A5024405019- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Radiopharmaceutical Chemistry and Applications
- Genetic factors in colorectal cancer
- Epilepsy research and treatment
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Effects and Toxicity Studies
- Chemical Reactions and Isotopes
- Intimate Partner and Family Violence
- Glioma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Homicide, Infanticide, and Child Abuse
- RNA Interference and Gene Delivery
- Global Peace and Security Dynamics
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- RNA modifications and cancer
- Cancer therapeutics and mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cancer Treatment and Pharmacology
- Cell death mechanisms and regulation
Cancer Research UK
2024
Emerald Group Publishing (United Kingdom)
2021-2023
University of Alabama at Birmingham
2023
Dayton Children's Hospital
2023
University of Manchester
2010-2021
MIT University
2018-2021
RMIT University
2018-2021
Goldsmiths University of London
2018-2021
Institute for Employment Studies
2021
Addenbrooke's Hospital
2018
Chronic systemic inflammatory conditions, such as atherosclerosis, diabetes and obesity are associated with increased risk of stroke, which suggests that inflammation may contribute to the development stroke in humans. The hypothesis induce brain pathology can be tested animals, this was key objective present study. First, we assessed changes rodent models chronic, inflammation. PET imaging revealed microglia activation JCR-LA (corpulent) rats, develop atherosclerosis obesity, compared...
Pathologic deposition of amyloid β (Aβ) protein is a key component in the pathogenesis Alzheimer disease (AD) but not feature frontotemporal dementia (FTD). PET ligands for Aβ are increasingly used diagnosis and research syndromes. Here, we report study using <sup>18</sup>F-florbetapir healthy controls patients with AD FTD. <b>Methods:</b> Ten (mean age ± SD, 62.5 5.2 y), 10 62.6 4.5), 8 FTD 9.6) were recruited to study. All underwent detailed clinical neuropsychologic assessment T1-weighted...
Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor in demand; acquisition longitudinal biopsies is a significant challenge minimally invasive required. Considering this, we validated preclinical 'death-switch' model for discovery secreted tumour using vitro proteomics vivo evaluation novel imaging probe [18F]ML-10 non-invasive detection positron...
(±)4-Fluoro-DPD completely inhibited bioluminescence and bacterial growth of <italic>Vibrio harveyi</italic> BB170 strain by disruption quorum sensing cascade.
PURPOSE: To evaluate the effect of N-phosphonacetyl-l-aspartate (PALA), folinic acid (FA), and interferon alfa (IFN-α) biomodulation on plasma fluorouracil (5FU) pharmacokinetics tumor liver radioactivity uptake retention after [ 18 F]-fluorouracil (5-[ F]-FU) administration. PATIENTS AND METHODS: Twenty-one paired pharmacokinetic studies were completed patients with colorectal, gastric, hepatocellular cancer, utilizing positron emission tomography (PET), which allowed acquisition tumor,...
Abstract Objective Overexpression of the drug transporter P‐glycoprotein (P‐gp) is thought to be involved in drug‐resistance epilepsy by extrusion antiepileptic drugs (AEDs). We used positron emission tomography (PET) and P‐gp substrate radiotracer (R)‐[ 11 C]verapamil (VPM) together with third‐generation inhibitor tariquidar (TQD) evaluate function individuals drug‐resistant epileptogenic developmental lesions. Methods Twelve healthy controls (7 male, median age 45, range 35‐55 years), two...
Abstract The phosphoinositide 3-kinase (PI3K) pathway is deregulated in a range of cancers, and several targeted inhibitors are entering the clinic. This study aimed to investigate whether positron emission tomography tracer 3′-deoxy-3′-[18F]fluorothymidine ([18F]-FLT) suitable mark effect novel PI3K inhibitor GDC-0941, which has entered phase II clinical trial. CBA nude mice bearing U87 glioma HCT116 colorectal xenografts were imaged at baseline with [18F]-FLT acute (18 hours) chronic (186...
Antisense oligonucleotides (ASOs) have potential as anti-cancer agents by specifically modulating genes involved in tumorigenesis. However, little is known about ASO biodistribution and tissue pharmacokinetics (PKs) humans, including whether sufficient delivery to target tumor may be achieved. In this preliminary study human subjects, we used combined positron emission computed tomography (PET-CT) imaging subsequent modeling analysis of acquired dynamic data, examine the vivo PK properties...
Prenylated sequences unlocks the development of new therapeutics as demonstrated for an anticancer agent.
Meta-iodobenzylguanidine (mIBG) has been radiolabelled at the no-carrier-added level with [124I] for a proof of concept study to assess diagnostic accuracy [124I]mIBG PET/CT in detecting metastatic deposits patients diagnosed neuroblastoma. Radiolabelling mIBG was achieved via iododesilylation reaction between [124I]sodium iodide and meta-trimethylsilylbenzylguanidine. produced 62-70 % radioiodide incorporation yield from iodide. The average amount formulated 359 MBq (range 344-389 MBq) an...
Nonpeptidic Arg-Gly-Asp (RGD)-mimic ligands were designed and synthesized by click chemistry between an arginine-azide mimic aspartic acid-alkyne mimic. Some of these molecules combine excellent in vitro properties (high αv β3 affinity, selectivity, drug-like logD, high metabolic stability) with a variety radiolabeling options (e.g., tritium fluorine-18, plus compatibility radio-iodination), not requiring the use chelators or prosthetic groups. The binding mode resulting triazole RGD mimics...
[6‐ O ‐Methyl‐ 11 C]diprenorphine ([ C]diprenorphine) is a positron emission tomography ligand used to probe the endogenous opioid system in vivo . Diprenorphine acts as an antagonist at all of receptor subtypes, that is, μ (mu), κ (kappa) and δ (delta). The radiosynthesis [ using C]methyl iodide produced via ‘wet’ method on home‐built automated set‐up has been described previously. Here, we describe modified synthetic performed gas phase GE TRACERlab FX FE radiochemistry module. Also use...
3578 Background: Survivin, an inhibitor of apoptosis protein, widely overexpressed in cancer is associated with poor clinical outcome. We performed the first worldwide human microdosing imaging PK study ASO LY2181308, a specific, second generation antisense Survivin using carbon-11 radiolabelled LY2181308 ([ 11 C]LY2181308). Methods: was administered at recommended phase II dose (750 mg over 3 hours IV daily x 3, then once weekly). [ C]LY2181308 manufactured to GMP standard by random...
Abstract A major challenge in personalized healthcare is predicting how effective a drug treatment is. This particularly the case oncology, where there call for better therapy monitoring to maximize effectiveness leading improved patient survival and help reduce costs. GE152, nuclear imaging agent under development at GE Healthcare, being evaluated preclinically as tool assess therapeutic efficacy by detecting tumor apoptosis. GE152 based on 99mTechnetium radiolabelled peptide that shows...
Abstract Purpose: The current approach for molecular subtyping of colon cancer relies on gene expression profiling, which is invasive and has limited ability to reveal dynamics spatial heterogeneity. Molecular imaging techniques, such as PET, present a noninvasive alternative visualizing biological information from tumors. However, the factors influencing PET phenotype, suitable radiotracers differentiating tumor subtypes, relationship between phenotypes genotype or expression–based remain...
<p>PET imaging phenotypic difference between primary and metastatic tumors. <b>A,</b> The generation of the <i>Kras<sup>G12D/+</sup> Trp53<sup>fl/fl</sup> Rosa26<sup>N1icd/+</sup></i> (KPN) KPN liver metastasis organoid lines subsequent implantation. One pair lines, generated from a matched mouse tumor metastasis, which were then propagated injected subcutaneously into recipient mice (<i>n</i> = 5)....
<p>PET imaging phenotypic difference between primary and metastatic tumors. <b>A,</b> The generation of the <i>Kras<sup>G12D/+</sup> Trp53<sup>fl/fl</sup> Rosa26<sup>N1icd/+</sup></i> (KPN) KPN liver metastasis organoid lines subsequent implantation. One pair lines, generated from a matched mouse tumor metastasis, which were then propagated injected subcutaneously into recipient mice (<i>n</i> = 5)....