospitals. All had cystoscopy imaging (renal ultrasound [ RBUS ] and/ or CT urogram...
The main objective of this study was to evaluate the various instruments available quality life (QoL) in patients diagnosed with non-muscle invasive bladder cancer (NMIBC) undergoing surveillance.A PubMed literature review carried out query terms ("Urinary Bladder Neoplasms" [Mesh] OR "Bladder malignancy") AND ("quality life") including all studies up June 2020. This resulted 576 peer-reviewed articles. A further 12 articles from additional sources were included. total 473 eliminated due...
To present our 15-year experience of laparoscopic retroperitoneal lymph node dissection (LRPLND) combined with adjuvant chemotherapy (after RPLND) for patients nonseminomatous germ cell tumour and positive nodes (pN+), evaluating the morbidity long-term oncological outcome.Data 87 clinical stage I GCT were collected prospectively from 1992 to 2007. Primary diagnostic LRPLND was performed pathological staging using a modified-template dissection. Patients involvement had chemotherapy, two...
Objective To establish the current standard for open radical cystectomy (ORC) in England, as data entry by surgeons performing RC to British Association of Urological Surgeons (BAUS) database was mandated 2013 and combining this with Hospital Episodes Statistics (HES) has allowed comprehensive outcome analysis first time. Patients Methods All patients were included if they uploaded BAUS registry reported have been performed 2 years between 1 January 2014 31 December 2015 England (from...
Abstract Background A lack of consensus exists amongst national guidelines regarding who should be investigated for haematuria. Type haematuria and age‐specific thresholds are frequently used to guide referral the investigation Objectives To develop externally validate cancer risk score (HCRS) improve patient selection Methods Development cohort comprise 3539 prospectively recruited patients at 40 UK hospitals (DETECT 1; ClinicalTrials.gov: NCT02676180) validation 656 Swiss patients. All...
Background Around 7500 people are diagnosed with non-muscle-invasive bladder cancer in the UK annually. Recurrence following transurethral resection of tumour is common, and intensive monitoring schedule required after initial treatment has associated costs for patients NHS. In photodynamic diagnosis, before tumour, a photosensitiser that preferentially absorbed by cells instilled intravesically. Transurethral then conducted under blue light, causing to fluoresce. Photodynamic...
Pancreatic cancer is an aggressive and potent disease, which largely resistant to conventional forms of treatment. However, the discovery antigens associated with pancreatic cells has recently suggested possibility that immunotherapy might become a specific effective therapeutic option. T within many epithelia, including those pancreas, are known express αEβ7-integrin adhesion molecule, CD103. The only characterised ligand for CD103 E-cadherin, epithelial molecule exhibits reduced expression...
Summary The primary aim of this work was to survey normal urothelium and transitional cell carcinoma (TCC) for the presence T lymphocytes expressing intraepithelial, CD103+ phenotype. This antigen defines αEβ7-integrin. adhesive counter-receptor αEβ7 is E-cadherin, which down-regulated during cancer progression. secondary determine pattern distribution in relation E-cadherin expression bladder cancer. Cryostat sections TCC were treated with antibodies specific human CD103, CD3, CD8...
Objective: To analyse the British Association of Urological Surgeons’ (BAUS) radical cystectomy (RC) dataset, to examine trends in patient selection, use neoadjuvant chemotherapy (NAC) and operative technique. Methods: Data for RC were entered into a database voluntarily, by operating surgeons. A comparison was made Hospital Episode Statistics (HES) data, estimate proportion cases captured dataset. Results: From 2004 2012, data collected on 5321 patients undergoing RC. This constituted 37.1%...
Objectives This study aims to track electroconvulsive therapy (ECT) clinics' compliance with standards for the administration of ECT before and after introduction Electroconvulsive Therapy Accreditation Service (ECTAS) in 2003. Methods Three audits on practice were retrospectively analyzed, ECTAS data from 2004 2011 prospectively analyzed. Overall 10 audit was presented 2 ways: annually each 3 waves accreditation. Results There have been continuing improvements since accreditation service...