A5016397586- Cancer, Hypoxia, and Metabolism
- Dermatological and Skeletal Disorders
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Cancer-related Molecular Pathways
- Genetic and rare skin diseases.
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- RNA modifications and cancer
- Skin Diseases and Diabetes
- Skin and Cellular Biology Research
- Immune Cell Function and Interaction
- Inflammatory Myopathies and Dermatomyositis
- Tumors and Oncological Cases
- Connective tissue disorders research
- Glutathione Transferases and Polymorphisms
- Dupuytren's Contracture and Treatments
- Systemic Lupus Erythematosus Research
- Pharmacological Receptor Mechanisms and Effects
- Cutaneous Melanoma Detection and Management
- Epigenetics and DNA Methylation
- melanin and skin pigmentation
- Medical Imaging and Pathology Studies
- Autoimmune and Inflammatory Disorders
University of Cambridge
1997-2022
Addenbrooke's Hospital
2004-2020
Clatterbridge Hospital
2020
Cambridge University Hospitals NHS Foundation Trust
2006-2020
ORCID
2020
University of Manchester
2009-2016
CDC Foundation
2015
Cancer Research UK Manchester Institute
2013
Manchester Academic Health Science Centre
2013
Broomfield Hospital
2007
A panel of compounds belonging to the underexposed sulfamate class carbonic anhydrase (CA, EC 4.2.1.1) inhibitors was generated that displayed high specificity at nanomolar levels for tumor-associated CA IX/XII isoforms. Three specific showed a positive response in vitro assays tumor cell migration and spreading. One them, 4-(3′-(3″,5″-dimethylphenyl)ureido)phenyl (S4), taken forward into orthotopic MDA-MB-231 (breast carcinoma) model mice. Treatment with 10 mg/kg maintenance dosage S4 given...
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is upregulated by hypoxia and oncogenic signalling in many solid tumours. Its regulation function thyroid carcinomas are unknown. We evaluated the of HIF-1 target gene expression primary carcinoma cell lines (BcPAP, WRO, FTC-133 8505c). was not detectable normal tissue but expressed carcinomas. Dedifferentiated anaplastic tumours (ATCs) exhibited high levels nuclear staining. The glucose transporter to a similar level all tumour types, whereas...
Prominent early features of COVID-19 include severe, often clinically silent, hypoxia and a pronounced reduction in B cells, the latter important defence against SARS-CoV-2. This presentation resembles phenotype mice with VHL-deficient which Hypoxia-Inducible Factors are constitutively active, suggesting might drive cell abnormalities COVID-19.
Phosphoinositide 3-kinase (PI3K) regulates the transcription factor hypoxia-inducible factor-1 (HIF-1) in thyroid carcinoma cells. Both pathways are associated with aggressive phenotype carcinomas.Our objective was to assess effects of clinical PI3K inhibitor GDC-0941 and genetic inhibition HIF on metastatic behavior cells vitro vivo.Vascular endothelial growth ELISA, activity assays, proliferation studies, scratch-wound migration cell spreading assays were performed under various O(2)...
Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 a transcription factor activated by that regulates the expression of genes promote tumour cell survival, progression, metastasis, resistance to chemo/radiotherapy. In addition hypoxia, HIF-1 can be growth factor-signalling pathways such as mitogen-activated protein kinases- (MAPK-) phosphatidylinositol-3-OH (PI3K-) signalling cascades. Mutations in these are common...
Abstract The hypoxic tumour microenvironment represents an aggressive, therapy-resistant compartment. As arginine is required for specific hypoxia-induced processes, we hypothesised that arginine-deprivation therapy may be useful in targeting cancer cells. We explored the effects of arginine-degrading agent ADI-PEG20 on hypoxia-inducible factor (HIF) activation, nitric oxide (NO) pathway and proliferation using HCT116 UMUC3 cells xenografts. latter lack argininosuccinate synthetase (ASS1)...
Background AEC (ankyloblepharon–ectodermal defects–clefting) syndrome is an autosomal dominant ectodermal dysplasia disorder caused by mutations in the transcription factor p63. Clinically, skin dry and often fragile; other features can include partial eyelid fusion (ankyloblepharon), hypodontia, orofacial clefting, sparse hair or alopecia, nail dystrophy. Objectives To investigate how p63 gene affect protein expression skin. Methods We performed microarray analysis on samples of intact...
We have investigated the biological and therapeutic properties of a humanized anti-CD4 MoAb, hIgG1-CD4, in patients with refractory psoriasis rheumatoid arthritis (RA). hIgG1-CD4 is modulating, non-depleting which induced first-dose reaction most treated. It provided brief symptomatic relief both conditions, appeared easier to control conventional agents after MoAb therapy. At doses used, did not synergize therapeutically panlymphocyte CAMPATH-1H (C1H) RA treated sequentially agents. There...
<h2>Abstract</h2><h3>Background and purpose</h3> Undifferentiated follicular anaplastic thyroid tumours often respond poorly to radiotherapy show increased metastatic potential. We evaluated radiation-induced effects on metastasis in carcinoma cells tumours, mechanistically focusing phosphatidylinositide 3-kinase (PI3K) associated pathways. <h3>Material methods</h3> Migration was analysed (FTC133) (8505c) following (0–6 Gray) with concomitant pharmacological (GDC-0941) or genetic inhibition...
Complement C1q is part of the C1 macromolecular complex that mediates classical complement activation pathway: a major arm innate immune defense. composed A, B, and C chains require post-translational prolyl 4-hydroxylation their N-terminal collagen-like domain to enable formation functional triple helical multimers. The 4-hydroxylase(s) hydroxylate have not previously been identified. Recognized 4-hydroxylases include collagen prolyl-4-hydroxylases (CP4H) more recently described hydroxylase...
We describe a middle‐aged man with aggressive erythrodermic mycosis fungoides whose responses to several well‐established therapies for the disease were either poor or short‐lived. Infusion of antibodies engineered against cells expressing CD4 molecule produced little response. Total body irradiation coupled autologous bone marrow transplantation led an encouraging but unfortunately unsustained improvement.
Journal Article Bullous pemphigoid in infancy developing after the first vaccination Get access J. Hafiji, Hafiji Departments of Dermatology Dr Juber Department Dermatology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UKE‐mail: juber.hafiji@addenbrookes.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar B. Bhogal, Bhogal Immunofluorescence, Guy's and St. Thomas' Hospital NHS Foundation Trust, London, UK E. Rytina, Rytina Histopathology, N. P. Burrows...
Abstract The phosphoinositide 3-kinase (PI3K) pathway is deregulated in a range of cancers, and several targeted inhibitors are entering the clinic. This study aimed to investigate whether positron emission tomography tracer 3′-deoxy-3′-[18F]fluorothymidine ([18F]-FLT) suitable mark effect novel PI3K inhibitor GDC-0941, which has entered phase II clinical trial. CBA nude mice bearing U87 glioma HCT116 colorectal xenografts were imaged at baseline with [18F]-FLT acute (18 hours) chronic (186...
// Rafia S Al-Lamki 1 , Jun Wang Yang Natalie Burrows 2 Patrick H Maxwell Timothy Eisen 3 Anne Y Warren 4 Sakari Vanharanta 5 Simon Pacey Peter Vandenabeele 6 Jordan Pober 7 John R Bradley Department of Medicine, NIHR Cambridge Biomedical Research Centre, University Cambridge, CB2 0QQ, UK School Clinical Institute Medical Research, Campus, 0XY, Oncology, Pathology, Addenbrooke's Hospital, MRC Cancer Unit, Hutchison/MRC 0XZ, VIB Inflammation Center, Ghent University, UGhent-VIB Building FSVM,...
Journal Article Omeprazole‐induced subacute cutaneous lupus erythematosus Get access S. K. Mankia, Mankia Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar E. Rytina, Rytina Pathology, Addenbrooke’s NHS Trust, Cambridge, UK N. P. Burrows Dr Nigel Burrows, Dermatology, Hospital, Cambridge University Hospitals Foundation Hills Road, CB2 OQQ, UKE‐mail: nigel.burrows@addenbrookes.nhs.uk Clinical and Experimental Volume 35, Issue 3, 1 April 2010,...
Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is a rare form of balanitis, with only handful cases reported since the disease was first described. Although condition has been described as benign, there increasing evidence its premalignant potential, several progressing to verrucous or squamous cell carcinoma (SCC). We report case PKMB following penile SCC discuss literature on this condition.
// Natalie Burrows 1, 7 , Joseph Williams 1 Brian A Telfer Julia Resch 2 Helen R Valentine 3 Richard J Fitzmaurice 4 Amanda Eustace Joely Irlam Emily Rowling Cuong Hoang-Vu 5 Catharine M West 3, 6 Georg Brabant Kaye Hypoxia and Therapeutics Group, Manchester Pharmacy School, University of Manchester, UK Experimental Clinical Endocrinology, Medizinische Klinik I, Lubeck, Germany Translational Radiobiology Christie Hospital, NHS Trust, Academic Health Science Centre, Department Histopathology,...
Journal Article Dissecting folliculitis of the scalp with marginal keratitis Get access S. Sivakumaran, Sivakumaran Departments Dermatology and Search for other works by this author on: Oxford Academic Google Scholar P. Meyer, Meyer Ophthalmology, Addenbrooke's NHS Trust, Cambridge, UK N. Burrows Burrows, Department Dermatology, Hills Road, CB2 2QQ, UK. Tel.: +44 1223 216459. Fax: 216863. E‐mail: nigel.burrows@addenbrookes.nhs.uk Clinical Experimental Volume 26, Issue 6, 1 September 2001,...