A5064699259- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Renal Diseases and Glomerulopathies
- Renal cell carcinoma treatment
- Congenital Heart Disease Studies
- Renal and Vascular Pathologies
- Neurotransmitter Receptor Influence on Behavior
- Cell Adhesion Molecules Research
- Dialysis and Renal Disease Management
- Immune Cell Function and Interaction
- Cardiomyopathy and Myosin Studies
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Hematopoietic Stem Cell Transplantation
- Chronic Kidney Disease and Diabetes
- Adrenal and Paraganglionic Tumors
- High Altitude and Hypoxia
- Organ Donation and Transplantation
- Genetic and Kidney Cyst Diseases
- Cancer-related Molecular Pathways
- Tuberous Sclerosis Complex Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Genomics and Rare Diseases
- Liver Disease Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
Churchill Hospital
2017-2022
University of Oxford
2020-2021
Oxford University Hospitals NHS Trust
2018-2021
University of Newcastle Australia
2021
Imperial College London
2015-2016
University College London
2010-2015
Imperial College Healthcare NHS Trust
2015
Whittington Hospital
2015
Hammersmith Hospital
2013
University of Florida
1980-2010
Inactivation of p53-dependent apoptosis promotes oncogenic transformation, tumor development, and resistance to many cytotoxic anticancer agents. p53 can transcriptionally activate bax , a bcl-2 family member that apoptosis. To determine whether is required for apoptosis, the effects deficiency were examined in primary fibroblasts expressing E1A oncogene, setting where dependent on endogenous p53. We demonstrate function as an effector chemotherapy-induced contributes pathway suppress...
Pavlovian conditioned cues exert a powerful influence on instrumental actions directed towards common reward, this is known as Pavlovian-to-instrumental transfer (PIT). The nucleus accumbens (NAcc) has been hypothesized to function an interface between limbic cortical structures required for associative conditioning, like the amygdala, and response mechanisms through which behaviour can be selected performed. Here we have used selective excitotoxic lesions investigate involvement of...
Recent studies suggest that the metabolic syndrome is associated with renal disease. We previously reported a high-fructose diet, but not high-glucose can induce and accelerate chronic disease in rats. now examined effects of diet on normal rat kidneys. Three groups Sprague-Dawley rats were pair fed special containing 60% fructose, glucose, or control standard chow for 6 wk, then histological performed. The effect fructose to cell proliferation cultured proximal tubular cells was also...
Tubulointerstitial kidney disease is an important cause of progressive renal failure whose aetiology incompletely understood. We analysed a large pedigree with maternally inherited tubulointerstitial and identified homoplasmic substitution in the control region mitochondrial genome (m.547A>T). While mutations mtDNA coding sequence are well recognised affecting multiple organs, have never been shown to disease. Strikingly, our patients did not classical features Patient fibroblasts showed...
Autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by mutations in the UMOD gene (ADTKD-UMOD) is considered rare and often remains unrecognised. We aimed to establish prevalence of genetic diseases, ADTKD ADTKD-UMOD adult chronic (CKD) patients, investigate characteristic features. sent questionnaires on family history all patients with CKD stages 3–5 our tertiary renal centre identify inherited disease. Details clinical were obtained from patient interviews records. Sanger...
Recently, we and others reported that diabetic endothelial nitric oxide synthase knockout (eNOSKO) mice develop advanced glomerular lesions include mesangiolysis nodular lesions. Interestingly, insulin treatment lowered blood pressure prevented renal lesions, raising the question as to whether these beneficial effects of were due its ability lower either high glucose levels or pressure. We, therefore, examined effect lowering using hydralazine in this eNOSKO mouse model. Hydralazine...
Alport syndrome (AS) is a familial glomerular disorder resulting from mutations in the genes encoding several members of type IV collagen protein family. Despite advances molecular genetics, renal biopsy remains an important initial diagnostic tool. Histological diagnosis challenging as features may be non-specific, particularly early disease course and females with X-linked disease. We present three families for whom there was difficulty correctly diagnosing AS or thin basement membrane...
Hereditary microscopic haematuria often segregates with mutations of COL4A3, COL4A4 or COL4A5 but in half families a gene is not identified. We investigated Cypriot family autosomal dominant renal failure and kidney cysts.We used genome-wide linkage analysis, whole exome sequencing cosegregation analyses.We identified novel frameshift mutation, c.4611_4612insG:p.T1537fs, exon 49 COL4A1. This mutation predicts truncation the protein disruption C-terminal part NC1 domain. confirmed its...
Background: Immunoglobulin M (IgM) nephropathy is an idiopathic glomerulonephritis characterized by diffuse mesangial deposition of IgM. IgM has been a controversial diagnosis since it was first reported, and there are few data identifying specific pathological features that predict the risk progression renal disease. Methods: We identified 57 cases among 3220 adults undergoing biopsy at our institution. Biopsies had to satisfy following three criteria meet definition in this study: (i)...
Background This is the first report of incidence and causes end-stage renal disease (ESRD) Turkish-Cypriot population in Northern Cyprus. Methods Data were collected over eight consecutive years (2004–2011) from all those starting replacement therapy (RRT) this population. Crude age-standardised at 90 days was calculated comparisons made with other national registries. We DNA entire prevalent As an initial experiment we looked for two genetic ESRD that have been reported Greek Cypriots....
Postexercise arm-to-leg blood pressure gradients were measured in 31 patients to determine the effectiveness of two surgical techniques for treating coarctation aorta. The postexercise mean systolic gradient was 29 mm Hg lower 13 treated with Dacron patch angioplasty than 18 whose resected (p less 0.01). Some high after resection had a reduced proximal aortic lumen by angiography. results this study indicate that is method choice effectively reducing and hypoplasia isthmus.
Letrozole, an aromatase inhibitor, is a commonly used neo-adjuvant drug to treat hormone-sensitive breast cancer. There have been few cases of inhibitor induced vasculitis but the first case letrozole-induced was reported from Switzerland in 2014 (Digklia et al.) [1].We report 72-year-old woman with small She started on pre-operative letrozole (2.5mg/d) whilst awaiting surgery. Ten days later she presented burning pain and purpuric skin lesions which progressed extensive ischaemic...
The ability to identify regions of the genome inherited with a dominant trait in one or more families has become increasingly valuable wide availability high throughput sequencing technology. While number methods exist for mapping homozygous variants segregating recessive traits consanguineous families, conditions are conventionally analysed by linkage analysis, which requires computationally demanding haplotype reconstruction from marker genotypes and, even using advanced parallel...
Radiation nephropathy is a rare complication following total body irradiation (TBI) and peptide receptor radionuclide therapy (PRRT). Yttrium 90-DOTATOC (Y90) somatostatin analogue labelled with Y90 used for somatostatin-positive neuroendocrine tumours. renally excreted has cumulative effect in the renal parenchyma Despite fractionation co-administration of renoprotective intravenous amino acids, targeted can still be nephrotoxic. Rising adoption PRRT led to re-emergence radiation...
You have accessJournal of Urology1 Apr 2008OPERATING ROOM COST ANALYSIS: A SURVEY OF AWARENESS AMONG UROLOGIC SURGERY STAFF Ted Skolarus, Robert L Grubb, Thomas M Connor, Gerald Andriole, and Sam B Bhayani SkolarusTed Skolarus More articles by this author , GrubbRobert Grubb ConnorThomas Connor AndrioleGerald Andriole BhayaniSam View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60167-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...